Medicinal and Process Chemistry: Recent submissions

Now showing items 401-420 of 531

Studies in Possible Oral Hypoglycaemic Agents : Part V- Synthesis of Carbamoylindoles, Carbamoylisoindolines, 3- Indolylethyl Urea (or Thiourea) & 2- Isoindolinylpropyl Urea (or Thiourea) Derivatives & Their Biological Activity

Shoeb, A; Popli, S P; Mukerjee, S K; Dhar, M L (1967)

The synthesis of a number of carbamoylindoles and carbamoylisoindolines as well as 3-indolylethylurea or thiourea derivatives and 2- isoindolinylpropyl ureas and thioureas is described. Some of the indole derivatives ...
Phenol Oxidation and Biostnthesis.Part XII. Stereochemical Studies Related to the Biosynthesis Of the Morphine Alkaloids

Barton, D H R; Bhakuni, D S; James, R; Kirby, G W (1967)

Ozonolysis of tritiated Salutaridinols-I and-II has afforded glyceric acids whose absolute confiurations have been determined by the isotope dilution method.In this way the stereochemistry of salutaridinol-I, the Precursor ...
Solid - Phase Peptide Synthesis of [L--Alanine3-L-isoleucine5] angiotensin II

Khosla, M C; Smeby, R R; Bumpus, F M (1967)

[Alanine3-L-isoleucine5] angiotensin II was synthesized by stepwise elongation of the peptide chain on copolystyrene-divinylbenzene using dicyclohexylcarbodiimide as the condensing agent. The purified end product was ...
Apparatus for Solid-Phase Peptide Synthesis

Khosla, M C; Smeby, R R; Bumpus, F M (1967)

The apprataus, designed for solid phase peptide synthesis, consist of a round-bottom flask,rocked on a wrist-shaker,and fitted with a special dropping funnel and a fritted filter disc embedded with in the flask.The dropping ...
Stereoselective synthesis of homoallyl nitroalkane derivatives via base-promoted regioselective decarboxylation in Baylis-Hillman derivatives

Nayak, Maloy; Batra, Sanjay (2009)

The regioselective decarboxylation during the saponification of the nitroalkanoates synthesized from the Baylis-Hillman acetates of acrylates to stereoselectively afford homoallyl nitroalkane is described. In contrast the ...
Reductive-cyclization-mediated syntheses of fused polycyclic quinolines from the Baylis-Hillman adducts of acrylonitrile: Scope and limitations

Singh, Virender; Hutait, Samiran; Batra, Sanjay (2009)

Syntheses of a variety of polycyclic quinolines are described. The target molecules were obtained in two steps through initial reductive cyclization succeeded by another intramolecular cyclization in the allyl amines ...
First synthesis of allyl isonitriles from Baylis-Hillman adducts and their syn-thetic application for obtaining substituted imidazo[1,2-a]pyridine and dibenzoazulene systems

Nayak, Maloy; Kanojiya, Sanjeev; Batra, Sanjay (2009)

First report of stereoselective synthesis of substituted allyl isonitriles from the primary allyl amines generated from the Baylis-Hillman adduct and its utilization in a robust IMCR to afford substituted imidazo[1,2-a]pyridine ...
Synthesis of 2-amino-3,4-dihydroquinazolines and imidazo[2,1-b]quinazoline-2-ones

Mishra, Amita; Batra, Sanjay (2009)

A facile method for the synthesis of 2-amino-3,4-dihydroquinazolines from the Baylis-Hillman derivatives has been disclosed. The protocol involves the sequential SN2-reaction of a primary amine on the Baylis-Hillman acetate ...
Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines

Mishra, A; Srivastava, K; Tripathi, R; Puri, S K; Batra, Sanjay (2009)

Syntheses and in vitro antimalarial evaluation of 42 new thioureido quinazolines have been carried out. Several analogs showed promising antimalarial effect in the in vitro investigation against chloroquine-sensitive 3D7 ...
Search for new pharmacophores for antimalarial activity (Part II): Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines

Madapa, Sudharshan; Tusi, Zehra; Mishra, A; Srivastava, K; Pandey, S K; Tripathi, R; Puri, S K; Batra, Sanjay (2009)

