β-Carboline represents the core unit of several alkaloids and bioactive agents. This review assimilates the reports pertaining to the synthetic applications of 1-formyl-9H-β-carbolines for the synthesis of substituted and ...

Syntheses of a variety of aza-polycycles employing 2-(N-allylaminomethyl)cinnamaldehydes derived from Morita-Baylis-Hillman adducts of acrylates via intramolecular 1,3-dipolar cycloaddition, or Aza-Diels-Alder or domino ...

Ormeloxifen is a non-steroidal selective estrogen receptor modulator (SERM) and has been shown to possess anticancer activities in breast and uterine cancer. Here, we show that ormeloxifen induces apoptosis in dose dependent ...

Antimalarials based on the 4-aminoquinoline-schiff base hybrid coupled with oxalamide functionality as linker are designed and synthesized. The molecules were evaluated for their antiplasmodial activity against ...

The 4-Hydroxyisoleucine (4-HIL), an unusual amino acid isolated from the seeds of Trigonella foenum-graecum was investigated for the metabolic effects to ameliorate free fatty acid-induced insulin resistance in skeletal ...

During synthesis aimed at obtaining 4-beta-chloroethylamino and 4-bis-beta-chloroethylamino pyrimidines, it has been found that treatment of 2-chloro-4-bis-beta-hydroxyethylaminopyrimidine with hydrochloric acid or of ...

Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and alpha-glucosidase ...

We report a new bone anabolic and anti-catabolic pterocarpan 9-demethoxy-medicarpin (DMM) for the management of postmenopausal osteoporosis. DMM promoted osteoblast functions via activation of P38MAPK/BMP-2 pathway and ...

The membrane phospholipid organisation in the red cells of humans suffering from chronic myeloid leukaemia has been analysed using the amino-group labelling reagent trinitrobenzenesulphonic acid and the nuid-sensing ...