Medicinal and Process Chemistry: Recent submissions

Now showing items 461-480 of 531

Nad+ dependent dna ligase (rv3014c) from M. tuberculosis: strategies for inhibitor design

Dube, Divya; Kukshal, Vandna; Srivastava, Sandeep Kumar; Tripathi, R P; Ramachandran, Ravishankar (2008)

NAD+ -dependent DNA ligases (LigA) are essential enzymes found only in bacteria and some virus species. This makes them attractive drug targets. Based on the crystal structure of the NAD+ binding domain of the M. tuberculosis ...
Reductive amination of glycoyl aldoses: synthesis of n-glycosylated beta-glycosyl amino alcohols and their antidiabetic potential

Verma, S S; Mishra, R C; Tamrakar, A K; Tripathi, B K; Srivastava, A K; Tripathi, R P (2004)

Reductive amination of glycosyl aldehydes (1a-1c, 2) with glycosyl amino esters (3a-3c, 4) in presence of sodium borohydride gave diglycosylated amino esters (5-15) in good yields. N-Glycosyl-glycosylated amino esters ...
Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction

Pandey, Jyoti; Dwivedi, Namrata; Srivastava, A K; Tamarkar, A; Tripathi, R P (2007)

1,3-Dipolar cycloaddition of azomethine ylides and glycosyl E-olefins in presence of LDA led to diastereoselective formation of C-glycosylated proline esters. The selected esters on regioselective hydrolysis with LiOH gave ...
DBU assisted Aldol type reaction and elimination: an expeditious synthesis of glycosyl 1,3-dienes via glycosylated beta-hydroxy esters

Verma, Shyam S; Dwivedi, Namrata; Singh, Biswajit K; Tripathi, R P (2006)

A novel method for the synthesis of glycosyl dienes via aldol type condensation has been reported. DBU catalysed condensation of unsaturated glycosyl uronoates with aldehydes produces the corresponding -hydroxy esters, ...
An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid

Singh, Biswajit K; Bisht, Surendra Singh; Tripathi, R P (2006)

A straightforward synthesis of tetramic acid derivatives with dienyl susbstituents at C-5 from L-ascorbic acid is reported. The synthesis involves the PCC oxidation of allylic alcohol followed by olefination and subsequent ...
An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanone: A New Class of Antimycobacterial Agents

Dwivedi, Namrata; Tewari, Neetu; Tiwari, V K; Chaturvedi, Vinita; Manju, Y K; Srivastava, A; Giakwad, A; Sinha, S; Tripathi, R P (2005)

An efficient, high yield and one pot synthesis of phenyl cyclopropyl methanones on reaction of different aryl alcohols with 4’-fluoro-4-chloro-butyrophenone in THF/DMF in presence of NaH /TBAB is reported. All the compounds ...
Wikstrosin, a tricoumarin from Wikstroemia viridiflora

Tandon, Sheela; Rastogi, R P (1977)

In the polar fraction of the extract from Wikstroemia viridiflora,daphnoretin and a new coumarin. wikstrosin,were identified. Wikstrosin has been characterised by chemical and spectral methods as a tricoumarin, a new class ...
Wikstromol, A new lignan from wikstroemia

Tandon, Sheela; Rastogi, R P (1976)
Cycloaddition Reactions: Reaction of 3-Methyl-2-phenylpyrrocoline with Dimethyl Acteylenedicarboxylate

Gupta, C M; Rizvi, R K; Anand, Nitya; Murthy, M R Narsimha; Venkatesan, K (1981)

Reaction of 3-methyl-2-phenylpyrrocoline(I) and dimethyl acetylenedicarboxylate(II) in refluxing toluene furnishes cis-7',8-dihydro.4,5,8,9-tetramethoxycarbonyl-7'-phenyl-7' -methylazocino(2,1,8-cd]pyrrolizine (III) and ...
A New Synthetic Approach to 8-Aza Analogs of Prostaglandins

Kumar, S; Gupta, R C; Gupta, C M; Anand, Nitya (1981)

A new synthetic approach to (dl)-8-aza-13,14-dihydroprostanoic acid and its corresponding 11-hydroxy derivative is described
Studies on Electrophilic Substitution Reactions of 3-Phenyl-cycl[3.2.2]azine

Gupta, C M; Anand, Nitya (1973)

Acetylation and formylation of 3-phenyl-cycl[3.2.2]azine derivatives, in the presence of Lewis acids, have been Investigated. It has been found that the orientation of substitution in 2-carbomethoxy- 3-phenyl-cycl[3.2.2]azine ...
QSAR Studies on Thiazolidines: A Biologically Privileged Scaffold

