Pharmaceutics: Recent submissions

Now showing items 21-40 of 48

Development of targeted 1, 2-diacyl-sn-glycero-3-phospho-L-serine coated Gelatin nanoparticles loaded with Amphotericin B for improved in vitro and in vivo effect in Leishmaniasis.

Khatik, Renuka; Dwivedi, Pankaj; Khare, Prashant; Kansal, Shaswat; Dube, Anuradha; Mishra, P R; Dwivedi, A K (2014)

bjective: The principle objective of this study was to develop phosphatidylserine (PS) coated gelatin nanoparticles (GNPs) bearing amphotericin B (AmB) for specific targeting to the macrophages involved in visceral ...
Assay method for quality control and stability studies of a new antidiabetic agent (S-001-469)

Khandelwal, Kiran; Pachauri, S D; Tiwari, Khushbu; Pandey, R R; Ahmed, Hafsa; Dwivedi, Pankaj; Dwivedi, A P; Pratap, Ram; Dwivedi, A K (2014)

In the present study, for the first time, HPLC method of CDRI compound S-001-469 is reported, S-001-469 is a new potential substituted chalcone based antidiabetic candidate drug under preclinical development phase. The ...
In-vitro and in-vivo Studies on Novel Chitosan-g-Pluronic F-127 Copolymer Based Nanocarrier of Amphotericin B for Improved Antifungal Activity

kumar, Vivek; Gupta, P K; Pawar, V K; Verma, Ashwni; Khatik, Renuka; Tripathi, Priyanka; Shukla, Prasant; Yadav, Bholenath; Parmar, Jeetesh; Dixit, Rohit; Mishra, P R; Dwivedi, A K (2014)

The present communication is focusing on development of safe nanotemplates for sustained delivery of amphotericin B (AmB). We synthesized a block copolymer based on chitosan and Pluronic F-127 (PEO–b–PPO–b–PEO). Selection ...
The preparation of Morinda citrifolia (Noni)–phospholipid complex and its pharmacokinetics study in rats

Pachauri, S D; Khandelwal, Kiran; Bhaisora, Madhusmita; Pandey, R R; Shrivastava, Akansha; Tripathi, Priyanka; Verma, P R P; Dwivedi, A K (2014)

Morinda citrifolia L. (NONI) fruits have been used for thousands of years for the treatment of many health problems including cancer, cold, diabetes, flu, hypertension, and pain. Plant extracts have reported several ...
Toxicological evaluation and targeting tumor cells through folic acid modified guar gum nanoparticles of curcumin

Khatik, Renuka; Dwivedi, Pankaj; Upadhyay, Mansi; Patel, V K; Paliwal, S K; Dwivedi, A K (2014)

The investigation was aimed for designing pH-sensitive, polymeric surface modified Guar Gum Nanoparticles (GgNP) with Folic acid (FA) loaded with curcumin (CU), a natural anti-cancer agent, for the treatment of colon cancer ...
Single-nucleotide polymorphic macrophage cytokine regulation by Mycobacterium tuberculosis and drug treatment

Singh, A K; Yadav, A B; Garg, Rajiv; Misra, Amit (2014)

Aims: To investigate survival of Mycobacterium tuberculosis in primary macrophages with single nucleotide polymorphisms (SNPs) affecting cytokine secretion, under treatment with drugs in solution or microparticles. Materials ...
Chitosan Coated Hydroxypropyl Methylcellulose- Ethylcellulose Shell Based Gastroretentive Dual Working System to Improve the Bioavailability of Norfloxacin

Pawar, V K; Asthana, Shalini; Mishra, Neelam; Chaurasia, Mohini; Chourasia, M K (2013)

This investigation was aimed to formulate, evaluate and optimize a gastroretentive dual working system based on mucoadhesion and floating mechanisms to improve bioavailability of norfloxacin (NFX). Floating microballoons ...
Polymeric Colloidal Particulate Systems: Intelligent Tools for Intracellular Targeting of Antileishmanial Cargos

Asthana, Shalini; Gupta, P K; Chaurasia, Mohini; Dube, Anuradha; Chourasia, M K (2013)

Introduction: Targeted cargo delivery systems can overcome drawbacks associated with antileishmanials delivery, by defeating challenges of physiological barriers. Various colloidal particulate systems have been developed ...
Inhalable Particles Containing Rapamycin for Induction of Autophagy in Macrophages Infected with Mycobacterium Tuberculosis

Gupta, Anuradha; Pant, Garima; Mitra, Kalyan; Madan, Jitender; Chourasia, M K; Misra, Amit (2014)

We investigated whether particles suitable for delivery to alveolar macrophages may provide a means of targeting rapamycin, an inducer of autophagy, to alveolar macrophages as a host-directed anti-tuberculosis agent. ...
Covalent functionalized Self-assembled Lipo-polymerosome bearing Amphotericin B for better management of leishmaniasis and its toxicity evaluation

