• Antioxidant And Haematoprotective Activity of The Saraca Indica Stem Bark 

  Dubey, C K; Meena, A K; Mishra, Vaibhav; Singh, Poonam; Bansode, F W; Singh, R K (2015)

  Present study was designed to evaluate the antioxidant and hematoprotective activity of methanolic extract of saraca indica bark. Antioxidants and hematoprotective effect of saraca indica bark may be due to its polyphenolic ...
• microRNAs: role in leukemia and their computational perspective 

  Omer, Ankur; Singh, Poonam; Yadav, N K; Singh, R K (2015)

  MicroRNAs belong to the family of ncRNAs and had gained importance due to its role in complex biochemical pathways. Changes in the expression of protein coding genes are the major cause of leukemia. Role of miRNAs as tumor ...
• Curcumin Affords Protection against Valproic Acid Induced Teratogenicity by Curtailing Oxidative Stress and Inhibiting CYP2C9 activity 

  Kumar, Akhilesh; Chandasana, Hardik; Bhatta, R S; Sethi, Nikunj; Yadav, Sudhaker; Sinha, Neeraj (2015)

  Administration of drugs during pregnancy is always done with immense caution however, multiple neurological ailments including epilepsy and depression warrant medical treatments even during pregnancy. This exposes unborn ...
• Ida-1, the Caenorhabditis elegans Orthologue of Mammalian Diabetes Autoantigen IA-2, Potentially Acts as a Common Modulator between Parkinson’s Disease and Diabetes: Role of Daf-2/Daf-16 Insulin Like Signalling Pathway 

  Fatima, Soobiya; Haque, Rizwanul; Jadiya, Pooja; Shamsuzzama; Kumar, Lalit; Nazir, Aamir (2014)

  The lack of cure to age associated Parkinson’s disease (PD) has been challenging the efforts of researchers as well as health care providers. Recent evidences suggest that diabetic patients tend to show a higher future ...
• Molecular insights of protein contours recognition with ligand pharmacophoric sites through combinatorial library design and MD simulation in validating HTLV-1 PR inhibitors 

  Selvaraj, Chandrabose; Omer, Ankur; Singh, Poonam; Singh, S K (2015)

  In Retroviruses HIV-1 and HTLV-1 are most dangerous pathogens, which cause much damage to the Homo sapiens. Both viruses are having protease enzyme which common for its replication mechanism besides its structural unique ...
• Insulin-degrading enzyme: A link between Alzheimer’s and type 2 diabetes mellitus 

  Haque, Rizwanul; Nazir, Aamir (2014)

  Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, ...
• Ameliorative Effect of Hibiscus rosa sinensis on Phenylhydrazine Induced Haematotoxicity 

  Meena, A K; Patidar, Devendra; Singh, R K (2014)

  This research work was focused on the haemoprotective activity of methanolic extract of Hibiscus rosa sinensis L. (HRS) flowers against phenylhydrazine induced haematotoxicity in Charles foster rats. Haemoprotective activity ...
• An Overview of Data Mining Algorithms in Drug Induced Toxicity Prediction 

  Omer, Ankur; Singh, Poonam; Yadav, N K; Singh, R K (2014)

  The increase in chemical diversity has increased the need to adjudicate the toxicity of different chemical compounds raising the burden on the demand of animal testing. The toxicity evaluation requires, time consuming and ...
• Macrophages are Recruited to Hypoxic Tumor Areas and Acquire a Pro-Angiogenic M2-Polarized Phenotype via Hypoxic Cancer Cell Derived Cytokines Oncostatin M and Eotaxin 

  Tripathi, Chakrapani; Tewari, B N; Kanchan, R K; Baghel, K S; Nautiyal, Naveen; Shrivastava, Richa; Kaur, Harbeer; Bhatt, M L B; Bhadauria, Smrati (2014)

  TAMs, a unique and distinct M2-skewed myeloid population of tumor stroma, exhibiting pro-tumor functions is fast emerging as a potential target for anti-cancer immunotherapy. Macrophage-recruitment and M2-polarization ...
• The metabolic enhancer piracetam attenuates the mitochondrion-specific endonuclease-G translocation and oxidative DNA fragmentation 

  Gupta, Sonam; Verma, D K; Biswas, Joyshree; Raju, K S R; Joshi, Neeraj; Wahazuddin; Singh, Sarika (2014)

  The present study was performed to investigate the involvement of mitochondrion – specific endonuclease G in piracetam (P) induced protective mechanisms. Studies have showed the antiapoptotic effect of piracetam but still ...
• Some Indian Traditional Medicinal Plants with Antioxidant Activity: A Review 

