• Reinvestigating nanoprecipitationvia Box Benhken Design: A systematic approach 

  Singh, Yuvraj; Ojha, Preeti; Srivastava, Mukesh; Chourasia, M K (2015)

  This work demonstrates Box Benhken design (BBD)’s capability in exploring scientific principles governing a process, different from its use in process optimization. We have investigated nanoprecipitation (NP) of temozolomide ...
• Development, characterization and toxicological evaluations of phospholipids complexes of curcumin for effective drug delivery in cancer chemotherapy 

  Khatik, Renuka; Dwivedi, Pankaj; Shukla, Ankita; Srivastava, Pallavi; Rath, S K; Paliwal, S K; Dwivedi, A K (2016)

  The purpose of present study was to prepare and characterize the complexes between curcumin (CU) phosphatidlycholine (PC) and hydrogenated soya phosphatidlycholine (HSPC) and to evaluate their anticancer activity. These ...
• Assay method for quality control and stability studies of a new antithrombotic agent (S007-867) 

  Khandelwal, Kiran; Pachauri, S D; Singh, S; Pandey, R R; Ahmed, Hafsa; Dwivedi, Pankaj; Arya, Abhishek; Kumar, A; Dikshit, D K; Dwivedi, A K (2014)

  A substituted 5-(piperidine-1-carbonyl)pyrrolidin-2-one (CDRI compound S007-867) is a potent antithrombotic candidate drug under development at our Institute. An HPLC method for determination of S007-867 with its intermediates ...
• Stability Indicating Studies on NMITLI 118R (Standardized Extract Of Withania somnifera Dunal.) 

  Ahmad, Hafsa; Khandelwal, Kiran; Pachauri, S D; Sanghwan, R S; Dwivedi, A K (2014)

  Background: Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant of great medicinal value; used in many clinically proven conditions. NMITLI-118R a candidate drug under a CSIR networking project is a chemotype ...
• Perspectives of nanoemulsion assisted oral delivery of docetaxel for improved chemotherapy of cancer 

  Verma, Prerna; Meher, J G; Asthana, Shalini; Pawar, V K; Chaurasia, Mohini; Chourasia, M K (2016)

  Context: Nanoemulsions (NE) are one of the robust delivery tools for drugs due to their higher stability and efficacy. Objectives: The purpose of present investigation is to develop stable, effective and safe NE of ...
• Therapeutic Intervention of Sepsis: Current and Anticipated Pharmacological Agents 

  Shukla, Prashant; Rao, G M; Pandey, Gitu; Sharma, Shweta; Mittapelly, Naresh; Shegokar, Ranjita; Mishra, P R (2014)

  Sepsis is a clinical syndrome characterized by a multisystem response to a pathogenic assault due to underlying infection involves conglomerate of interconnected biochemical, cellular, and organ-organ interaction networks. ...
• Chitosan Assisted Immunotherapy for Intervention of Experimental Leishmaniasis via Amphotericin B Loaded Solid Lipid Nanoparticles 

  Jain, Vineet; Gupta, Annie; Pawar, V K; Asthana, Shalini; Jaiswal, A K; Dube, Anuradha; Chourasia, M K (2014)

  Solid lipid nanoparticles (SLNs) have emerged as an excellent substitute over polymeric nanoparticles and when incorporated with chitosan which activates the macrophage to impart an immune response, produces excellent ...
• HPLC analytical method for simultaneous estimation of Mefloquine and Clarithromycin 

  Ahmad, Hafsa; Khandelwal, Kiran; Pachauri, S D; Gunjan, Sarika; Tripathi, Renu; Dwivedi, A K (2014)

  Abstract Clarithromycin is a semi-synthetic macrolide anti-biotic exhibiting good antimicrobial activity over erythromycin and mefloquine is an anti-malarial agent against falciparum malaria. Clarithromycin, a cytochrome ...
• Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice 

  Dwivedi, Pankaj; Khatik, Renuka; Khandelwal, Kiran; Srivastava, Richa; Taneja, Isha; Raju, K S R; Dwivedi, Hemlata; Shukla, Prashant; Gupta, Pramod; Singh, Sarika; Tripathi, Renu; Paliwal, S K; Wahajuddin; Dwivedi, A K; Mishra, P R (2014)

  Objective: The aim of the study was to develop oral arteether (AE) nano formulations and to investigate its effects in rats; for complete and effective treatment of Plasmodium yoelii nigeriensis infected mice at reduced ...
• Targeting of Gastrointestinal Tract for Amended Delivery of Proteins/Peptides Therapeutics: Strategies and Industrial Perspectives 

  Pawar, V K; Meher, J G; Singh, Yuvraj; Chaurasia, Mohini; Reddy, B S; Chourasia, M K (2014)

  Delivery of proteins/peptides in gastrointestinal (GI) tract via peroral/oral route involves tremendous challenges due to unfavorable environmental conditions like harsh pH, presence of proteolytic enzymes and absorption ...
• Immunotherapeutic Vitamin E Nanoemulsion Synergies the Antiproliferative Activity of Paclitaxel in Breast Cancer Cells via Modulating Th1 and Th2 Immune Response 

