Abstract:
A facile method for the synthesis of 2-amino-3,4-dihydroquinazolines from the Baylis-Hillman derivatives has been disclosed. The protocol involves the sequential SN2-reaction of a primary amine on the Baylis-Hillman acetate of 2-nitrobenzaldehyde, CNBr-mediated nitrile addition and Fe-AcOH-promoted reductive cyclization. The approach has been extended for constructing imidazo[2,1-b]quinazoline-2-ones and imi-dazo[2,1-b]qinazolines in one pot.
