Medicinal and Process Chemistry: Recent submissions

Now showing items 61-80 of 531

Synthesis and Biotinylation of Oligosaccharide Fragments of Mannosylated and 5-Deoxy-5-methylthio-xylofuranosylated Lipoarabinomannan from Mycobacterium tuberculosis

Mandal, P K; Chheda, P R (2015)

The attachment of biotin to a molecule provides a powerful tool in biology. Here, we report an efficient synthesis and biotinylation of mannosylated and 5-deoxy-5-methylthio-xylofuranosylated Lipoarabinomannan from ...
Facile Synthesis of 11-aryl-6H-isoindolo [2,1-a]indol-6-ones via Hypervalent Iodine (III)-Promoted Cascade Cyclization

Dev, Kapil; Maurya, Rakesh (2015)

An efficient method was developed for the synthesis of tetracyclic fused indoleandisoindoline ring system, under metal-free conditions. The hypervalent iodine PIDA-mediated regioselective as well as chemoselective ...
Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity

Reddy, P V; Saquib, Mohammad; Mishra, N N; Shukla, P K; Shaw, A K (2014)

The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various ‘in house’ synthesized sugar derived ...
Efficient Stereocontrolled Synthesis of Sitagliptin Phosphate

Subbaiah, C S; Haq, W (2014)

Synthesis of sitagliptin phosphate 1, a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from chiral synthon (1,4-bis[(R)-1-phenylethyl]piperazine-2,5-dione) 2, involving ...
New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents

Chauhan, Kuldeep; Sharma, Moni; Trivedi, Priyanka; Chaturvedi, Vinita; Chauhan, P. M. S. (2014)

In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, ...
Design, Synthesis and Biological evaluation of Bicyclic Iminosugar Hybrids: Conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors

Arora, Inderpreet; Kashyap, V K; Singh, A K; Dasgupta, Arunava; Kumar, Brijesh; Shaw, A K (2014)

Principle guided design of glycan processing enzyme inhibitors involves embedding aromatic group onto charge and shape mimics. Intramolecular azide-alkyne cycloaddition was used as a simple and versatile strategy for the ...
Amino Acid and Water-Driven Tunable Green Protocol to Access S-S/C-S Bonds via Aerobic Oxidative Coupling and Hydrothiolation

Shard, Amit; Kumar, Rajesh; Saima; Sharma, Nidhi; Sinha, A K (2014)

A green methodology utilizing natural auxiliary like L-Arginine in conjunction with water and oxygen led to oxidative coupling of thiols into disulfides (S-S bond) whereas thiol-yne coupling (TYC) to access vinyl sulfides ...
Applications of allylamines for the syntheses of aza-heterocycles§

Nag, Somnath; Batra, Sanjay (2011)

Allylamine is one of the most fundamental units in organic chemistry which has been engineered to afford a diverse range of complex structural frameworks. This review encompasses the literature from 2006 to May 2010 ...
Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents

Sharma, Smriti; Saquib, Mohammad; Verma, Saroj; Mishra, N N; Shukla, P K; Srivastava, Ranjana; Prabhakar, Y S; Shaw, A K (2014)

Here, we describe a molecular hybridization inspired design and synthesis of novel 6-triazolyl 2,3,6-trideoxy sugars as promising new broad-spectrum antimicrobial agents using click chemistry in key step. These compounds ...
Amino Acids Chirons: A Tool for Asymmetric synthesis of Heterocycles

Singh, Priyanka; Samanta, Krishnananda; Das, S K; Panda, Gautam (2014)

Amino acids as chiral pool have been extensively used by synthetic organic and medicinal chemists for access to heterocycles (monocycles, bicycles or polycycles either bridged or fused) owing to their easy availability in ...
Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water

Pandey, A K; Sharma, Rashmi; Singh, Awantika; Shukla, Sanjeev; Srivastava, Kumkum; Puri, S K; Kumar, Brijesh; Chauhan, P M S (2014)

An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in aqueous reaction medium has been developed. The protocol is successfully ...
Discovery of 17 Gliptins in 17-Years of Research for the Treatment of Type 2 Diabetes: A Synthetic Overview

