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Now showing items 1-20 of 40

In vitro Absorption Studies of A New Antimalarial in the Gastro, International Tract

Jain, G K; Singh, S (1990)

N'-(3'-Acetyl-4',5'-dihydro-2' - furanyl)-N4-(6-metlaoxy-8 - quinolinyl) - 1,4-pentane diamine 1, a new anti-relapse antimalarial primaquine derivative develop. ed at C.D.R.I. (compound No.80/53) is less toxic than the ...
High-throughput Quantification of isoflavones, Biochanin A and Genistein, and their conjugates in female rat plasma using LC-ESI-MS/MS: application in pharmacokinetic study

Singh, S P; Wahajuddin; Ali, M M; Jain, G K (2009)

Isoflavones containing foods and dietary supplements are widely consumed for putative health benefits (e.g., cancer chemoprevention, beneficial effects on serum lipids associated with cardiovascular health, reduction of ...
Pharmacokinetics of the Proton Pump Inhibitor CDRI-85/92 and its Ester Prodrug, A New H+/K+-ATPase Inhibitor with Anti-ulcer Activities, after Oral Doses in Rats

Lal, Jawahar; Pandey, S K; Dikshit, D K; Gupta, R C (2009)

5-Styryl-4, 5-cis-1, 3-oxazole-2-one-4-carboxylic acid (CDRI-85/92) is a new proton pump inhibitor presently in advanced stage of preclinical trials as antiulcer pharmacophore. Since proton pump inhibitors are prodrugs ...
LC-MS/MS METHOD FOR SIMULTANEOUS ANALYSIS OF CLADRIN AND EQUOL IN RAT PLASMA AND ITS APPLICATION IN PHARMACOKINETICS STUDY OF CLADRIN

Lakshmi, Manickavasagam; Gupta, Sonal; Mishra, Smriti; Rakesh, Maurya; Naibedya, Chattopadhyay; Jain, G K (2010)

A rapid and selective LC-MS/MS method for simultaneous analysis of cladrin and equol in female rat plasma has been developed and validated. The chromatographic separation was carried out on RP18 column and MS/MS analysis ...
Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies.

Bhatta, R S; Chandasanab, H; Rathi, C; Kumar, D; Chhonker, Y S; Jain, G K (2010)

A new selective and sensitive high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of natamycin in rabbit tears using amphotericin B as internal ...
Liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of 97/78 and its in-vivo metabolite 97/63, a novel trioxane antimalarial in human plasma and its application to protein binding study

Kushwaha, H N; Gautam, Nagsen; Singh, S K (2010)

A sensitive, selective and specific LC-MS/MS assay for simultaneous quantification of 97/78 and its active in-vivo metabolite 97/63, a novel 1,2,4-trioxane antimalarial in human plasma has been developed and validated using ...
Bioanalytical Method Development and Validation for Simultaneous Estimation of (R) - and (S) - Isomer of S002-333: a potent Novel Anti-Thrombotic Agent using LC-MS/MS

Bhatta, R S; Chhonker, Y S; Kumar, D; Saxena, A K; Jain, G K (2011)

A selective, sensitive and high throughput liquid chromatography–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the chromatographic separation and quantitation of diastereomers of S002-333, ...
Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats

Wahajuddin; Singh, S P; Kanumuri, S R R; Nafis, Asad; Puri, S K; Jain, G K (2011)

Background Despite the wide spread use of lumefantrine, there is no study reporting the detailed preclinical pharmacokinetics of lumefantrine. For the development of newer anti-malarial combination(s) and selection of ...
Determination of 3-Hydroxy pterocarpan, a novel osteogenic compound in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study

Manickavasagama, Lakshmi; Gupta, Sonal; Mishra, Smriti; Kumar, A; Raghuvanshi, Ashutosh; Goel, Atul; Singh, Divya; Jain, G K (2011)

A rapid, sensitive and selective LC-MS/MS method for the quantitative analysis of 3-hydroxy pterocarpan (S006-1709) in female rat plasma has been developed and validated. Discovery RP18 column was used for the chromatographic ...
Liquid chromatography–mass spectrometry method for determination of amphotericin B in rabbit tears and its application to ocular pharmacokinetic study

Bhatta, R S; Rathi, C; Chandasana, H; Kumar, D; Chhonker, Y S; Jain, G K (2011)

