Abstract:
A versatile syntheses of N-aryl dihydropyrimidinone C-nucleosides (20-29) is described. Glycosyl amino esters (3-9), obtained by reductive arylation of glycosyl amino esters 1 and 2, on condensation with different isocyanates afforded respective ureidyl derivatives (10-19) in good to quantitative yields. The latter on cyclative amidation with a combination of DBU/ tetra butyl ammonium bromide/ 4Å MS gave the respective nucleosides (20-29) in good yields.