  Katiyar, Shikhar; Patidar, Devendra; Gupta, Shailja; Singh, R K; Singh, Poonam (2013)

  Since the beginning of human civilization, a number of Indian medicinal plants have been used in the traditional system of medicine (Ayurveda), aiming to maintain health and to cure diseases. Oxidative stress has emerged ...
• Okadaic acid induced Tau phosphorylation in rat brain: Role of NMDA receptor 

  Kamat, P K; Rai, Shivika; Swarnkar, Supriya; Shukla, Rakesh; Ali, Shakir; Najmi, A K; Nath, Chandishwar (2013)

  Okadaic acid (OKA) is potent inhibitor of protein phosphatases 1/2A (PP2A). Inhibition of PP2A leads to hyperphosphorylation of Tau protein. Hyperphosphorylated Tau protein is present in intraneuronal neurofibrillary tangles ...
• Rotenone induced neurotoxicity in rat brain areas: A study on neuronal and neuronal supportive cells 

  Swarnkar, Supriya; Goswami, Poonam; Kamat, P K; Patro, I K; Singh, Sarika; Nath, Chandishwar (2013)

  The present study was conducted to correlate rotenone-induced neurotoxicity with cellular and molecular modifications in neuronal and neuronal supportive cell in rat brain regions. Rotenone was administered (3, 6 and ...
• Dynamics of Physical Interaction between HIV-1 Nef and ASK1: Identifying the Interacting Motif(S) 

  Kumar, Balawant; Tripathi, Chakrapani; Kanchan, R K; Tripathi, J K; Ghosh, J K; Ramachandran, Ravishankar; Bhadauria, Smrati; Tripathi, R K (2013)

  FasL mediated preferential apoptosis of bystander CTLs while protection of infected CD4+T cells remains one of the hallmarks of immune evasion during HIV infection. The property of infected host cells to evade cell-autonomous ...
• Human Beta Casein Fragment (54–59) Modulates M. bovis BCG Survival and Basic Transcription Factor 3 (BTF3) Expression in THP-1 Cell Line 

  Thakur, Dharamsheela; Saxena, Reshu; Singh, Vandana; Haq, Wahajul; Katti, S B; Singh, B N; Tripathi, R K (2012)

  Immunostimulatory peptides potentiate the immune system of the host and are being used as a viable adjunct to established therapeutic modalities in treatment of cancer and microbial infections. Several peptides derived ...
• Trans-Cellular Introduction of HIV-1 Protein Nef Induces Pathogenic Response in Caenorhabditis elegans 

  Nazir, Aamir; Sammi, S R; Singh, Pankaj; Tripathi, R K (2010)

  Background: Caenorhabditis elegans has emerged as a very powerful model for studying the host pathogen interactions.Despite the absence of a naturally occurring viral infection for C. elegans, the model is now being exploited ...
• Acute Exposure of Apigenin Induces Hepatotoxicity in Swiss Mice 

  Singh, Prabhat; Mishra, S K; Noel, Sanjeev; Sharma, Sharad; Rath, Srikanta Kumar (2012)

  Apigenin, a dietary flavonoid, is reported to have several therapeutic effects in different diseases including cancer. Toxicity of Apigenin is however, least explored, and reports are scanty in literature. This warrants ...
• HIV-1 Nef Breaches Placental Barrier in Rat Model 

  Singh, Poonam; Agnihotri, S K; Tewari, M C; Kumar, Sadan; Sachdev, Monika; Tripathi, R K (2012)

  The vertical transmission of HIV-1 from the mother to fetus is known, but the molecular mechanism regulating this transmission is not fully characterized. The fetus is highly protected by the placenta, which does not permit ...
• A study on neuroinflammatory marker in brain areas of Okadaic acid (ICV) induced memory impaired rats 

  Kamat, P K; Tota, S K; Rai, Shivika; Swarnkar, Supriya; Shukla, Rakesh; Nath, Chandishwar (2012)

  Aims: The aim of the present study is to investigate the status of proinflammatory cytokine in the brain of intracerebroventricular (ICV) okadaic acid (OKA) induced memory impaired rat. Main methods: OKA (200ng) ...
• Chloramphenicol Toxicity: A Review 

  Shukla, Pooja; Bansode, F W; Singh, R K (2011)

  Chloramphenicol (CAP) is a potent and efficient antibiotic used since years against many pathogens. Despite being highly effective, it shows severe toxicity in the form of Aplastic anemia (AA) and bone marrow suppression. ...

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