• Adipocyte Transdifferentiation and its Molecular Targets 

  Rajan, Sujith; Gupta, Abhishek; Beg, Muheeb; Shankar, Kripa; Srivastava, Ankita; Varshney, Salil; Kumar, Durgesh; Gaikwad, A N (2014)

  According to World Health Organization obesity is defined as an excessive accumulation of fat, which increases risk of other metabolic disorders such as insulin resistance, dyslipidemia, hypertension, cardiovascular diseases, ...
• Epigenetic regulation of G Protein Coupled Receptor signaling and its implications in psychiatric disorders 

  Dogra, Shalini; Sona, Chandan; Kumar, Ajeet; Yadav, P N (2016)

  G protein-coupled receptors (GPCRs) act as a relay center through which extracellular signals, in the form of neurotransmitters or therapeutics, are converted into an intracellular response, which ultimately shapes the ...
• Curcuma oil reduces endothelial cell mediated inflammation in post myocardial ischemia /reperfusion in rats 

  Manhas, A; khanna, V; Prakash, P; Goyal, D; Malasoni, Richa; Naqvi, Arshi; Dwivedi, Anila; Dikshit, Madhu; Jagavelu, Kumaravelu (2014)

  Endothelial cells initiated inflammation persisting in post myocardial infarction needs to be controlled and moderated for avoiding fatal complications. Curcuma oil (C.oil, Herbal Medicament) a standardized hexane soluble ...
• Withania somnifera shows protective effect in monocrotaline-induced pulmonary hypertension 

  Kaur, Gurpreet; Singh, Neetu; Samuel, S S; Bora, H K; Sharma, Sharad; Pachauri, S D; Dwivedi, A K; Siddiqui, H H; Hanif, Kashif (2015)

  Context: Withania somnifera (Linn.) Dunal (Solanaceae), a clinically used herbal drug in Ayurveda, shows potent antioxidant, anti-inflammatory, pro-apoptotic, and cardioprotective effects. However, the efficacy of W. ...
• Effect of homeopathic medicine Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats 

  Hanif, Kashif; Kumar, Manoj; Singh, Neetu; Shukla, Rakesh (2015)

  Background: Lycopodium clavatum (Lyc) is a widely used homeopathic medicine for the liver, urinary and digestive disorders. Recently, Acetyl Cholinesterase (AchE) inhibitory activity has been found in Lyc alkaloid extract, ...
• Curcuma Oil ameliorates insulin resistance and associated thrombotic complications in hamster and rat 

  Singh, Vishal; Jain, Manish; Misra, Ankita; Khanna, Vivek; Prakash, Prem; Malasoni, Richa; Dwivedi, A K; Dikshit, Madhu; Barthwal, M K (2015)

  Background and objectives: Curcuma Oil (C. Oil) isolated from Turmeric (Curcuma longa L.) has shown neuroprotective, anti-cancer, anti-oxidant and anti-hyperlipidemic effect in experimental animal models, yet its effect ...
• Curcumal Oil Attenuates Accelerated Atherosclerosis and Macrophage Foam Cell Formation by Modulating Genes Involved in Plaque Stability, Lipid Homeostasis and Inflammation 

  Singh, Vishal; Rana, Minakshi; Jain, Manish; Singh, Niharika; Naqvi, Arshi; Malasoni, Richa; Dwivedi, A K; Dikshit, Madhu; Barthwal, M K (2015)

  In the present study, the anti-atherosclerotic effect and underlying mechanism of curcuma oil (C.oil), a lipophilic fraction from turmeric (Curcuma longa L.), was evaluated in a hamster model of accelerated atherosclerosis ...
• A Withanolide Coagulin-L Inhibits Adipogenesis Modulating Wnt/βCatenin and Cell Cycle Arrest in Mitotic Clonal Expansion 

  Beg, Muheeb; Chauhan, Parul; Varshney, Salil; Shankar, Kripa; Rajan, Sujith; Saini, Deepika; Srivastava, M N; Yadav, P P; Gaikwad, A N (2014)

  Obesity is a result of adipocyte hypertrophy followed by hyperplasia. It is a risk factor for several metabolic disorders such as dyslipidemia, type-2 diabetes, hypertension, and cardiovascular diseases. Coagulanolides, ...
• PKCδ-IRAK1 axis regulates oxidized LDL induced IL-1β prod uction in monocytes 

  Tiwari, R L; Singh, Vishal; Singh, Ankita; Rana, Minakshi; Verma, Anupam; Kothari, Nikhil; Kohli, Monica; Bogra, Jaishri; Dikshit, Madhu; Barthwal, M K (2014)

