Abstract:
A highly simplified approach for the generation of substituted pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from the Baylis-Hillman adducts is described. Sequential reductive alkylation of the primary allyl amine with 2-nitrobenzaldehyde, reduction of the aromatic nitro group with In, CNBr-promoted intramolecular cyclization followed by NaOMe-mediated another intramolecular cyclization furnish the title compounds.
