Medicinal and Process Chemistry: Recent submissions

Now showing items 81-100 of 531

Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi

Sashidhara, K V; Rao, K B; Kushwaha, Vikas; Modukuri, R K; Verma, Richa; Murthy, P K (2014)

Here we report the synthesis of novel chalcone-thiazole compounds and their antifilarial activity. The antifilarial properties of these hybrids were assessed against microfilariae as well as adult worms of Brugia malayi. ...
Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells

Chauhan, S S; Singh, A K; Meena, Sanjeev; Lohani, Minaxi; Singh, Akhilesh; Arya, R K; Cheruvu, S H; Sarkar, Jayanta; Gayen, J R; Datta, Dipak; Chauhan, P M S (2014)

A series of novel β-carboline based chalcones was synthesized and evaluated for their cytotoxic activity against a panel of human cancer cell lines. Among them we found that two of the compounds 7c and 7d, showed marked ...
Palladium-Catalyzed Tandem Intramolecular Oxy/Amino-Palladation/Isocyanide Insertion: Synthesis of α-Benzofuranyl/Indolylacetamides

Thirupathi, Nuligonda; Babu, M H; Dwivedi, Vikas; Reddy, M S (2014)

Anovel palladium-catalyzed approach to 2-benzofuranyl/indolylacetamides from 1-(o-hydroxy/aminophenyl)propargylic alcohols and isocyanides is described. The reaction proceeds through a cascade that includes oxy/amino-palladation, ...
Tandem Cu-Catalyzed Ketenimines formation and Intramolecular Nucleophile Capture: Synthesis of 1,2-dihydro-2-Iminoquinolines from 1-(o-acetamidophenyl)-Propargyl Alcohols

kumar, G R; Kumar, Y K; Kant, Ruchir; Reddy, M S (2014)

The copper catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl)-propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2-im ...
Neoflavonoids as potential osteogenic agents from Dalbergia sissoo heartwood

Kumar, Padam; Kushwaha, Priyanka; Khedgikar, Vikram; Gautam, Jyoti; Choudhary, Dharmendra; Singh, Divya; Trivedi, Ritu; Maurya, Rakesh (2014)

The present study was undertaken to investigate and rationalize the in-vitro antiosteoporotic activity of neoflavonoids, isolated from Dalbergia sissoo heartwood. Neoflavonoids were isolated using extensive column ...
Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine

Avasthi, Kamlakar; Shukla, Lakshmi; Kant, Ruchir; Ravikumar, Krishnan (2014)

Abstract Butylidene linker models 1-(2-(2,6-dimethylsulfanyl-9H-purin-9-yl)-2-methylenepropane-4,6-dimethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine, (XI), C18H20N8S4, 7,7′-(2-methylenepropane-1,3-diyl)bis(3-methyl-2-methyl ...
Recent advances in the synthesis, chemical transformations and pharmacological studies of some important dietary spice’s constituents

Singh, V K; Yadav, Pragya; Tadigoppula, Narender (2014)

Chemoprevention, a relatively new and promising strategy to prevent various human disorders, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process ...
Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones

Gupta, P K; Hussain, M K; Asad, Mohd.; Kant, Ruchir; Mahar, Rohit; Shukla, S K; Hajela, Kanchan (2014)

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl ...
Microwave Assisted [RuCl2(p-cymene)2]2 Catalyzed Regioselective Endo-Tandem Cyclization Involving Imine and Alkyne Activation: An Approach to benzo[4,5]imidazo[2,1-a]pyridine Scaffold

Manna, S K; Panda, Gautam (2014)

A microwave assisted efficient route to the synthesis of benzimidazole fused heterocycles through metal catalyzed endo-cyclization strategy involving imine and alkyne activation has been developed. In the presence of ...
New convenient synthesis of fluorescent 1,8-Naphthyridines and their metal- sensing properties

Goel, Atul; Nag, Pankaj; Umar, Shahida (2014)

A new efficient approach to a series of highly fluorescent non-aggregating donor-acceptor [1,8]-naphthyridines is described. Photophysical properties of [1,8]-naphthyridines revealed that the presence of donor-acceptor ...
An alternate route to substituted 6,7-dihydro 5H-dibenz[c,e]azepines from allylbenzamides derived from the Morita-Baylis-Hillman adducts

Bhowmik, Subhendu; Bhattacharyya, Soumya; Batra, Sanjay (2014)

