• Synthesis and Biological Evaluation of Novel 1,2,3-Triazole derivatives as Anti-TB Agents 

  Ali, Abdul A.; Gogoi, Dhrubajyoti; Buragohain, Alak K.; Saikia, Prakash J.; Gehlot, Praveen S; Kumar, Arvind; Trivedi, Priyanka; Chaturvedi, Vinita; Sarma, Diganta (CSIR-CDRI, 2016)

  A series of seventeen novel 1,2,3-Triazole derivatives were efficiently synthesized in excellent yields by the popular ‘click chemistry’ approach and evaluated for their in vitro anti-tubercular activity against Mycobacterium ...
• 4‐Hydroxyisoleucine ameliorates fatty acid‐induced insulin resistance and inflammatory response in skeletal muscle cells 

  Maurya, C K; Singh, Rohit; Jaiswal, Natasha; Venkateswarlu, K; Narender, Tadigoppula; Tamrakar, A K (2014)

  The 4‐Hydroxyisoleucine (4‐HIL), an unusual amino acid isolated from the seeds of Trigonella foenum‐graecum was investigated for the metabolic effects to ameliorate free fatty acid‐induced insulin resistance in skeletal ...
• PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011-2014) 

  Tamrakar, Akhilesh K; Maurya, Chandan K.; Rai, Amit K (2014)

  Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the negative regulation of insulin signal transduction pathway and has emerged as novel therapeutic strategy for the treatments of type 2 ...
• Synthesis of Nanoparticles Using Euphorbia prostrata Extract Reveals a Shift from Apoptosis to G0/G1 Arrest in Leishmania donovani 

  Zahir, Abdul Abduz; Chauhan, Indira Singh; Bagavan, Asokan; Kamaraj, Chinnaperumal; Elango, Gandhi; Shankar, Jai; Arjaria, Nidhi; Roopan, Mohana; Rahuman, Abdul Abdul; Singh, Neeloo (2014)

  The aim of the present investigation was to synthesize silver (Ag) and titanium dioxide (TiO2) nanoparticles (NPs) using the aqueous leaves extract of Euphorbia prostrata as antileishmanial agents and to explore the mechanism ...
• Melatonin Reverses Fas, E2F-1 and Endoplasmic Reticulum Stress Mediated Apoptosis and Dysregulation of Autophagy Induced by the Herbicide Atrazine in Murine Splenocytes 

  Sharma, Shweta; Sarkar, Jayanta; Haldar, Chandana; Sinha, Sudhir (2014)

  Exposure to the herbicide Atrazine (ATR) can cause immunotoxicity, apart from other adverse consequences for animal and human health. We aimed at elucidating the apoptotic mechanisms involved in immunotoxicity of ATR and ...
• Nymphaea rubra ameliorates TNF-α-induced insulin resistance via suppression of c-Jun NH2-Terminal Kinase and Nuclear Factor-κB in the rat skeletal muscle cells 

  Gautam, Sudeep; Rahuja, Neha; Ishrat, Nayab; Asthana, R K; Mishra, D K; Maurya, Rakesh; Jain, S K; Srivastava, A K (2014)

  In this work, we demonstrated insulin signaling and the anti-inflammatory effects by the chloroform fraction of ethanolic extract of Nymphaea rubra flowers in TNF-α induced insulin resistance in the rat skeletal muscle ...
• 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells 

  Maurya, C K; Singh, Rohit; Jaiswal, Natasha; Venkateswarlu, K; Narender, Tadigoppula; Tamrakar, A K (2014)

  The 4-Hydroxyisoleucine (4-HIL), an unusual amino acid isolated from the seeds of Trigonella foenum-graecum was investigated for the metabolic effects to ameliorate free fatty acid-induced insulin resistance in skeletal ...
• Antidiabetic and Antidyslipidemic Activity of Ethyl Acetate Fractions Xylocarpus Granatum and Xylocarpus Molluccensis on High Fructose High Fat and High Sucrose High Fat Fed-Low Dosed Streptozotocin Treated Diabetic Rats 

  Srivastava, S P; Mishra, Akansha; Lakshmi, Vijai; Tamrakar, A K; Srivastava, M N; Srivastava, A K (2015)

  Objectives: The present study was carried out to investigate the antidiabetic and antidyslipidemic effect of standardized fractions of X. granatum (CDR-134 F194) and X. molluccensis (CDR-267F018) by measuring the status ...
• 4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway 

  Rawat, A K; Korthikunta, Venkateswarlu; Gautam, Sudeep; Pal, Savita; Tadigoppula, Narender; Tamrakar, A K; Srivastava, A K (2014)

  4-Hydroxyisoleucine (4-HIL) is an unusual amino acid isolated from Fenugreek seeds (Trigonella foenum graecum L). Various studies have shown that it acts as an antidiabetic agent yet its mechanism of action is not clear. ...
• Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells 

  Jaiswal, Natasha; Gunaganti, Naresh; Maurya, C K; Narender, Tadigoppula; Tamrakar, A K (2015)

  Elevated fatty acid levels play pathogenic role in the development of insulin resistance, associated with type 2 diabetes. Interventions with ability to ameliorate fatty acid-induced insulin resistance might be useful for ...
• Orally active osteoanabolic agent 6-C-β-D-glucopyranosyl-(2S, 3S)-(+)- 5,7, 3',4'- tetrahydroxydihydroflavonol binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling and improves metabolic health in a rodent model of diabetes 

