Abstract:
An efficient, scalable and stereocontrolled synthesis of the entire carbon framework of an actin binding dimeric macrolide rhizopodin has been accomplished in its protected form. The key features of our synthesis include a titanium catalyzed anti acetal aldol reaction, substrate controlled diastereoslelective prenyl stannylation, Mukaiyama aldol reaction, an indium mediated diastereoselective propargylation and an advanced stage Stille coupling reaction.
