Abstract:
A series of imidazole based compounds were synthesized by reacting simple imidazoles either with alkyl halides in presence of tetrabutylammonium bromide (TBAB) or by conjugate addition of imidazoles to ethyl acrylate or glycosyl olefinic ester. The synthesized compounds were screened against M. tuberculosis where compound 17 exhibited good in vitro antitubercular activity that may serve as a lead for further optimization.