A rapid and sensitive LC/MS/MS method was developed for the quantiﬁcation of amphotericin B in rabbit tears using natamycin as internal standard. The analyte and internal standard were extracted from tear sample by solid ...
PAMPA permeability, plasma protein binding, blood Partition, pharmacokinetics and metabolism of formononetin, a methoxylated isoflavone

Singh, S P; Wahajuddin; Tewari, Divyesh; Pradhan, Tejaswini; Jain, G K (2011)

Formononetin (FMN) is a methoxylated isoflavone which is the major constituent in red clover and in commercially available extracts of this plant. In this study, we investigated the parallal artificial membrane permeability ...
Liquid chromatography–mass spectrometry method for the quantification of tamoxifen and its metabolite 4-hydroxytamoxifen in rat plasma: Application to interaction study with biochanin A (an isoflavone)

Singh, S P; Wahajuddin; Ali, M M; Kohli, Kanchan; Jain, G K (2011)

Tamoxifen is the agent of choice for the treatment of estrogen receptor-positive breast cancer. Tamoxifen is a substrate of P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A, and biochanin A (BCA) is an inhibitor ...
Intravenous Pharmacokinetics and Oral Bioavailability of Biochanin A in Female Rats

Singh, S P; Wahajuddin; Jain, G K (2011)

Biochanin A (BCA) is a methoxylated isoflavone which is the major constituent in red clover and in commercially available extracts of this plant. The objective of the present study was to evaluate the bioavailability and ...
Simultaneous estimation of E- and Z- isomers of guggulsterone in rabbit plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study

Bhatta, R S; Chhonker, Y S; Jain, G K (2011)

A sensitive and selective liquid chromatography / tandem mass spectrometric method was developed for simultaneous determination of E- and Z-guggulsterone isomers (antihyperlipidemic drug) in rabbit plasma. Both the isomers ...
Development and validation of a Liquid Chromatography–mass Spectrometry Method for Determination of Amphotericin B in Rabbit Tears and its Application to Ocular Pharmacokinetic Study

Bhatta, R S; Rathi, Chetan; Chandasana, Hardik; Kumar, Devendra; Chhonker, Y S; Jain, G K (2011)

A rapid and sensitive LC-MS-MS method was developed for the quantiﬁcation of amphotericin B in rabbit tears using natamycin as internal standard. The analyte and internal standard were extracted from the tear sample using ...
Simultaneous Determination of Nine Model Compounds in Permeability Samples using RP-HPLC: Application to Prove the Cassette Administration Principle in Single Pass Intestinal Perfusion Study in Rats

Wahajuddin; Singh, S P; Raju, K S R; Nafis, Asad; Jain, G K (2012)

A simple, sensitive and specific reversed phase high performance liquid chromatographic (RP-HPLC) method for simultaneous determination of atenolol, paracetamol, hydrochlorothiazide, caffeine, cephalexin, metoprolol, ...
Dose escalation pharmacokinetic and lipid lowering activity of a novel FXR modulator: 16-Dehydropregnenalone

Kumar, D; Khanna, A K; Pratap, R; Sexana, J K; Bhatta, R S (2012)

The dose escalation pharmacokinetic of 16-Dehydropregnenalone and its major metabolite 5-pregnene-3β-ol-16,17-epoxy-20-one (M1) by intravenous and oral administration were studied in SD rats. Plasma concentration profile ...
Gender Differences in Pharmacokinetics of lumefantrine and its metabolite desbutyl-lumefantrine in Rats

Wahajuddin; Singh, S P; Jain, G K (2012)

Lumefantrine has been reported to be mainly bio-transformed by cytochrome P450 isozyme 3A4 in to desbutyl-lumefantrine (DLF) in human liver microsomes. Since, CYP3A is expressed in a sex specific manner in rats, it could ...
Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: in-vitro and pharmacokinetics studies

Bhatta, R S; Chandasana, H; Chhonker, Y S; Rathi, C; Kumar, D; Mitra, K; Shukla, P K (2012)

The aim of this study was to prepare natamycin encapsulated lecithin/chitosan mucoadhesive nanoparticle (NPs) for prolonged ocular application. These NPs were characterized by their mean particle size 213 nm, encapsulation ...
Bioanalysis of antimalarials using liquid chromatography

Wahajuddin; Raju, K S R; Taneja, Isha (2013)

Among the most central aspects of the drug-development process is estimation of drug levels in biological systems, which is an integral part of preclinical and clinical studies. Once the drug is marketed, determination of ...

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