An efficient approach for the synthesis of indole- and pyrrole-fused diketopiperazines has been developed. This protocol involves the Ugi four-component reaction (U-4CR) followed by an intramolecular cyclization of the Ugi ...

A chiron approach to stereoselective route for the synthesis of aminocytitols from carbohydrates is described. The formal synthesis of (+)-conduramine E and (-)-conduramine E was achieved by utilizing this strategy. The ...

Evidences indicate that inhibition of central Renin angiotensin system (RAS) ameliorates memory impairment in animals and humans. Earlier we have reported involvement of central angiotensin converting enzyme (ACE) in ...

Cancer stem cells (CSCs) are tumor initiating cells within the tumor mass; that play a critical role in cancer pathogenesis.CSCs regulate cancer cell survival,metastatic potential, resistance to conven-tional radio-chemotherapy, ...

A new approach to synthesize a homologous series of 14, 15 and 16-membered drug-like, macrocyclic glycoconjugates involving TBAHS promoted azide-propenone intramolecular cycloaddition in a designed C- glycopyranosyl butenones ...

β-Sitosterol, taraxerol and a triterpene diol, m.p. 268-9°, have been isolated from the bark of M. esculenra. The diol has been isomerized to erythrodiol Indicating C25 as the site of the primary hydroxyl function. It has ...

An efficient, scalable and stereocontrolled synthesis of the entire carbon framework of an actin binding dimeric macrolide rhizopodin has been accomplished in its protected form. The key features of our synthesis include ...

A novel series of light emitting and thermally stable non-aggregating benzannulated quinolines and acridines were designed and prepared from ketene-S,S-acetal under mild conditions through C-C bond formation. Photophysical ...

The applicability of ferric chloride method for the assay of vitamin B6 has been investlgated in the presence of other B-vitamins, amino acids, carbohydrates and Inorganic salts, and it has been shown that the test is ...