Abstract:
Anovel palladium-catalyzed approach to 2-benzofuranyl/indolylacetamides from 1-(o-hydroxy/aminophenyl)propargylic alcohols and isocyanides is described. The reaction proceeds through a cascade that includes oxy/amino-palladation, isocyanide insertion and 1,4-hydroxyl migration. No oxidant or ligand is needed to promote the cascade and the reactions are carried out in mild conditions to afford the products through high functional tolerance.
