Medicinal and Process Chemistry: Recent submissions

Now showing items 501-520 of 531

Tributyltin hydride-mediated straightforward synthesis of a new isoxazolo-benzazulene ring system

Singh, Vijay; Batra, Sanjay (2006)

Tributyltin hydride-mediated straightforward synthesis of a new isoxazolo-benzazulene system from the derivatives afforded by the Baylis-Hillman reaction of 3-(2-bromophenyl)-4-isoxazolecarbaldehydes is described
An alternate approach to quinoline architecture via Baylis-Hillman chemistry: SnCl2-mediated tandem reaction toward synthesis of 4-(substituted vinyl)-quinolines

Madapa, Sudharshan; Singh, Virender; Batra, Sanjay (2006)

An alternate approach to densely substituted quinolines from the products of SN2 nucleophilic substitution reaction between the acetyl derivatives of the Baylis-Hillman adducts obtained from 2-nitrobenzaldehydes and the ...
Studies toward the construction of substituted piperidine-2-ones and pyridine-2-ones from Baylis-Hillman adducts: Discovery of a facile synthesis of 5-methyl-4-oxo-6-aryl-3-aza-bicyclo[3.1.0]hexane-1-carboxylates

Singh, Vijay; Yadav, G P; Maulik, P R; Batra, Sanjay (2006)

Studies toward the construction of functionalised piperidone derivatives from derivatives of Baylis-Hillman adducts are described. Interestingly the 6-oxo-4-aryl-piperidine-3-carboxylates generated during the study serve ...
Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives

Nag, Somnath; Pathak, Richa; Kumar, Manish; Shukla, P K; Batra, Sanjay (2006)

The synthesis of several 1-(2-cyano-3-aryl-allyl)-3-aryl-urea(thiourea) constructed from the reaction between allyl amines generated from Baylis-Hillman acetates and substituted isocyanates and isothiocyanates has been ...
Studies on the reduction of the nitro group in 3-aryl-2-methylene-4-nitro-alkanoates afforded by the Baylis-Hillman adducts: Synthesis of 4-aryl-3-methylene-2-pyrrolidinones and 3-(1-alkoxycarbonyl-vinyl)-1H-indole-2-carboxylates

Singh, Vijay; Kanojiya, Sanjeev; Batra, Sanjay (2006)

The formation of substituted 2-pyrrolidinones and indoles by the reduction of the secondary nitro group in appropriate 3-aryl-2-methylene-4-nitroalkanoates afforded by Baylis-Hillman chemistry via different reducing agents ...
A reinvestigation into the reaction of NH4OAc with acetyl derivatives of Bay-lis-Hillman adducts: Formation of tertiary and secondary allyl amines in-stead of primary allyl amines

Singh, Vijay; Pathak, Richa; Kanojiya, Sanjeev; Batra, Sanjay (2005)

A reinvestigation into the reaction between ammonium acetate and the acetyl derivatives of Baylis-Hillman adducts has led us to conclude that the products obtained are tertiary and secondary allyl amines and not the primary ...
Alternate, Easy and practical synthesis of allyl amines from acetyl derivatives of Baylis-Hillman adducts using Methanolic Ammonia

Pathak, Richa; Singh, Vijay; Nag, Somnath; Kanojiya, Sanjeev; Batra, Sanjay (2006)

A methanolic ammonia-mediated alternate, easy and practical stereoselective synthesis of allyl amines from the acetyl derivatives of Baylis-Hillman adducts is described.
Simple and efficient synthesis of substituted 2-pyrrolidinones, 2-pyrrolones and pyrrolidines from enaminones of Baylis-Hillman derivatives of 3-isoxazolecarbaldehydes

Singh, Vijay; Saxena, Rashmi; Batra, Sanjay (2005)

The enaminones, generated from derivatives of appropriately substituted Baylis-Hillman adducts of 3-isoxazolecarbaldehydes undergo intramolecular ring-closure reactions to afford substituted 2-pyrrolidinones, 1,5-dihydro ...
A facile route to the synthesis of novel 2-amino-1,4,5,6-tetrahydropyrimidines from Baylis-Hillman products of acrylonitrile

Pathak, Richa; Roy, Amrendra K; Batra, Sanjay (2005)

A facile route for the synthesis of novel 5-substituted-2-amino-1,4,5,6-tetrahydro pyrimidines from the Baylis-Hillman adducts obtained from reaction of aldehydes and acrylonitrile is described.
Neighboring group effect: DBU-promoted ring transformation of substituted isoxazoles to substituted pyrroles

Roy, A K; Pathak, Richa; Yadav, G P; Maulik, P R; Batra, Sanjay (2006)

