Browsing Pharmacokinetics & Metabolism by Title

Now showing items 1-20 of 40

Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application

Chhonker, Y S; Prasad, Y D; Chandasana, Hardik; Vishvkarma, Akhilesh; Mitra, Kalyan; Shukla, P K; Bhatta, R S (2015)

Fungal keratitis is the major cause of vision loss worldwide. Amphotericin-B is considered as the drug of choice for fungal infections. However, its use in ophthalmic drug delivery is limited by the low precorneal residence ...
Bioanalysis of antimalarials using liquid chromatography

Wahajuddin; Raju, K S R; Taneja, Isha (2013)

Among the most central aspects of the drug-development process is estimation of drug levels in biological systems, which is an integral part of preclinical and clinical studies. Once the drug is marketed, determination of ...
Bioanalytical Method Development and Validation for Simultaneous Estimation of (R) - and (S) - Isomer of S002-333: a potent Novel Anti-Thrombotic Agent using LC-MS/MS

Bhatta, R S; Chhonker, Y S; Kumar, D; Saxena, A K; Jain, G K (2011)

A selective, sensitive and high throughput liquid chromatography–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the chromatographic separation and quantitation of diastereomers of S002-333, ...
Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies.

Bhatta, R S; Chandasanab, H; Rathi, C; Kumar, D; Chhonker, Y S; Jain, G K (2010)

A new selective and sensitive high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of natamycin in rabbit tears using amphotericin B as internal ...
Determination of 3-Hydroxy pterocarpan, a novel osteogenic compound in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study

Manickavasagama, Lakshmi; Gupta, Sonal; Mishra, Smriti; Kumar, A; Raghuvanshi, Ashutosh; Goel, Atul; Singh, Divya; Jain, G K (2011)

A rapid, sensitive and selective LC-MS/MS method for the quantitative analysis of 3-hydroxy pterocarpan (S006-1709) in female rat plasma has been developed and validated. Discovery RP18 column was used for the chromatographic ...
Development and validation of a Liquid Chromatography–mass Spectrometry Method for Determination of Amphotericin B in Rabbit Tears and its Application to Ocular Pharmacokinetic Study

Bhatta, R S; Rathi, Chetan; Chandasana, Hardik; Kumar, Devendra; Chhonker, Y S; Jain, G K (2011)

A rapid and sensitive LC-MS-MS method was developed for the quantiﬁcation of amphotericin B in rabbit tears using natamycin as internal standard. The analyte and internal standard were extracted from the tear sample using ...
Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems

Wahajuddin; Taneja, Isha; Arora, Sumit; Raju, K S R; Siddiqui, Nida (2013)

Dietary isoflavones, popularly known as phytoestrogens, represent one of the most biologically active classes of flavonoids. Numerous in vitroandin vivostudies provide convincing evidence regarding their beneficial effects ...
Do Blood Sampling Sites Affect Pharmacokinetics?

Rangaraj, Nagarjun; Vaghasiya, Kalpesh; Jaiswal, Swati; Sharma, Abhisheak; Shukla, Mahendra; Lal, Jawahar (2014)

Preclinical and clinical pharmacokinetic (PK) profiling is the bottleneck of the drug development process. PK involves assessment of plasma/serum/blood drug concentration at different time points post drug administration. ...
Dose escalation pharmacokinetic and lipid lowering activity of a novel FXR modulator: 16-Dehydropregnenalone

Kumar, D; Khanna, A K; Pratap, R; Sexana, J K; Bhatta, R S (2012)

The dose escalation pharmacokinetic of 16-Dehydropregnenalone and its major metabolite 5-pregnene-3β-ol-16,17-epoxy-20-one (M1) by intravenous and oral administration were studied in SD rats. Plasma concentration profile ...
Dried Blood Spots in Bioanalysis of Antimalarials: Relevance and Challenges in Quantitative Assessment of Antimalarial Drugs

Taneja, Isha; Erukala, Madhuri; Raju, K S R; Singh, S P; Wahajuddin (2013)

Malaria is the leading parasitic disease in the emerging countries. Therapeutic drug monitoring of antimalarial drugs is becoming increasingly important due to their spreading resistance. Measuring systemic antimalarial ...
Erythrocytes based synthetic delivery systems: transition from conventional to novel engineering strategies

