• The Matrix Reloaded: CCN, Tenascin and SIBLING group of matricellular proteins in orchestrating cancer hallmark capabilities 

  Thakur, Ravi; Mishra, D P (2016)

  Matricellular proteins (MCPs) are the non-structural extracellular matrix (ECM) proteins with various regulatory functions. MCPs are critical regulators of ECM homeostasis and are often found dysregulated in various ...
• The dose-dependent effects of Asparagus adscendens roots (AARR) extract on the anabolic, reproductive and sexual behavioral activity in rats 

  Bansode, F W; Arya, K R; Singh, R K; Narender, T (2015)

  Context: Asparagus adscendens Roxb (Liliaceae) has a promising role in modulation of various disorders such as leucorrhea, diarrhea, dysentery, diabetes, senile pruritus, asthma, fatigue antifilarial, antifungal, spermatorrhea, ...
• Enhanced immunoprotective effects by anti-IL17 antibody translates to improved skeletal parameters under estrogen deficiency compared to anti- RANKL and anti-TNFα antibodies 

  Tyagi, A M; Mansoori, M N; Srivastava, Kamini; Khan, M P; Kureel, Jyoti; Dixit, Manisha; Shukla, Priyanka; Trivedi, Ritu; Chattopadhyay, Naibedya; Singh, Divya (2014)

  Activated T cell has a key role in the interaction between bone and immune system. T cells produce pro-inflammatory cytokines including, RANKL, TNF-α and IL-17, all of which augment osteoclastogenesis. RANKL and TNF- are ...
• Genetically engineered flavonol enriched tomato fruit modulates chondrogenesis to increase bone length in growing animals 

  Choudhary, Dharmendra; Pandey, Ashutosh; Adhikary, Sulekha; Ahmad, Naseer; Bhatia, Chitra; Bhambhani, Sweta; Trivedi, P K; Trivedi, Ritu (2016)

  Externally visible body and longitudinal bone growth is a result of proliferation of chondrocytes. In growth disorder, there is delay in the age associated increase in height. The present study evaluates the effect of ...
• Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6- Gingerol in cervical cancer cells 

  Rastogi, Namrata; Duggal, Shivali; Singh, S K; Porwal, Konica; Srivastava, V K; Maurya, Rakesh; Bhatt, M L B; Mishra, D P (2015)

  Human papilloma virus (HPV) expressing E6 and E7 oncoproteins, is known to inactivate the tumor suppressor p53 through proteasomal degradation in cervical cancers. Hence, a possible approach to p53 reactivation and induction ...
• Significant association of metabolic indices, lipid profile, and androgens levels with prostate cancer 

  Tewari, Reshu; Chhabra, Mohini; Natu, S M; Goel, Apul; Dalela, Divakar; Goel, M M; Singh, Rajender (2014)

  Aim: To compare the levels of metabolic indices, lipid profile, androgens, and prostate specific antigen between prostate cancer and BPH and between the grades of prostate cancer in a cross-sectional study. Materials and ...
• Alteration in endometrial proteins during early- and mid-secretory phases of the cycle in women with unexplained infertility 

  Manohar, Murli; Khan, Huma; Sirohi, V K; Das, Vinita; Agarwal, Anjoo; Pandey, Amita; Siddiqui, W A; Dwivedi, Anila (2014)

  Background: Compromised receptivity of the endometrium is a major cause of unexplained infertility, implantation failure and subclinical pregnancy loss. In order to investigate the changes in endometrial protein profile ...
• Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS - JNK - CHOP pathway 

  Trivedi, Rachana; Maurya, Rakesh; Mishra, D P (2014)

  Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent with cancer cell-selective cell death inducing effect. However, the major limitation in the usage of TRAIL as a chemotherapeutic ...
• M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease 

  Sarkar, Supriya; Gupta, Vikas; Kumar, Ajay; Chaudhary, Manoj; Diyundi, Subhash; Sehajpal, P K; Thangaraj, Kumarasamy; Singh, Rajender (2015)

  Background/Aims This study aimed at investigating if M235T polymorphism in the AGT gene and A/GI8-83 polymorphism in the REN gene correlate with the end stage renal disease (ESRD). Methods We analyzed one hundred and ...
• Targeting sperm post-ejaculation for value-added contraception 

