• Krc 

  sheikh, Arshi (CSIR-CDRI, 2016)

  Tuberculosis, 1,2,3-Triazoles, antimycobacterial activity, molecular docking
• Synthesis of Enantiomerically Enriched Indolines and Tetrahydroisoquinolines from (S)-Amino Acid-Derived Chiral Carbocations: An Easy Access to (3S,4R)-Demethoxy-3-isopropyl Diclofensine 

  Manna, S K; Panda, Gautam (2014)

  Enantiomerically enriched indolines and tetrahydroisoquinolines were synthesized within 5 min to 2 h in high yields from easily accessible (S)-amino acids derived chiral carbocations. The diastereoselective Friedel-Crafts ...
• Asymmetric Assembly of Steroidal Tetracyclic Skeletons 

  Gupta, Preeti; Panda, Gautam (2014)

  Steroids have long played a vital role in the organic synthesis because of their unique structural design and associated biological properties. In recent years, asymmetric synthesis has emerged as a powerful tool for ...
• Substituent controlled reactivity switch: selective synthesis of alpha-diazoalkylphosphonates or vinylphosphonates via nucleophilic substitution of alkyl bromides with Bestmann-Ohira reagent 

  Pramanik, M M D; Chaturvedi, A K; Rastogi, Namrata (2014)

  We report a substituent controlled nucleophilic displacement of alkyl bromides with Bestmann-Ohira reagent yielding either dimethyl diazoalkylphosphonates or (E)-vinylphosphonates. The dimethyl diazoalkylphosphonates could ...
• Trisubstituted Methanes (TRSMs): Synthesis and Bioevaluation as Anti-malarials 

  Manna, S K; Singh, Priyanka; Mondal, Sankalan; Goyal, Manish; Bandyopadhyay, Uday; Panda, Gautam (2014)

  Focused libraries of Trisubstituted methanes (TRSMs) have been synthesized through Grignard reaction of aryl magnesium bromide with various carbaldehydes followed by Friedel-Crafts alkylation of diaryl carbinols with ...
• Synthesis of 4-substitutedimino-4H-benzo[d][1,3]thiazin-2-amines via palladium-catalysed isocyanide insertion in 2-bromophenylthioureas 

  Pandey, Garima; Bhowmik, Subhendu; Batra, Sanjay (2014)

  The palladium-catalysed isocyanide insertion in 2-bromophenylthioureas results into the formation of 4-substitutedimino-4H-benzo[d][1,3]thiazin-2-amines via C-S cross coupling reaction of the intermediate imidoylpalladium ...
• Formal acylamination of nitroalkenes in aqueous medium for the synthesis of 2-aryl-3-nitro-2,3-dihydro-quinolin-4(1H)-ones 

  Chaturvedi, A K; Rastogi, Namrata (2015)

  Formal acylamination of aromatic nitroalkenes with 2-aminobenzoyl benzotriazoles in aqueous methanol results into diastereoselective synthesis of 2-aryl-3-nitro-2,3-dihydro-quinolin-4(1H)-ones. The aliphatic nitroalkenes ...
• Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis 

  Sashidhara, K V; Singh, S P; Varshney, Salil; Beg, Muheeb; Gaikwad, A N (2014)

  In our efforts to develop safe and active chemical entities from nature, we first identified poliothrysoside (1), a phytoconstituent isolated from Flacourtia indica, possessing antidiabetic potential. Subsequently, fifteen ...
• Regioselective synthesis of Fused Imidazo[1,2-a] Pyrimidines via intramolecular C-N bond formation/6-endo-dig Cycloisomerization 

  Kumar, Atul; Kumar, Mukesh; Maurya, Shivam; Khanna, R S (2014)

  An efficient regioselective cascade synthesis of N-fused imidazo heterocycles has been developed. This cascade transformation proceeds via a transition-metal (copper/silver) catalyzed coupling reaction between 2-aminoben ...
• Synthesis of chiral chloroquine and its analogues as antimalarial agents 

  Sinhaa, Manish; Dolaa, V R; Sonib, Awakash; Agarwalb, Pooja; Srivastava, Kumkum; Haq, W; Puri, S K; Katti, S B (2014)

  In this investigation, we describe a new approach to chiral synthesis of chloroquine and its analogues. All tested compounds displayed potent activity against chloroquine sensitive as well as chloroquine resistant strains ...
• Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents 

  Sashidhara, K V; Rao, K B; Singh, Seema; Modukuri, R K; Teja, G A; Chandasana, Hardik; Shukla, Shubha; Bhatta, R S (2014)

