A method to prepare 3-substituted-2-formyl indole derivatives from N-Boc o-aminoarylketones and ethoxyacetylene through a cascade of reactions in a single operation that included a metal/catalyst free nucleophile triggered ...

An efficient ligand/base and oxidant-free copper(I) catalyzed intermolecular direct alkynylation (IDA) strategy has been developed for the synthesis of α-alkynylated pyrrolidine-oxindole derivatives using cyclic diketones, ...

A one-pot protocol for the diversity-oriented synthesis of two indole-based annulated polyheterocycles keto indolo quinoxalines and indolo triazolo quinoxalines has been described. This methodology allows synthesis of two ...

An efficient diversity oriented synthetic approach to annulated 9H-benzo[b]pyrrolo[1,2-g][1,2,3]triazolo[1,5-d][1,4] diazepines has been developed using a Sc(OTf)3 catalyzed two component tandem C-2 functionalization-intramolecular ...

A direct Mannich type diastereoselective biomimetic cyclization using acetal as pro-nucleophile leading to the hydroxymethyl substituted bicyclic framework of various bicyclic alkaloids is presented. Following this protocol, ...

The intramolecular aminopalladation reaction of L-serine derived β-hydroxy--alkenylamines undergoes 5-endo-trig cyclization to furnish pyrrolidine rings in high yields. The pyrrolidine thus obtained were elaborated to the ...

An efficient total synthesis of 18 membered macrolactone, (+)-Aspicilin (lichen macrolide) has been achieved in 12 linear steps and 10.2% overall yield from carbohydrate based building block D-glucal. Highlights of the ...

The copper-catalyzed cascade reaction comprising of condensation/ α-arylation between 2-halobenzaldehydes and α-amino acid esters provides a straightforward methodology for the efficient synthesis of 2H-isoindole-1-carboxylates

A general protocol for the synthesis of substituted 5-aminotetrazoles by reacting cyanogen azide with the primary allyl amines afforded either by SN2 or SN2′- reaction of Morita- Baylis-Hillman acetate of acrylate has been ...

To fold or not to fold?: That the conformational preferences of foldamer backbones might be modulated by appended sugars and also that such effects might inform on the roles of glycans on the preferred secondary structures ...