Medicinal and Process Chemistry: Recent submissions

Now showing items 481-500 of 531

A Combinatorial Approach to the Variable Selection in Multiple Linear Regression: Analysis of Selwood et al Data set -A Case Study.

Prabhakar, Yenamandra S (2003)

A combinatorial protocol (CP) is introduced here to interface it with the multiple linear regression (MLR) for variable selection. The efficiency of CP-MLR is primarily based on the restriction of entry of correlated ...
Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents

Batra, Sanjay; Srinivasan, T; Rastogi, S K; Kundu, Bijoy; Patra, A; Bhaduri, A P; Dikshit, Madhu (2002)

The 3-substitutedphenyl-5-isoxazolecarboxaldehydes have been identified as activated aldehydes for the generation of isoxazole-based combinatorial libraries on solid phase through automation. Three highly functionalized ...
A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines

Batra, Sanjay; Srivastava, Pratima; Roy, Kamal; Pandey, V C; Bhaduri, A P (2000)

1-[(3’-Diethylaminopropyl)-3-(substitutedphenylmethylene) pyrrolidines] were synthe-sized and evaluated for CQ resistant reversal activity. The compounds of the series elicit better biological response than their phenyl ...
Synthesis, Optical Resolution, and Configurational Assignment of Novel Axially Chiral Quateraryls

Goel, Atul; Singh, Fateh V; Kumar, Vijay; Reichert,Matthias; Gulder, Tobias A M; Bringmann, Gerhard (2007)

A one-pot, general synthesis of highly functionalized quateraryls through carbanion-induced, base-catalyzed ring transformation of 5,6-diaryl-2H-pyran-2-ones and core-substituted phenylacetones is delineated. These conversions ...
Regioselective Synthesis of Functionally Crowded Benzenes at Room Temperature through Ring Transformation of 2H-Pyran-2-ones

Singh, Fateh V; Kumar, Vijay; Goel, Atul (2007)

An expeditious synthesis of highly substituted benzenes with electron withdrawing or donating substituents is described and illustrated by carbanion-induced ring transformation of 2H-pyran-2-one with malononitrile in ...
Application of primary allyl amines afforded by the Baylis-Hillman adducts for heterocyclic synthesis: Generation of 5-benzyl-4(3H)-pyrimidinones and 2-benzylidene-2,3-dihydro-pyrrolizin-1-ones

Nag, Somnath; Madapa, Sudharshan; Batra, Sanjay (2008)

The applications of the primary allyl amines afforded by the acetyl derivative of Baylis-Hillman adducts of acrylate for the synthesis of heterocycles using robust reactions are described. In the first strategy a one-pot ...
Significant yield improvement in the stereoselective synthesis of allyl cyanides from Baylis-Hillman derivatives in aqueous medium under the influence of the Phase-Transfer catalyst

Singh, Vijay; Pathak, Richa; Batra, Sanjay (2007)

The nucleophilic reaction of NaCN with the acetyl derivative of Baylis-Hillman adducts in the presence of a phase-transfer catalyst in aqueous medium stereoselectively affords the corresponding allyl cyanides in a short ...
A Facile synthesis of 3-Methylene-4-aryl-1,3,4,5-tetrahydro-benzo[b][1,4] di-azepin-2-ones and 3-arylemethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines

Pathak, Richa; Nag, Somnath; Batra, Sanjay (2006)

A simple and convenient synthesis of 3-methylene-4-aryl-1,3,4,5-tetrahydro-benzo[b][1,4] diazepin-2-ones was accomplished by the SN2 nucleophilic substitution of the acetates of Baylis-Hillman adducts of acrylate with ...
Medicinal Chemistry of ureido derivatives as Antiinfectives

Batra, Sanjay; Tusi, Zehra; Madapa, Sudharshan (2006)

Ureides are compounds, which essentially incorporate urea as a substructural component either in open or cyclic form. Ureido derivatives are one of the oldest classes of bioactives, widely used as antiinfective agents. ...
Mild and efficient hydrolysis of thioglycosides to glycosyl hemiacetals using N-iodosaccharin

Mandal, P K; Misra, A K (2007)