  A series of amine substituted 3-phenyl coumarin derivatives were designed and synthesized as potential antidepressant agents. In preliminary screening, all compounds were evaluated in forced swimming test (FST), a model ...
• Recent Developments in the Side Chain Modified 4-Aminoquinolines As Antimalarial Agents 

  Dolaa, V R; Kondaparlaa, S R; Katti, S B (2014)

  The 4-aminoquinolines are considered to be one of the most vital synthetic antimalarial agents. However, control of malaria is threatened by inadequate resources and drug resistance particularly to this class of compounds. ...
• Directing Group Assisted Cu(II)-Catalyzed Ortho Carbonylation to Benzamide using AIBN 

  Khan, Bhuttu; Khan, Afsar Ali; Kant, Ruchir; Koley, Dipankar (2016)

  An efficient copper catalyzed regioselective C‒H bond carbonylation of benzamides has been developed using AIBN as traceless cyanating agent. The non-toxic and readily available AIBN was used for the carbonylative cyclization ...
• Discovery of 3,4,6-Triaryl-2-pyridones as Potential Anticancer Agents that Promote ROS-Independent Mitochondrial-Mediated Apoptosis in Human Breast Carcinoma Cells 

  Ansari, M I; Arun, Ashutosh; Hussain, M K; Konwar, Rituraj; Hajela, K (2016)

  A library of 3,4,6-triaryl-2-pyridones has been synthesized using multicomponent reaction (MCR) of substituted acetophenones, benzaldehydes and phenyl acetamides. All the synthesized compounds were evaluated for their ...
• Unusual conformational change in folded trimethylene/Leonard linker pyrazolo[3,4-d]pyrimidine analogue of theophylline compound due to structural changes 

  Avasthi, Kamlakar; Kant, Ruchir; Aswal, Sangeeta; Tewari, A K; Yadava, Umesh; Misra, U D; Maulik, P R (2015)

  The title compound, C29H28N8O4, 1,1′-(propane-1,3-diyl)bis(5-benzyl-7-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione) characterized by single crystal X-ray diffraction. It crystallizes in the centrosymmetric space ...
• Unsaturated phosphonates as Hauser Acceptors for the synthesis of phosphonylated dihydroxy naphthalenes and naphthoquinones 

  Chaturvedi, A K; Rastogi, Namrata (2016)

  The unsaturated phosphonates were utilized as Hauser acceptors successfully for the first time. The products phosphonylated 1,4-dihydroxynaphthalenes were isolated in good yields in short reaction time and were further ...
• Dithiocarbamate-Thiourea Hybrids Useful as Vaginal Microbicides Also Show Reverse Transcriptase Inhibition: Design, Synthesis, Docking and Pharmacokinetic studies 

  Bala, Veenu; Jangir, Santosh; Mandalapu, Dhanaraju; Gupta, Sonal; Chhonker, Y S; Lal, Nand; Kushwaha, Bhavana; Chandasana, Hardik; Krishna, Shagun; Rawat, Kavita; Maikhuri, J P; Bhatta, R S; Siddiqi, M I; Tripathi, Rajkamal; Gupta, Gopal; Sharma, V L (2015)

  Prophylactic prevention is considered as the most promising strategy to tackle STI/HIV. Twenty-five dithiocarbamate-thiourea hybrids (14-38) were synthesized as woman controlled topical vaginal microbicides to counter ...
• Design, Synthesis, Biological Screening and Molecular Docking Studies of Piperazine-Derived Constrained Inhibitors of DPP-IV for the Treatment of Type 2 Diabetes 

  Kushwaha, R N; Srivastava, Rohit; Mishra, Akansha; Rawat, A K; Srivastava, A K; Haq, W; Katti, S B (2015)

  Novel piperazine-derived conformationally constrained compounds were designed, synthesized, and evaluated for in vitro Dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. From a library of compounds synthesized, ...
• Palladium and copper-catalyzed ligand-free coupling of phenylhydrazines in water 

  Chauhan, Parul; Ravi, Makthala; Singh, Shikha; Raju, K S R; Bajpai, Vikas; Kumar, Brijesh; Wahajuddin; Yadav, P P (2014)

  An efficient protocol has been developed for the synthesis of biaryls via Pd/Cu catalyzed coupling of phenylhydrazines in water. Homo and cross couplings were successfully achieved in a ligand-free catalytic system, at ...
• Copper (II) catalyzed expeditious synthesis of furoquinoxalines through one-pot three-component coupling strategy 

  Naresh, Gunaganti; Kant, Ruchir; Narender, Tadigoppula (2014)

  Microwave assisted one-pot transformation has been developed for the synthesis of biologically significant poly-substituted furoquinoxalines in good to excellent yields through a copper (II) catalyzed three-component ...

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