Access to di- and tri-Substituted Oxazoles via an NBS-Mediated Oxidative Cyclisation of N-acylaminoacid Derivatives†

Abstract

A remarkably simple method for the synthesis of various di- and tri-substituted functionalized oxazoles is described in metal or any catalyst free conditions. An iterative bromination and debromination of N-acylated aminoacid derivatives using NBS as the sole reagent cleanly led to various substituted oxazoles.