Prabhakar, Yenamandra S; Solomon, V Raja; Gupta, Manish K; Katti, S B (2006)

A large number of drugs and biologically relevant molecules contain heterocyclic systems. Often the presence of hetero atoms or groupings imparts preferential specificities in their biological responses. Amongst the ...
A Simple Algorithm for Unique Representation of Chemical Structures - Cyclic/ Acyclic Functionalized Achiral Hydrocarbons

Prabhakar, Yenamandra S; Balasubramanian, Krishnan (2006)

An algorithm, based on ‘vertex priority values’ has been proposed to uniquely sequence and represent connectivity matrix of chemical structures of cyclic/ acyclic functionalized achiral hydrocarbons and their derivatives. ...
C-3 Alkyl /Arylalkyl-2,3-dideoxy hex-2-enopyranosides as Antitubercular Agents: Synthesis, Biological Evaluation and QSAR Study

Saquib, Mohammad; Gupta, M K; Sagar, Ram; Prabhakar, Y S; Shaw, A K; Kumar, Rishi; Maulik, P R; Gaikwad, Anil; Sinha, Sudhir; Srivastava, A K; Chaturvedi, Vinita; Srivastava, Ranjana; Srivastava, B S (2007)

A series of C-3 alkyl and arylalky 2,3-dideoxy hex-2-enopyranoside derivatives were synthesized by Morita-Baylis-Hillman reaction using enulosides 4, 5 and 6 and various aliphatic and aromatic aldehydes. The compounds were ...
Topological Descriptors in Modeling the Antimalarial Activity of 4-(3’, 5’-Disubstitutedanilino)quinolines

Gupta, Manish K; Prabhakar, Yenamandra S (2006)

Two series of closely related antimalarial agents, 7-chloro-4-(3’,5’-disubstitutedanilino) quinolines, have been analyzed using Combinatorial Protocol in Multiple Linear Regression (CP-MLR) for the structure-activity ...
Reductase inhibitory activity of some flavones: Topological descriptors in modeling the activity

Prabhakar, Yenamandra S; Gupta, Manish K; Roy, Nobendu; Venkateswarlu, Yenamandra (2006)

In healthy people, glucose is metabolized through Embden-Meyerhoff pathway. In cases of diabetes mellitus, with the increased levels of glucose in insulin-insensitive tissues the Aldose Reductase (AR) in polyol pathway ...
Topological Descriptors in Modeling the HIV Inhibitory Activity of 2-Aryl-3-pyridyl-thiazolidin-4-ones

Prabhakar, Yenamandra S; Rawal, Ravindra K; Gupta, Manish K; Solomon, V Raja; Katti, S B (2005)

The HIV-1 RT inhibitory activity of 2-(2,6-dihalophenyl)-3-(substituted pyridin-2-yl)-thiazolidin-4-ones has been analyzed with different topological descriptors obtained from DRAGON software. Here, simple topological ...
Molecular Surface Features in Modeling the HIV-1 RT Inhibitory Activity of 2-(2,6-Disubstituted phenyl)-3-(substituted pyrimidin-2-yl)-thiazolidin-4-ones

Rawal, Ravindra K; Prabhakar, Yenamandra S; Katti, S B (2007)

The human immunodeficiency virus-1 reverse transcriptase inhibitory activity of 2-(2,6-disubstituted phenyl)-3-(substituted pyrimidin-2-yl)-thiazolidin-4-ones have been analyzed using combinatorial protocol in multiple ...
A Model to quantify Disease state based on the ayurvedic concept of Tridosa

Prabhakar, Yenamandra S; Kumar, Suresh (1993)

The ancient Indian system of Ayurveda revolves around the concept of tridosha namely vata, pitta and kapha. The disturbance in the steady state of these three factors is said to be the starting point of the development of ...
CP-MLR Directed QSAR Studies on the Antimycobacterial Activity of Functionalised Alkenols - Topological Descriptors in Modeling the Activity

Gupta, M K; Sagar, Ram; Shaw, A K; Prabhakar, Yenamandra S (2005)

The antimycobacterial activity of nitro/ acetamido alkenol derivatives and chloro/ amino alkenol derivatives has been analyzed through combinatorial protocol in multiple linear regression (CP-MLR) using different topological ...

Now showing items 461-480 of 531

Search DSpace

Advanced Search

Browse

All of DSpace
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

Medicinal and Process Chemistry: Recent submissions

Search DSpace

Browse

All of DSpace

This Collection

My Account