Gupta, P K; Jaiswal, A K; Kumar, Vivek; Verma, Ashwni; Dwivedi, Pankaj; Dube, Anuradha; Mishra, P R (2014)

Amphotericin B remains the preferred choice for leishmanial infection, but has limited clinical applications due to substantial dose limiting toxicities. In the present work, AmB has been formulated in Lipo-polymerosome ...
Exploiting 4-sulphate N-acetyl galactosamine decorated gelatin nanoparticles for effective targeting to professional phagocytes in vitro and in vivo

Dwivedi, Pankaj; Kansal, Shaswat; Sharma, Monika; Shukla, Rahul; Verma, Ashwini; Shukla, Prashant; Tripathi, Priyanka; Gupta, Pramod; Saini, Deepika; Khandelwal, Kiran; Verma, Rahul; Dwivedi, A K; Mishra, P R (2012)

The present study was focused on the development of surface modified gelatin nanoparticles (SGNPs) using novel ligand 4-sulfated N-acetyl galactosamine (4-SO4GalNAc) for specific targeting to macrophages. The gelatin has ...
Access to di- and tri-Substituted Oxazoles via an NBS-Mediated Oxidative Cyclisation of N-acylaminoacid Derivatives†

Bathula, S R; Reddy, M P; Viswanadham, K K D R; Sathyanarayana, Pochampalli; Reddy, M S (2013)

A remarkably simple method for the synthesis of various di- and tri-substituted functionalized oxazoles is described in metal or any catalyst free conditions. An iterative bromination and debromination of N-acylated aminoacid ...
Immunoadjuvant chemotherapy of visceral leishmaniasis in hamsters using Amphotericin B encapsulated nano-emulsion template based chitosan nanocapsules

Asthana, Shalini; Jaiswal, A K; Gupta, P K; Pawar, V K; Dube, Anuradha; Chourasia, M K (2013)

The accessible treatment options for life-threatening neglected visceral leishmaniasis (VL) disease have problems regarding efficacy, stability, adverse effects and cost, making treatment a complex issue. Herein, we ...
Paper Chromatographic Analysis of Acids -Horizontal Migration Method: Part IV*

Mohan Rao, V K (1955)

The Rf values of different organic acids and phenols have been determined employing the modified Rutter's technique of paper chromatography and basic solvents. The Rf values of aliphatic acids suggest that a clear separation ...
Investigations on Alternate Approach to Target Mannose Receptors on Macrophages using 4-Sulfated N-Acetyl Galactosamine more Efficiently as Compared to Mannose Decorated Liposomes: an Application in Drug Delivery

Singodia, Deepak; Verma, Ashwni; Verma, R K; Mishra, P R (2012)

In the present study the targeting potential of two different ligands i.e palmitoyl mannose (Man-Lip) and 4-SO4GalNAc (Sulf-Lip) to resident macrophages have been investigated after having decorated on the surface of ...
Industrial Perspective of Gastroretentive Drug Delivery Systems: Physiochemical, Biopharmaceutical, Technological and Regulatory Consideration

Pawar, V K; Kansal, Shaswat; Asthana, Shalini; Chourasia, M K (2012)

Introduction: Concerning patient compliance, oral route is the most promising drug delivery route. Gastroretentive drug delivery systems (GRDDS) can overcome drawbacks associated with oral drug delivery by defeating natural ...
Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to Rhesus macaques

Verma, R K; Mukker, J K; Singh, R S P; Kumar, Kaushlendra; Verma, P R P; Misra, Amit (2012)

Dry powder inhalations (DPI) of microparticles containing isoniazid (INH) and rifabutin (RFB) are under preclinical development for use in pulmonary tuberculosis. Microparticles containing 0.25, 2.5 or 25 mg of each drug ...
Inhaled therapies for tuberculosis and the relevance of activation of lung macrophages by particulate drug delivery systems

Verma, R K; Singh, A K; Mohan, Mradul; Agrawal, A K; Misra, Amit (2011)

Pathogenic strains of M. tuberculosis (Mtb) induce 'alternative activation' of lung macrophages that they colonise, in order to create conditions that promote the establishment and progression of infection. There is some ...
The Devil’s Advocacy: When and Why Inhaled Therapies for Tuberculosis May Not Work

Yadav, A B; Singh, A K; Verma, R K; Mohan, Mradul; Agrawal, A K; Misra, A (2011)

Factors that are inimical to the success of inhaled therapies for tuberculosis (TB) include: (i) lack of access of inhaled therapies to poorly-aerated areas of the tubercular lung; (ii) limited ability to penetrate biofilms ...
Chitosan based macrophage mediated drug targeting for the treatment of experimental visceral leishmaniasis

Kunjachan, Sijumon; Gupta, Swati; Dwivedi, A K; Dube, Anuradha; Chourasia, M K (2011)

The potential of chitosan microparticles as a carrier of doxorubicin for the treatment of visceral leishmaniasis was evaluated by macrophage mediated drug targeting approach. Cationic charge of doxorubicin was masked by ...

Now showing items 21-40 of 48

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