  Singh, A K; Joharapurkar, A A; Khan, M P; Mishra, J S; Singh, Nidhi; Yadav, Manisha; Hossain, Zakir; Khan, Kainat; Kumar, Sudhir; Dhanesha, N A; Mishra, D P; Maurya, Rakesh; Sharma, Sharad; Jain, M R; Trivedi, A K; Godbole, M M; Gayen, J R; Chattopadhyay, Naibedya; Sanyal, Sabyasachi (2014)

  Adiponectin is an adipocytokine that signals through plasma membrane-bound adiponectin receptors (AdipoR) -1 and -2. Plasma adiponectin depletion is associated with type 2 diabetes, obesity and cardiovascular diseases. ...
• Purification and Characterization of Guanylate kinase, a nucleoside monophosphate kinase of Brugia malayi 

  Gupta, Smita; Yadav, Sunita; Singh, Nidhi; Verma, Anita; Siddiqui, Imran; Saxena, J K (2014)

  Guanylate kinase, a nucleoside monophosphate kinase of Brugia malayi which is involved in reversible transfer of phosphate group from ATP to GMP, was cloned, expressed and characterized. The native molecular mass of BmGK ...
• Molecular cloning and characterization of Brugia malayi thymidylate kinase 

  Doharey, P K; Sutha, M K; Verma, Anita; Kumar, Vikash; Yadav, Sunita; Balaramnavar, V M; Rathaur, Sushma; Saxena, A K; Siddiqi, M I; Saxena, J K (2014)

  Thymidylate kinase (TMK) is a potential chemotherapeutic target because it is directly involved in the synthesis of deoxythymidine triphosphate, which is an essential component for DNA synthesis. The gene encoding thymidylate ...
• Antidiabetic and Hypolipidemic Activity in Stem of Jatropha Gossypifolia L. 

  Rahuja, Neha; Mishra, Akansha; Maurya, Rakesh; Srivastava, M N; Tamrakar, A K; Jain, S K; Srivastava, A K (2013)

  Objectives- The present study carried out to investigate the antidiabetic and hypolipidemic efficacy of active fractions (chloroform fraction of 95% ethanolic extract and butanol fraction of aqueous extract) of ...
• Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance 

  Ashutosh; Garg, Garg; Sundar, Shyam; Duncan, Robert; Nakhasi, H L; Goyal, Neena (2012)

  Emergence of resistance to pentavalent antimonials has become a severe obstacle in treatment of visceral leishmaniasis (VL) in the Indian subcontinent. The mechanisms operating in laboratory generated strains are somewhat ...
• Lipid lowering and antioxidant effect of miglitol in triton treated hyperlipidemic and high fat diet induced obese rats 

  Shrivastava, Atul; Chaturvedi, Upma; Singh, S V; Saxena, J K; Bhatia, Gitika (2013)

  Miglitol an anti-diabetic drug has been shown to reduce plasma lipids and inhibit free radical generation. The anti-hyperlipidemic and antioxidant effect of miglitol were studied in triton induced hyperlipidemic rats and ...
• Molecular Cloning and Characterization of Glucose-6-phosphate dehydrogenase from Brugia malayi 

  Verma, Anita; Suthar, M K; Doharey, P K; Gupta, Smita; Yadav, Sunita; Chauhan, P M S; Saxena, J K (2013)

  Glucose 6-phosphate dehydrogenase (G6PD) a regulatory enzyme of pentose phosphate pathway from Brugia malayi was cloned, expressed and biochemically characterised. The Km values for glucose 6-phosphate and NADP were 0.25 ...
• Diastereomeric mixture of calophyllic acid and isocalophyllic acid stimulates glucose uptake in skeletal muscle cells: Involvement of PI-3-Kinase- and ERK1/2-dependent pathways 

  Prasad, Janaki; Maurya, C K; Pandey, Jyotsana; Jaiswal, Natasha; Madhur, Gaurav; Srivastava, A K; Narender, Tadigoppula; Tamrakar, A K (2013)

  The diastereomeric mixture of calophyllic acid and isocalophyllic acid (F015) isolated from the leaves of Calophyllum inophyllum was investigated for the metabolic effect on glucose transport in skeletal muscle cells. In ...
• Confirmation towards establishing antidiabetic activity in heart wood of Pterocarpus marsupium and analysis of phytoconstituents 

  Mishra, Akansha; Srivastava, Rohit; Srivastava, S P; Gautam, Sudeep; Maurya, Rakesh; Tamrakar, A K; Srivastava, A K (2013)

  The crude powder, ethanolic extract and aqueous, chloroform, hexane and n-butanol soluble fractions of ethanolic extract of heart wood of Pterocarpus marsupium (Family: Fabaceae) showed marked improvement on oral glucose ...
• Cloning, characterization and sub-cellular localization of gamma subunit of T-complex protein1 (chaperonin) from Leishmania donovani 

  Bhaskar; Kumari, Neeti; Goyal, Neena (2012)

  T-complex protein-1 (TCP1) complex, a chaperonin class of protein, ubiquitous in all genera of life, is involved in intracellular assembly and folding of various proteins. The gamma subunit of TCP1 complex (TCP1γ), plays ...

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