A convenient methodology has been developed for the mild hydrolysis of thioglycosides to the corresponding hemiacetals using N-iodosaccharin without any requirement of co-activator. Most of the functional groups used for ...
Synthesis of oligosaccharides corresponding to the polysaccharides of Lactobacillus and Thermophlilus strains

Mandal, P K; Misra, A K (2007)

Synthesis of a branched trisaccharide and a tetrasaccharide repeating units corresponding to the polysaccharides of Lactobacillus spp. G-77 and Thermus thermophilus Samu-SA1 as their methyl glycosides has been achieved in ...
Aza-Michael addition of amines to activated alkenes catalyzed by Silica supported perchloric acid under a solvent-free condition

Mukherjee, Chinmoy; Misra, Anup Kumar (2007)

An efficient aza-Michael addition of amines to a series of ,-unsaturated ketones, carboxylic esters, nitriles and chalcones has been carried out using perchloric acid supported over silica gel (HClO4-SiO2) at room ...
Efficient Synthesis of Glycosyl Enaminoesters Directly from Glycosyl Azides

Kumar, Rishi; Maulik, P R; Misra, A K (2007)

A convenient methodology has been developed for the synthesis of glycosylenaminoesters directly from glycosyl azides under hydrogenetion condition. Yields were moderate to good in all cases.
Concise synthesis of two trisaccharide analogs related to the glycone constituent of Phanoside, a novel insulin releasing natural product

Agnihotri, Geetanjali; Mandal, P K; Misra, A K (2007)

Two trisaccharides (2 and 3) related to related to the glycone part of Phanoside, an insulin release stimulator have been synthesized in excellent yield.
Glycosylation and pyranose-furanose isomerization of carbohydrates using HClO4-SiO2: Synthesis of oligosaccharides containing galactofuranose

Mukherjee, Chinmoy; Misra, Anup Kumar (2007)

A series of di- and trisaccharides containing galactofuranose were synthesized using HClO4-SiO2 catalyzed glycosylation and ring transformation for the conversion of galactopyranose to galactofuranose. Yields in glycosylations ...
Synthesis of a pentasaccharide repeating unit of the extracellular polysaccharide produced by lactobacillus delbrueckii subsp. Bulgaricus 291

Tiwari, Pallavi; Misra, Anup Kumar (2007)

A pentasaccharide as its methyl glycoside has been synthesized efficiently using a modified glycosylation strategy. This pentasaccharide is a repeating unit of the exopolysaccharides produced by Lactobacillus delbrueckii ...
Odorless Preparation Of Thioglycosides And Thio Michael Adducts Of Carbohydrate Derivatives

Mukherjee, Chinmoy; Misra, Anup Kumar (2007)

A generalized, odorless, one-pot methodology has been developed for the preparation of 1,2-trans-thioglycosides and thio-Michael addition products of carbohydrate derivatives through triphenyl phosphine mediated cleavage ...
An efficient substituent dependent synthesis of congested pyridines and pyrimidines

Pratap, Ramendra; Kumar, Brijesh; Ram, Vishnu Ji (2007)

An efficient and versatile synthesis of various congested pyridines 3a-h, 6a,b, 8a-n, lOa-g, and 16a,b, and (pyrimidin-4-yl)acetonitriles 13a-g has been delineated by base catalyzed ring transformation of suitably ...
Synthesis of arylated highly congested indans using a domino sequence

Pratap, Ramendra; Kumar, Brijesh; Ram, Vishnu Ji (2007)

A novel and efficient regioselective synthesis of various arylated highly congested 7-aryl-5-methylsulfanylindan-4-carbonitriles (3a-(), methyl 7-aryl-5-methylsulfanylindan-4-carboxylates (lOa-e) and 7-aryl-5-methylsulf ...
An elegant and unprecedented approach to 2-methylbenzofurans

Yadav, A K; Singh, B K; Singh, Nimisha; Tripathi, R P (2007)

An effective route for the synthesis of a variety of 2-methylbenzofurans is reported via DBU catalyzed dehydroiodination of easily accessible 2-iodomethyl-2,3-dihydrobenzofurans. The latter could be easily obtained by ...

Now showing items 481-500 of 531

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