  Pawar, V K; Panchal, S B; Singh, Yuvraj; Meher, J G; Sharma, Komal; Singh, Pankaj; Bora, H K; Singh, Akhilesh; Datta, Dipak; Chourasia, M K (2014)

  Paclitaxel (PTX) is used as first line treatment for metastatic breast cancer but the relief comes at a heavy cost in terms of accompanying adverse effects. The pharmaceutical credentials of PTX are further dampened by the ...
• Moxifloxacin Loaded Nanoemulsions having Tocopheryl Succinate as Integral Component Improves Pharmacokinetics and Enhances Survival in E Coli Induced Complicated Intra-Abdominal Infection 

  Shukla, Prashant; Verma, A K; Dwivedi, Pankaj; Yadav, Arti; Gupta, P K; Rath, S K; Mishra, P R (2014)

  In the present work a novel nanoemulsion laden with moxifloxacin has been developed for effective management ofcomplicated Intra-abdominal infections.Moxifloxacin nanoemulsion fabricated using high pressure homogenization ...
• Design, synthesis and molecular docking of substituted 3-hydrazinyl-3-oxo-propanamides as anti-tubercular agents 

  Naqvi, Arshi; Malasoni, Richa; Srivastava, Akansha; Pandey, R R; Dwivedi, A K (2014)

  Based on the anti-mycobacterial activity of various acid hydrazides, a series of substituted 3-hydrazinyl-3-oxo-propanamides has been designed. The target compounds have been synthesized from diethylmalonate using substituted ...
• Arteether nanoemulsion for enhanced efficacy against Plasmodium yoelii nigeriensis malaria: An approach by enhanced bioavailability 

  Dwivedi, Pankaj; Khatik, Renuka; Chaturvedi, Priyanka; Khandelwal, Kiran; Taneja, Isha; Raju, K S R; Dwivedi, Hemlata; Singh, S K; Gupta, P K; Shukla, Prashant; Tripathi, Priyanka; Singh, Sarika; Tripathi, Renu; Wahajuddin; Paliwal, S K; Dwivedi, A K; Mishra, P R (2015)

  The present work is focused on the preparation of nanoemulsions (NEs) loaded with arteether (ART) for its enhanced efficacy against malaria parasites. ART-NEs have been prepared using high pressure homogenization (HPH) ...
• Potential in vitro and in vivo colon specific anticancer activity on HCT- 116 Xenograft Nude mice model: Targeted delivery using enteric coated folate modify nanoparticles 

  Khatik, Renuka; Dwivedi, Pankaj; Reddy, V B; Sharma, Komal; Chuttani, Krishna; Mishra, A K; Dwivedi, A K (2015)

  Aim: The aim of the study was to develop a drug delivery system for specific targeting in colon cancer. We have developed Eudragit S-100 (ES) coated folic acid (FA) conjugated gliadin (Gd) delivery system for the effective ...
• Delivery of methotrexate executed by engineered polymeric micelles intended to improve chemotherapy 

  Kumar, Bijay; Meher, J G; Gupta, Annie; Pawar, V K; Singh, Yuvraj; Chourasia, M K (2014)

  Development of novel polymeric micelles incorporating methotrexate (MTX) was the objective of present investigation. Solvent evaporation and sonication methods were employed for formulation of micelles, which were optimized ...
• Engineered Nanocrystal Technology: in-vivo fate, targeting and applications in drug delivery 

  Pawar, V K; Singh, Yuvraj; Meher, J G; Gupta, Siddharth; Chourasia, M K (2014)

  Formulation of nanocrystals is a robust approach which can improve delivery of poorly water soluble drugs, a challenge pharmaceutical industry has been facing since long. Large scale production of nanocrystals is done by ...
• Preparation and characterization of depot injectable microspheres of centchroman using ethyl cellulose 

  Gupta, Varsha; Singh, Swati; Srivastava, Madhumita; Ahmad, Hafsa; Pachauri, S D; Khandelwal, Kiran; Dwivedi, Pankaj; Dwivedi, A K (2014)

  Context: Centchroman (Ormeloxifene) is a nonsteroidal SERM; popularly used as a contraceptive; hence controlled delivery systems become a favorable choice for its administration. Objective: The present work aimed at preparing ...
• An improved HPLC method for simultaneous estimation of isocurcumenol, ar-turmerone and α,β-turmerone in hexane soluble fraction of Curcuma longa and its formulations 

  Malasoni, Richa; Naqvi, Arshi; Srivastava, Akansha; Pandey, R R; Singh, Artee; Chaudhary, Madhuri; Paliwal, S K; Dwivedi, A K (2014)

  Curcuma longa (C. longa), a perennial herb, is a member of the Zingiberaceae (ginger) family and possesses a wide array of biological activity. Standardized hexane soluble extract of C. longa rhizomes [Herbal Medicament ...
• Dried Blood Spots: Concepts, Present Status and Future Perspectives in Bioanalysis 

  Sharma, Abhisheak; Jaiswal, Swati; Shukla, Mahendra; Jawahar Lal (2014)

  Over the past several years dried blood spot (DBS) sampling technique has emerged as a pertinent method in both qualitative and quantitative bioanalysis context. In DBS method, blood sample is directly soaked on to a paper ...

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