An acid-catalyzed modular synthesis of substituted 5H-dibenz [c,e]azepines from a biaryl allyl benzamides prepared from the MBH adducts via a cascade dearoylation and intramolecular cyclization is described. The utility ...
Modelling Biding Affinity of Steroids to Zebrafish Sex Hormone Binding Globulin

Saxena, A K; Devillers, J; Pery, A R R; Beaudouin, R; Balaramnavar, V M; Ahmed, S (2014)

The circulating endogenous steroids bound to a highly specific sex hormone-binding globulin (SHBG) and in lower-affinity to the proteins like the corticosteroid-binding protein and albumin in vertebrate including fish are ...
Design and synthesis of lupeol analogues and their glucose uptake stimulatory effect in L6 skeletal muscle cells

Khan, M F; Maurya, C K; Dev, Kapil; Arha, Deepti; Rai, A K; Tamrakar, A K; Maurya, Rakesh (2014)

Structure modifications of lupeol at the isopropylene moiety have been described via allylic oxidation using selenium dioxide. The antidiabetic efficacy of lupeol analogues were evaluated in vitro as glucose uptake stimulatory ...
Rational design and synthesis of novel thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors

Murugesan, Vanangamudi; Makwana, Nandini; Suryawanshi, Rahul; Saxena, Reshu; Tripathi, Rajkamal; Paranjape, Ramesh; Kulkarni, Smita; Katti, S B (2014)

A series of novel thiazolidin-4-one analogues, characterized by different substitution patterns at positions C-2 and N-3 of the thiazolidin-4-one scaffold for anti-HIV-1 activity has been investigated. Most of the compounds ...
A rapid entry to amino acids derived diverse 3,4-dihydropyrazines and ihydro[1,2,3]triazolo[1,5-a]pyrazines through 1,3-dipolar cycloaddition

Bera, Saurav; Panda, Gautam (2014)

An efficient, general and practical synthesis of diverse 3,4-dihydropyrazines, 6,7-dihydro-[1,2,3]triazolopyrazines and 7,8-dihydro-[1,2,3]triazolodiazepines through intramolecular 1,3-dipolar cycloaddition from amino acids ...
Concise synthesis of the repeating units of the cell wall lipopolysaccharide of Azospirillumbrasilense SR80†

Mandal, P K; Dhara, Debashis; Misra, A K (2014)

Synthesis of a branched trisaccharide and a branched tetrasaccharide related to the repeating units of the cell wall lipopolysaccharide of Azospirillumbrasilense SR80 as their p-methoxyphenyl (PMP) glycosides has been ...
Deoxysugars as antituberculars and alpha mannosidase inhibitors

Kashyap, Vivek; Sharma, Smriti; Singh, Vinayak; Sharma, S K; Saquib, Mohammad; Srivastava, Ranjana; Shaw, A K (2014)

A promising modified sugar molecule was identified which was active against MDR strains of Mycobacterium tuberculosis suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited ...
Multicomponent Diversity-Oriented Synthesis of Symmetrical and Unsymmetrical 1,4-dihydropyridines in Recyclable Glycine Nitrate (GlyNO3) Ionic Liquid: A Mechanistic Insight Using Q-TOF, ESI-MS/MS**

Kumar, Rajesh; Andhare, N H; Shard, Amit; Richa; Sinha, A K (2014)

Multicomponent reactions are eye-catching strategies to generate chemically diverse set of multifunctionalized heterocyclic motifs with high atom economy manner which render the transformations green. These strategies can ...
Molecular iodine promoted divergent synthesis of benzimidazoles, benzothiazoles and 2-benzyl-3-phenyl-3, 4- dihydro-2H-benzo[e] [1, 2, 4] thiadiazines

Naresh, Gunaganti; Kant, Ruchir; Narender, Tadigoppula (2014)

An unprecedented formation of a new class of 2-benzyl-3-phenyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazines has been discovered during the course of benzimidazoles, benzothiazole synthesis, through the molecular iodine ...
Investigation of Ugi-4CC derived 1H-tetrazol- 5-yl-(aryl) methyl piperazinyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid: Synthesis, Biology and 3D-QSAR Analysis

Chauhan, Kuldeep; Singh, Pratiksha; Kumar, Vikash; Shukla, P K; Siddiqi, M I; Chauhan, P M S (2014)

Novel series of 7-piperazinylquinolones with tetrazole derivatives were synthesized and evaluated for their antibacterial activity against various strains of Staphylococcus aureus. All the synthesized compounds showed ...

Now showing items 81-100 of 531

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