Bhateria, Manisha; Rachumallu, Ramakrishna; Singh, Rajbir; Bhatta, R S (2014)

Introduction: Erythrocytes (RBCs) and artificial/synthetic delivery systems such as liposomes, nanoparticles (NPs) are the most investigated carrier systems. Herein, progress made from conventional approach of using RBC ...
Evaluation of memory enhancing clinically available standardized extract of Bacopa monniera on P-glycoprotein and Cytochrome P450 3A in Sprague-Dawley rats

Singh, Rajbir; Jagadeesh, Panduri; Kumar, Devendra; Kumar, Deepak; Chandsana, Hardik; Ramakrishna, Rachumallu; Bhatta, R S (2013)

Bacopa monniera is a traditional Ayurvedic herbal medicine used to treat various mental ailments from ancient times. Recently, chemically standardized alcoholic extract of Bacopa monniera (BM) has been developed and currently ...
Gender Differences in Pharmacokinetics of lumefantrine and its metabolite desbutyl-lumefantrine in Rats

Wahajuddin; Singh, S P; Jain, G K (2012)

Lumefantrine has been reported to be mainly bio-transformed by cytochrome P450 isozyme 3A4 in to desbutyl-lumefantrine (DLF) in human liver microsomes. Since, CYP3A is expressed in a sex specific manner in rats, it could ...
High-throughput Quantification of isoflavones, Biochanin A and Genistein, and their conjugates in female rat plasma using LC-ESI-MS/MS: application in pharmacokinetic study

Singh, S P; Wahajuddin; Ali, M M; Jain, G K (2009)

Isoflavones containing foods and dietary supplements are widely consumed for putative health benefits (e.g., cancer chemoprevention, beneficial effects on serum lipids associated with cardiovascular health, reduction of ...
In vitro Absorption Studies of A New Antimalarial in the Gastro, International Tract

Jain, G K; Singh, S (1990)

N'-(3'-Acetyl-4',5'-dihydro-2' - furanyl)-N4-(6-metlaoxy-8 - quinolinyl) - 1,4-pentane diamine 1, a new anti-relapse antimalarial primaquine derivative develop. ed at C.D.R.I. (compound No.80/53) is less toxic than the ...
In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes

Singh, Rajbir; Ramakrishna, Rachumallu; Bhateria, Manisha; Bhatta, R S (2014)

Bacopa monniera (BM) is a traditional Ayurvedic medicinal plant that has been used worldwide for its nootropic action. Chemically standardized extract of BM is now available as over the counter herbal remedy to enhance ...
Insights into the Pharmacokinetic Properties of Antitubercular Drugs

Shukla, Mahendra; Sharma, Abhisheak; Jaiswal, Swati; Lal, Jawahar (2016)

Introduction: The furiously advancing cases of multidrug-resistant tuberculosis (TB) along with the recent emergence of total drug resistant TB and TB-AIDS comorbidity prompt an increasingly solemn threat to global public ...
Intravenous Pharmacokinetics and Oral Bioavailability of Biochanin A in Female Rats

Singh, S P; Wahajuddin; Jain, G K (2011)

Biochanin A (BCA) is a methoxylated isoflavone which is the major constituent in red clover and in commercially available extracts of this plant. The objective of the present study was to evaluate the bioavailability and ...
Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats

Wahajuddin; Singh, S P; Kanumuri, S R R; Nafis, Asad; Puri, S K; Jain, G K (2011)

Background Despite the wide spread use of lumefantrine, there is no study reporting the detailed preclinical pharmacokinetics of lumefantrine. For the development of newer anti-malarial combination(s) and selection of ...
LC-MS/MS assay for quantification of a novel Antitubercular molecule S006-830: Pharmacokinetic and plasma protein binding studies in Rats

Hidau, Mahendra Kumar; Singh, Yeshwant; Shahi, Sudhir; Mounika, Poojari; Singh, Shio Kumar (2015)

A highly sensitive and selective LC-MS/MS assay was developed and validated for determination of a novel antitubercular compound S006-830 in rat plasma. The analyte and internal standard (IS) were extracted from plasma by ...

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