  Gupta, Gopal; Jangir, Santosh; Sharma, V L (2014)

  The spermatogenesis is a precisely-timed cellular proliferation that takes place in the seminiferous tubules of testis and is meticulously regulated by gonadotrophins, androgens and temperature. Hormonal, non-hormonal and ...
• Epigenetics of Cancer Stem Cells: Pathways and Therapeutics 

  Shukla, Samriddhi; Meeran, S M (2014)

  Background Epigenetic alterations including DNA methylation and histone modifications are the key factors in the differentiation of stem cells into different tissue subtypes. The generation of cancer stem cells (CSCs) in ...
• Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention 

  Shukla, Samriddhi; Meeran, S M; Katiyar, S K (2014)

  The growing interest in cancer epigenetics is largely due to the reversible nature of epigenetic changes which tend to alter during the course of carcinogenesis. Major epigenetic changes including DNA methylation, chromatin ...
• Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse. 

  Maurya, V K; Chadchan, Sangappa; Kumar, Vijay; Mahfooz, Sahil; Singh, Archana; Singh, Rajender; Jha, R K (2014)

  Background Polycystic ovarian syndrome (PCOS) is characterized by the presence of multiple follicular cysts, giving rise to infertility due to anovulation. This syndrome affects about 10% of women, worldwide. The exact ...
• miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation 

  Kureel, J.; Dixit, M.; Tyagi, A M; Mansoori, M N; Srivastava, K; Raghuvanshi, A; Maurya, R; Trivedi, R; Goel, A; Singh, Divya (2014)

  MicroRNAs (miRNAs) are short non-coding RNAs that interfere with translation of specific target mRNAs and thereby regulate diverse biological processes. Recent studies have suggested that miRNAs might play a role in ...
• Combining a synthetic spermicide with a natural trichomonacide for safe, prophylactic contraception 

  Jain, Ashish; Kumar, Lokesh; Kushwaha, Bhavana; Sharma, Monika; Pandey, Aastha; Verma, Vikas; Sharma, Vikas; Singh, Vishal; Rawat, Tara; Sharma, V L; Maikhuri, J P; Gupta, Gopal (2014)

  Study question: Can a specifically acting synthetic spermicide (DSE-37) be combined with a natural microbicide (saponins) for safe, prophylactic contraception? Summary answer: A 1:1 (w/w) combination of DSE-37 and Sapindus ...
• Isaptent - A New Cervical Dilator 

  Khanna, N M; Sarin, J P S; Nandi, R C; Singh, Satyawan; Setty, B S; Kamboj, V P; Dhawan, B N; Singh, L; Kutty, Devaki; Engineer, A D (1980)

  A new cervical dilator, Isaptent, was prepared from granulated Plantago ovata (Isapgol) seed husk. It was evaluated in a multicentric clinical trial for dilatation of the cervix in subjects opting for medical termination ...
• Trace Elements in Prostatic Tissue and Plasma in Prostatic Diseases of Man 

  Jafa, Ajit; Mahendra, N M; Chowdhury, A R; Kamboj, V P (1980)

  Zinc, copper and iron have been determined in prostatic Tissue and plasma of subject presenting various prostatic disorders namely benign hyperplasia, fibrous growth, chronic prostatis and malignancy. In malignancy, zinc ...
• Succinic Dehydrogenases in the Silk-Glands of Bombyx Mor. 

  Gupta, B L; Kamboj, V P (1961)

  The histochemicallocalization of succinic de hydrogenases has been studied in the silk-glands of the various instars of Bombyx mori. The probable significance of the succinic dehydrogenase actiyity in the secretory metabolism ...
• Secular changes in the semen quality in India during past 33 years 

  Dama, M S; Singh, Rajender (2012)

  Several studies have suggested a change in semen quality over last 60 years in many regions of the world, but such studies are lacking for Indian population. In the present study, we aimed at investigating if semen quality ...
• Potent Natural Aphrodisiacs For The Management Of Erectile Dysfunction And Male Sexual Debilities 

  Singh, A P; Singh, Rajender (2012)

  Drugs derived from natural resources have always been considered safe and overall health promoting, since in addition to the active ingredients required for treating the disorder, they also provide various nutritional ...

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