Kushwaha, R N; Haq, W; Katti, S B (2014)

Gliptins, commonly known as clinical DPP-IV inhibitors have become a new class of potential drug candidate and are being hoped as a permanent eraser for type 2 diabetes. Therefore, gliptins have been a centre of research ...
Synthetic Methodologies of Achiral Diarylmethanols, Diaryl and Triarylmethanes (TRAMs) and Medicinal Properties of Diaryl and Triarylmethanes-An Overview

Mondal, Sankalan; Panda, Gautam (2014)

The last decade has witnessed a high demand of various synthetic approaches towards bioactive achiral diarylmethanols, diaryl and triarylmethanes and the molecules derived thereof. Their biological and therapeutical relevancy ...
Base mediated 7-exo-dig intramolecular cyclization of Ugi-Propargyl precursors: Ugi-Propargyl precursors and regioselective synthetic approach toward diverse 1, 4-benzoxazepine-5(2H)-ones

Pandey, Shashi; Kumar, S V; Kant, Ruchir; Chauhan, P M S (2014)

A metal-free facile and efficient two-step synthetic protocol for the preparation of 1, 4-benzoxazepine-5(2H)-ones derivatives has been developed. The protocol involves Ugi reaction followed by K2CO3 mediated highly ...
Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds

Khan, Shahnawaz; Tyagi, Vikas; Mahar, Rohit; Bajpai, Vikas; Kumar, Brijesh; Chauhan, P M S (2013)

The dimethylamino functionality is generally introduced onto the 3,5-dihydro-4H-imidazol-4-one skeleton by treatment of a halogenated derivative with low-boiling dimethylamine at a high temperature and pressure. The ...
Ugi Four-Component Reaction with Tandem Deprotection, Cyclization and Pictet–Spengler Reaction: A Concise Route to N-Fused Polycyclic Indolediketopiperazine Alkaloid Analogues

Tyagi, Vikas; Khan, Shahnawaz; Chauhan, P M S (2013)

Aza-fused polycyclic indolediketopiperazine alkaloids are of potential interest due to their broad range of biological activities. Traditionally, a number of methods have been reported to generate N-fused polycyclic ...
Synthesis of 3-Carbonyl Pyrazole-5-Phosphonates via 1,3-Dipolar Cycloaddition of Bestman-Ohira Reagent with Ynones

Pramanik, M M D; Kant, Ruchir; Rastogi, Namrata (2014)

The present work explores the hitherto unexplored reactivity of ynones as dipolarophiles with Bestman Ohira reagent. The reaction offers a convenient route for the synthesis of regioisomerically pure 3,5-disubstituted or ...
1-Formyl-9H-β-Carboline: A Useful Scaffold for Synthesizing Substituted- and Fused β-Carbolines

Singh, Virender; Batra, Sanjay (2012)

β-Carboline represents the core unit of several alkaloids and bioactive agents. This review assimilates the reports pertaining to the synthetic applications of 1-formyl-9H-β-carbolines for the synthesis of substituted and ...
Synthesis and Identification of Chiral Aminomethylpiperidine Carboxamides as Inhibitor of Collagen Induced Platelet Activation

Kumar K S, Anil; Misra, Ankita; Siddiqi, T I; Srivastava, Stuti; Jain, Manish; Bhatta, R S; Barthwal, M K; Dikshit, Madhu; Dikshit, D K (2014)

A series of chiral lactamcarboxamides of aminomethylpiperidine were synthesized and investigated for the collagen induced in vitro anti-platelet efficacy and collagen plus epinephrine induced in vivo pulmonary thromboembolism. ...
Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents

Gupta, Shweta; Shivahare, Rahul; Korthikunta, Venkateswarlu; Singh, Rohit; Gupta, Suman; Tadigoppula, Narender (2014)

Antileishmanial activities of thirty five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 µM) against ...

Now showing items 61-80 of 531

Search DSpace

Advanced Search

Browse

All of DSpace
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

Medicinal and Process Chemistry: Recent submissions

Search DSpace

Browse

All of DSpace

This Collection

My Account