• Cofactor Biosynthetic Pathways in Mycobacterium tuberculosisas Potential Drug Targets 

  Pandey, Shilpika; Gaur, Sarthak; Topno, Neha; Chopra, Sidharth; Dasgupta, Arunava (2014)

  There are many chemotherapeutic interventions available for tuberculosis (TB) and are in use for more than five decades, but still there is an urgent need for novel drugs against new targets due to emergence of resistant ...
• Eravacycline: A Monograph 

  Chopra, Sidharth; Dasgupta, Arunava (2014)

  Eravacycline (TP-434) is a novel and fully synthetic, broad spectrum IV/oral antibiotic for treatment of complicated urinary tract infections and complicated intra-abdominal infections caused by multi-drug resistant ...
• Current approaches for new TB drugs 

  Pandey, Shilpika; Soni, Isha; Topno, Neha; Dasgupta, Arunava; Chopra, Sidharth (2014)

  Tuberculosis is essentially a curable disease but inspite of a WHO approved DOTS therapy, it still continues to ravage mankind. This situation is exacerbated by long course of chemotherapy, increasing drug resistance and ...
• Phosphorylation of Pyruvate Kinase A by Protein Kinase J leads to the altered growth and differential rate of intracellular survival of mycobacteria 

  Singh, D K; Singh, P K; Tiwari, Sameer; Singh, S K; Kumari, Ruma; Tripathi, D K; Srivastava, K K (2014)

  PknJ (Rv2088) is a serine / threonine protein kinase of mycobacteria which is present in Mycobacterium tuberculosis (MTB) but its gene is absent in Mycobacterium smegmatis (MS), a fast grower and non-pathogenic species of ...
• A monoclonal antibody against glycoproteins of Aspergillus fumigatus shows anti-adhesive potential 

  Kumar, Awanit; Shukla, P K (2015)

  There has been an increase in the cases of fungal resistance against many antifungal drugs and an effective alternative mode in the form of immunotherapy is being considered as new hope. The adhesion of Aspergillus fumigatus ...
• A simple robust enzymatic based high throughput screening method for antimicrobial peptides discovery against Escherichia coli. 

  Thirumalai, M K; Roy, Arpita; Sanikommu, Suma; Arockiaraj, Jesu; Pasupuleti, Mukesh (2014)

  The indiscriminate usage of antibiotics has created a major problem in the form of antibiotic resistance. Even though new antimicrobial drug discovery programs have been in place from last two decades, still we are ...
• A double recombinant Mycobacterium bovis BCG strain for screening of primary and rationale-based antimycobacterial compounds 

  Singh, Vandana; Biswas, R K; Singh, B N (2014)

  Conventional antimycobacterial screening involves CFU analysis which poses a great challenge due to slow growth of mycobacteria. Recombinant strains carrying reporter genes under the influence of constitutive promoters ...
• ‘Could repurposing existing drugs be an efficient protective method against microbial biologic threats?’ 

  Chopra, Sidharth (2013)
• New drugs for methicillin-resistant Staphylococcus aureus: an update 

  Kumar, Krishna; Chopra, Sidharth (2013)

  Methicillin-resistant S. aureus (MRSA) remains the leading cause of bacterial infections worldwide with a dwindling repertoire of effective antimicrobials active against it. This review aims to provide an update on novel ...
• Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase 

  Khan, S R; Singh, Supriya; Roy, K K; Akhtar, M S; Saxena, A K; Krishnan, M Y (2013)

  The ATP synthase of Mycobacterium tuberculosis is a validated drug target against which a diarylquinoline drug is under clinical trials. The enzyme is crucial for the viability both of actively replicating and non-replic ...
• Rv3080c regulates the rate of inhibition of mycobacteria by Isoniazid through FabD 

  Kumari, Ruma; Saxena, Richa; Tiwari, Sameer; Tripathi, D K; Srivastava, K K (2013)

  The mycobacterial FAS-II multienzyme complex has been identified to be a target of Ser/Thr protein kinases (STPKs) of Mycobacterium tuberculosis (MTB), with substrates, including the malonyl-CoA:ACP transacylase (FabD) and ...
• A Pharmacognostical Study of the Stem of Cissus quadrangularis Linn. 

  Madan, C L; Nayar, S L (1959)

  The macroscopic and microscopic characters'of the stem of Cissus quadrangularis Linn., which is used in the indigenous systems of medicine, are described.
• Alloxan Resistance of Albino Rats 

  De, U N; Mukherjee, S K (1959)

  The causes for the occasional resistance to the diabetogenic effect of alloxan in experimental diabetes of albino rats have been investigated. Studies made on rats receiving repeated diabetogenic dose of alloxan from the ...
• Studies on the Action of Makaradhwaja: Part IV -Effect on the Catalase Activity of Rat Liver Homogenate 

  Rao, K R K; Agarwala, S C (1959)

  The influence pf makaradhwaja has been studied on the catalase activity of rat liver homogenate and compared with that of red mercuric sulphide and mercuric chloride. Catalase activity is inhibited to the extent of 80·1, ...
• A Method of Absolute Count of Melanocytes in The Skin 

  Shukla, R C; Zaidi, S H; Mukerji, B (1959)
• Studies on the Action of Makaradhwaja: Part II- Influence on the Oxidation of Ascorbic Acid 

  Rao, K R K; Mukerji, B (1959)
• Studies on the Action of Makaradhwaja: Part III- Influence on the Oxidation of Tyrosine by Rat Liver Homogenate 

  Rao, K R K; Mukerji, B (1959)

  The influence of makaradhwaja on the oxidation of L-tyrosine by rat liver homogenate has been studied and compared with that of red mercuric sulphide, calomel and mercuric chloride. These compounds inhibit the oxidation ...
• The Therapeutic Activity of Some Sulphides, Quinazolones & Pyrimidines in Experimental Tuberculosis of Guinea-pigs 

  Gupta, S K; Mathur, I S; Mukerji, B (1959)

  A series of sulphides. pyrimidines and quinazolones have been screened against experimental tuberculosis in guinea-pigs. Only p,p'-diaminodiphenyl sulphide (D.D. sulphide) has been found comparable to Dapsone (DDS). Isoniazid ...
• Effect of α- Tocopherol on Serum Lipids & Lipoproteins in Experimental Cholesterol Atherosclerosis 

  Balkrishna; Chakravarti, R N; Zaidi, S H (1959)

  Parenteral administration of DL,α tocopherol acetate during the development of experimental atherosclerosis produced progressive hypercholesterolaemia and β lipoproteinaemia with a marked rise of C/P ratio and β cholesterol. ...
• Pharmacognostic Study of the 'Leaf & Root of Vitex negundo Linn 

  Madan, C L; Nayar, S L (1959)

  The macroscopic and microscopic characters of the leaf and root of Vite» negundo Linn., a commercial drug used in indigenous medicine in India, have been described.

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