Synthesis of new 6-ureido-4-anilinoquinazolines have been accomplished and their in vitro antimalarial activity against chloroquine-sensitive P. falciparum have been examined. Out of 64 compounds evaluated, the IC50 of 16 ...
Search for new pharmacophores for antimalrial activity (Part I): Synthesis and antimalarial activity of new 2-methyl-6-ureido-4-quinolinamides

Madapa, Sudarshan; Tusi, Zehra; Sridhar, D; Kumar, A; Siddiqi, M I; Srivastava, K; Rizvi, A; Tripathi, R; Puri, S K; Keshava, G B Shiva; Shukla, P K; Batra, Sanjay (2009)

A total of 80 new 2-methyl-6-ureido-4-quinolinamides were synthesized and evaluated for their anitmalarial activity. Several analogs elicited the antimalarial effect at MIC of 0.25 mg/mL against the chlooquine-sensitive ...
Advances in the Baylis-Hillman Reaction-assisted Synthesis of Cyclic Frameworks

Singh, Vijay; Batra, Sanjay (2008)

Acquiring the capability to access structurally complex and diverse molecules through simple starting substrates has been one of the underlying principles of chemical research. These diverse compounds are desired in order ...
A facile route to the synthesis of pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from Baylis-Hillman adducts

Nag, Somnath; Mishra, Amita; Batra, Sanjay (2008)

A highly simplified approach for the generation of substituted pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from the Baylis-Hillman adducts is described. Sequential reductive alkylation of the ...
Advances in the syntheses of quinoline and quinoline-annulated ring systems

Madapa, Sudharshan; Tusi, Zehra; Batra, Sanjay (2008)

Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and electronics is well established. As ...
A versatile synthesis of dihydropyrimidinone c-nucleosides

Mishra, R C; Katiyar, Diksha; Tewari, Neetu; Tripathi, R P (2005)

A versatile syntheses of N-aryl dihydropyrimidinone C-nucleosides (20-29) is described. Glycosyl amino esters (3-9), obtained by reductive arylation of glycosyl amino esters 1 and 2, on condensation with different isocyanates ...
Fighting Tuberculosis: An old disease with new challenges

Tripathi, R P; Tewari, Neetu; Dwivedi, Namrata; Tiwari, V K (2005)
Synthesis and Antitubercular Activities of bis-glycosylated Diamino alcohols

Tripathi, R P; Tiwari, V K; Tewari, N; Katiyar, D; Saxena, N; Sinha, S; Gaikwad, A; Srivastava, A; Chaturvedi, Vinita; Manju, Y K; Srivastava, R; Srivastava, B S (2005)

Conjugate addition of diamines to glycosyl olefinic esters 1a and 1b followed by reduction of resulting bis-glycosyl β-amino esters (2-7 and 14-19) with lithium aluminium hydride led to the respective glycosyl amino alcohols ...
An efficient regioselective synthesis of functionalized biphenyls via sequential reactions of aromatic aldehydes and β-keto esters or ketones

Sharma, Anindra; Pandey, Jyoti; Tripathi, R P (2009)

Knoevenagel/ Michael/ Aldol reactions of aromatic aldehydes and β-keto esters/ketones in a sequential manner yielded the intermediate cyclohexanones in good yields. The latter on oxidative aromatization with iodine afforded ...
Solution phase synthesis of a library of carbapeptide analogues based on glycosylamino acid scaffolds, their in silico screening and antimicrobial evaluation

Pandey, Jyoti; Sharma, Anindra; Tiwari, Vinod K; Dube, Divya; Ramachandran, Ravishankar; Chaturvedi, Vinita; Sinha, Sudhir; Mishra, Nripendra N; Shukla, P K; Tripathi, R P (2009)
Synthesis and antitubercular screening of imidazole derivatives

Pandey, Jyoti; Tiwari, Vinod K; Verma, Shyam S; Chaturvedi, Vinita; Bhatnagar, Shalini; Sinha, Sudhir; Gaikwad, A N; Tripathi, R P (2009)

A series of imidazole based compounds were synthesized by reacting simple imidazoles either with alkyl halides in presence of tetrabutylammonium bromide (TBAB) or by conjugate addition of imidazoles to ethyl acrylate or ...

Now showing items 401-420 of 531

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