Abstract:
N'-(3'-Acetyl-4',5'-dihydro-2' - furanyl)-N4-(6-metlaoxy-8 - quinolinyl) - 1,4-pentane diamine 1, a new anti-relapse antimalarial primaquine derivative develop. ed at C.D.R.I. (compound No.80/53) is less toxic than the parent compound. Its in vitro diffusion and absorptiin rate constants in simulated body fluids have been determined using Sartorius Absorptiion Simulator.