  Present study examined the role of IL-1R-associated kinase (IRAK) and protein kinase C (PKC) in Oxidized LDL (Ox-LDL) induced monocyte IL-1β production. In THP1 cells Ox-LDL induced time dependent secretory IL-1β, IRAK1 ...
• Rohitukine inhibits in vitroadipogenesis arresting mitotic clonal expansionand improves dyslipidemia in vivo 

  Varshney, Salil; Shankar, Kripa; Beg, Muheeb; Balaramnavar, V M; Mishra, S K; Jagdale, Pankaj; Srivastava, Shishir; Chhonker, Y S; Lakshmi, Vijai; Chaudhari, B P; Bhatta, R S; Saxena, A K; Gaikwad, A N (2014)

  We developed a common feature pharmacophore model using known anti-adipogenic compounds (CFPMA). We identified rohitukine, a reported chromone anti-cancer alkaloid as potential hit through in silico mapping of in-house ...
• A time course study on prothrombotic parameters and their modulation by anti-platelet drugs in hyperlipidemic hamsters 

  Singh, Vishal; Jain, Manish; Prakash, Prem; Misra, Ankita; Khanna, Vivek; Tiwari, R L; Keshari, R S; Singh, Shivendra; Dikshit, Madhu; Barthwal, M K (2011)

  Present study was undertaken to assess the chronology of major pathological events associated with high cholesterol (HC) diet and their modulation by anti-platelet drugs. Male Golden Syrian hamsters were fed HC diet up to ...
• Evaluation of the antipsychotic potential of Panax quinquefolium in ketamine induced experimental psychosis model in mice 

  Chatterjee, Manavi; Singh, Seema; Kumari, Reena; Verma, A K; Palit, Gautam (2012)

  Herbal medicines play an important role in health care programme worldwide. The search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has progressed significantly in the past decade and their ...
• Pharmacognosy of Piplamul' - the Root and Stem of Piper Longum Linn. 

  Bisht, B S (1963)
• Pharmacognostical Study of the Bark of Erythrina variegata Linn. var. orientalis (Linn.) Merrill 

  Bisht, B S; Nayar, S L (1959)

  The macroscopic and microscopic characters of the bark of Erythrina variegata Linn. var. orientalis (Linn.) Merrill are described.
• Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition 

  Keshari, R S; Jyoti, Anupam; Dubey, Megha; Kothari, Nikhil; Kohli, Monica; Bogra, Jaishri; Barthwal, M K; Dikshit, Madhu (2012)

  Neutrophils (PMNs) and cytokines have a critical role to play in host defense and systemic inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) have been shown to extracellularly kill pathogens, and ...
• Stabilization of Vitamins in Pharmaceutical Preparations: Part l-lnfluence of Common Vehicles on the stability of Vitamins A, B1 & C 

  Uprety, M C; Rao, V K M (1959)

  The stabilities afforded by different combinations of bases like sugar syrup, propylene glycol, glycerol, sorbitol, etc., to vitamins A, B, and C at 37°C. have been studied. Sorbitol-propylene glycol-glycerol-ethyl alcohol ...
• Inhibition of central Angiotensin Converting Enzyme ameliorates scopolamine induced memory impairment in mice: role of cholinergic neurotransmission, cerebral blood flow and brain energy metabolism 

  Tota, S K; Nath, Chandishwar; Najmi, A K; Shukla, Rakesh; Hanif, Kashif (2012)

  Evidences indicate that inhibition of central Renin angiotensin system (RAS) ameliorates memory impairment in animals and humans. Earlier we have reported involvement of central angiotensin converting enzyme (ACE) in ...
• Neurochemical and molecular characterization of ketamine induced experimental psychosis model in mice 

  Chatterjee, Manavi; Verma, Rajkumar; Ganguly, Surajit; Palit, Gautam (2012)

  Ketamine, an NMDA receptor antagonist has been shown to induce aberrant behaviour phenotypes in rodents, some of which are known to simulate the behaviour abnormalities observed in patients suffering from schizophrenia. ...
• Influence of p p- diaminodiphenyl Sulphone Resistant Mutant of Mycobacterium Tuberculosis Var. hominis Strain H37 Rv In Experimental Tuberculosis of Guinea-Pigs & Mice 

  Gupta, S K; Kar, K; Chatterji, J (1959)
• Antibiotic X-I285: Part I-Isolation from a Streptomyces Species 

  Shete, K; Vora, V C (1959)

  An apparent mixture of antibiotic substances, designated X-1285, has been isolated from a Streptomyces species, whose cultural characteristics are described. X-1285 is active against both gram-positive and gram-negative ...

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