A novel DBU-promoted ring transformation of substituted isoxazoles to substituted pyrroles is described
Studies on the catalytic hydrogenation of Baylis Hillman derivatives of substituted isoxazolecarbaldehydes

Saxena, Rashmi; Singh, Vijay; Batra, Sanjay (2004)

Results of the catalytic hydrogenation of Baylis-Hillman adducts obtained from substituted 3-, 4- and 5-isoxazolecarbox-aldehydes and their corresponding acetates in the presence of Raney-Ni and Pd-C are presented. The ...
Baylis-Hillman reaction assisted synthesis of substituted 5,8-dihydro-isoxazolo[4,5-c]azepin-4-one: A novel isoxazole-annulated heterocycle

Batra, Sanjay; Roy, Amrendra K (2004)

The novel synthesis of a new isoxazole-annulated heterocycle namely 5,8-dihydro-isoxazolo[4,5-c]azepin-4-one described herein is based on the reaction of benzyl amine with acetates of Baylis-Hillman adducts generated from ...
Interesting results of catalytic hydrogenation of 3-(2-nitrophenyl)-isoxazoles and 3-(nitro-substituted-phenyl)-2-isoxazolines

Singh, Vijay; Madapa, Sudharshan; Yadav, G P; Maulik, P R; Batra, Sanjay (2006)

The Pd-C-assisted hydrogenolysis of substituted 3-(2-nitrophenyl)-isoxazoles, irrespective of substitution on the isoxa-zole ring, invariably leads to reduction of nitro to amino group with concomitant regiospecific ring ...
A general approach to the synthesis of substituted isoxazolo[4,3-c]quinolines via chalcones

Madapa, Sudharshan; Sridhar, Divya; Yadav, G P; Maulik, P R; Batra, Sanjay (2007)

A general and practical approach to the synthesis of substituted isoxazolo[4,3-c]quinolines from the substituted isoxazolines afforded by 1,3-dipolar cycloaddition between 2-nitrobenzonitrile oxide and chalcones is described. ...
Synthesis of substituted 1H- and 3H-1-benzazepines: Rearrangement of 2-alkoxycarbonyl-1H-1-benzazepines to isoquinolines

Singh, Vijay; Batra, Sanjay (2007)

The SnCl2-mediated reduction of nitro groups in 2-nitro-4-(2-nitro-benzylidene)-alkanoates and 4-nitro-2-(2-nitro-alkylidene)-alkanoates afforded via SN2′ reaction of ethyl nitroacetate and nitroethane with the acetyl ...
Sodium hydride-mediated cascade reaction towards the synthesis of 1,5-disubstituted uracil from cyanamides derived from the Baylis-Hillman ad-ducts

Yadav, G P; Maulik, P R; Batra, Sanjay; (2007)

Sodium hydride-mediated cascade reaction towards the synthesis of 1,5-disubstituted uracil from cyanamides derived from the Baylis-Hillman ad-ducts
Trifluoroacetic acid: A more effective and efficient reagent for the synthesis of 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones and 3-arylmethyl-2-amino quinolines from Baylis-Hillman derivatives via Claisen rearrangement

Pathak, Richa; Madapa, Sudharshan; Batra, Sanjay (2007)

Trifluoroacetic acid has been discovered to be a highly effective and efficient reagent for the tandem Claisen rearrangement and cyclisation reaction to yield 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones from compounds ...
Convenient synthesis of substituted α-methylene--valerolactones in aqueous medium using Baylis-Hillman chemistry

Singh, Vijay; Batra, Sanjay (2006)

A mild and convenient synthesis of substituted α-methylene--valerolactones was achieved by SN2 nucleophilic substitution of the acetates of the Baylis-Hillman adducts with acetyl acetone followed by one-pot saponification ...
Expeditious synthesis of 5,6,7 ,8-tetrahydro-imidazo[1,2-a ] pyrimidin-2-ones and 3,4,6,7 ,8,9-hexahydro-pyrimido[,2-a ] pyrimidin-2-ones

Pathak, Richa; Batra, Sanjay (2007)

A convenient synthesis of new 5,6,7 ,8-tetrahydro-imidazo[ 1,2-a]pyrimidin-2-ones and 3,4,6,7 ,8,9-hexahydro-pyrimido[1 ,2a]pyrimidin-2- ones from the Baylis-Hillman adducts of acrylonitrile and their derivatives is ...
Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

Batra, Sanjay; Roy, Amrendra K; Patra, A; Bhaduri, A P; Surin, W R; Raghavan, S A V; Sharma, P; Kapoor, Kapil; Dikshit, Madhu (2004)

The solution phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the ...

Now showing items 501-520 of 531

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