A series of seventeen novel 1,2,3-Triazole derivatives were efficiently synthesized in excellent yields by the popular ‘click chemistry’ approach and evaluated for their in vitro anti-tubercular activity against Mycobacterium ...
Maurya, C K; Singh, Rohit; Jaiswal, Natasha; Venkateswarlu, K; Narender, Tadigoppula; Tamrakar, A K(2014)
The 4‐Hydroxyisoleucine (4‐HIL), an unusual amino acid isolated from the seeds of Trigonella foenum‐graecum was investigated for the metabolic effects to ameliorate free fatty acid‐induced insulin resistance in skeletal ...
There are many chemotherapeutic interventions available for tuberculosis (TB) and are in use for more than five decades, but still there is an urgent need for novel drugs against new targets due to emergence of resistant ...
A highly sensitive and selective LC-MS/MS assay was developed and validated for determination of a novel antitubercular compound S006-830 in rat plasma. The analyte and internal standard (IS) were extracted from plasma by ...
Rohitukine (RH) is a chromone alkaloid considered as one of the major active components of Dysoxylum binectariferum, exhibiting diverse pharmacological activities such as anti-hyperlipidmic, anti-cancer, anti-inflammatory, ...
Enantiomerically enriched indolines and tetrahydroisoquinolines were synthesized within 5 min to 2 h in high yields from easily accessible (S)-amino acids derived chiral carbocations. The diastereoselective Friedel-Crafts ...
Steroids have long played a vital role in the organic synthesis because of their unique structural design and associated biological properties. In recent years, asymmetric synthesis has emerged as a powerful tool for ...
Natural products have been used traditionally for the treatment and prevention of diseases. Diapocynin is the analogue of the naturally occurring apocynin, a well-known constituent of the Picrorhiza kurroa. It has antioxidant ...
Tamrakar, Akhilesh K; Maurya, Chandan K.; Rai, Amit K(2014)
Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the negative regulation of insulin signal transduction pathway and has emerged as novel therapeutic strategy for the treatments of type 2 ...
Pramanik, M M D; Chaturvedi, A K; Rastogi, Namrata(2014)
We report a substituent controlled nucleophilic displacement of alkyl bromides with Bestmann-Ohira reagent yielding either dimethyl diazoalkylphosphonates or (E)-vinylphosphonates. The dimethyl diazoalkylphosphonates could ...
Jaiswal, A K; Khare, Prashant; Joshi, Sumit; Kushawaha, P K; Sundar, Shyam; Dube, Anuradha(2014)
In visceral leishmaniasis, the recovery from the disease is always associated with the generation of Th1-type of cellular responses. Based on this, we have previously identified several Th1-stimulatory proteins of Leishmania ...
Focused libraries of Trisubstituted methanes (TRSMs) have been synthesized through Grignard reaction of aryl magnesium bromide with various carbaldehydes followed by Friedel-Crafts alkylation of diaryl carbinols with ...
The palladium-catalysed isocyanide insertion in 2-bromophenylthioureas results into the formation of 4-substitutedimino-4H-benzo[d][1,3]thiazin-2-amines via C-S cross coupling reaction of the intermediate imidoylpalladium ...
Formal acylamination of aromatic nitroalkenes with 2-aminobenzoyl benzotriazoles in aqueous methanol results into diastereoselective synthesis of 2-aryl-3-nitro-2,3-dihydro-quinolin-4(1H)-ones. The aliphatic nitroalkenes ...
Sashidhara, K V; Singh, S P; Varshney, Salil; Beg, Muheeb; Gaikwad, A N(2014)
In our efforts to develop safe and active chemical entities from nature, we first identified poliothrysoside (1), a phytoconstituent isolated from Flacourtia indica, possessing antidiabetic potential. Subsequently, fifteen ...
Singh, Yuvraj; Ojha, Preeti; Srivastava, Mukesh; Chourasia, M K(2015)
This work demonstrates Box Benhken design (BBD)’s capability in exploring scientific principles governing a process, different from its use in process optimization. We have investigated nanoprecipitation (NP) of temozolomide ...
Kumar, Vikash; Krishna, Shagun; Siddiqi, M I(2015)
Virtual screening (VS) is a well-established technique, which is now routinely employed in computer aided drug designing process. VS can be broadly classified into two categories, i.e., ligand-based and structure-based ...
According to World Health Organization obesity is defined as an excessive accumulation of fat, which increases risk of other metabolic disorders such as insulin resistance, dyslipidemia, hypertension, cardiovascular diseases, ...
Prakash, Kirtika; Goyal, Manish; Soni, Awakash; Siddiqui, A J; Bhardwaj, Jyoti; Puri, S K(2014)
Plasmodium parasite utilizes superoxide dismutase family proteins to limit the toxicity of reactive oxygen species, such as produced through hemoglobin degradation. These proteins play an important role in parasite survival ...