Browsing Pharmaceutics by Issue Date

Now showing items 1-20 of 48

Paper Chromatographic Analysis of Acids -Horizontal Migration Method: Part IV*

Mohan Rao, V K (1955)

The Rf values of different organic acids and phenols have been determined employing the modified Rutter's technique of paper chromatography and basic solvents. The Rf values of aliphatic acids suggest that a clear separation ...
Inhalable microparticles containing large payload of antituberculosis

Kaur, Jatinder; Kumar, Kaushlendra; Yadav, A B; Sharma, Rolee; Misra, Amit; (2007)

Microparticles containing large payloads of two anti-tuberculosis (TB) drugs were prepared and evaluated for suitability as a dry powder inhalation targeting alveolar macrophages. A solution containing one part each of ...
Inhalable Microparticles Containing Large Payload of Anti-tuberculosis Drugs

Muttil, Pavan; Kaur, Jatinder; Kumar, Kaushlendra; Yadav, A B; Sharmaa, Rolee; Misra, Amit (2007)

Microparticles containing large payloads of two anti-tuberculosis (TB) drugs were prepared and evaluated for suitability as a dry powder inhalation targeting alveolar macrophages. A solution containing 1 part each of ...
Uptake of inhalable microparticles affects defense responses of macrophages infected with Mycobacterium tuberculosis H37Ra.

Sharma, Rolee; Muttil, Pavan; Yadav, A B; Rath, S K; Bajpai, V K; Mani, Uthirappan; Misra, Amit (2007)
A Hand-Held Apparatus for “Nose-Only” Exposure of Mice to Inhalable Microparticles as a Dry Powder Inhalation Targeting Lung and Airway Macrophages

Kaur, Jatinder; Muttil, Pavan; Kumar, Kaushlendra; Verma, Rahul; Yadav, A B; Sharma, Rolee; Misra, Amit (2008)

A hand-held apparatus designed for the purpose of administering dry powder inhalations to rodents by “Nose-only” exposure was standardized. An aerosol of microparticles containing the anti-tuberculosis drugs isoniazid and ...
Inhalable Microparticles Containing Isoniazid and Rifabutin Target Macrophages and “Stimulate the Phagocyte” to Achieve High Efficacy

Yadav, A B; Sharma, Rolee; Muttil, Pavan; Singh, A K; Verma, R K; Mohan, Mradul; Patel, S K; Misra, Amit (2009)

Macrophage responses to infection with Mycobacterium tuberculosis (MTB) and treatment with soluble isoniazid (INH) plus rifabutin (RFB) versus microparticles containing equivalent amounts of drugs were compared. It was ...
Inhalable Microparticles Containing Isoniazid and Rifabutin Target Macrophages and “Stimulate the Phagocyte” to Achieve High Efficacy

Yadav, A B; Sharma, Rolee; Muttil, Pavan; Singh, A K; Verma, R K; Mohan, Mradul; Patel, S K; Misra, Amit (2009)

Macrophage responses to infection with Mycobacterium tuberculosis (MTB) and treatment with soluble isoniazid (INH) plus rifabutin (RFB) versus microparticles containing equivalent amounts of drugs were compared. It was ...
Inhaled therapies for tuberculosis and the relevance of activation of lung macrophages by particulate drug delivery systems

Verma, R K; Singh, A K; Mohan, Mradul; Agrawal, A K; Misra, Amit (2011)

Pathogenic strains of M. tuberculosis (Mtb) induce 'alternative activation' of lung macrophages that they colonise, in order to create conditions that promote the establishment and progression of infection. There is some ...
The Devil’s Advocacy: When and Why Inhaled Therapies for Tuberculosis May Not Work

Yadav, A B; Singh, A K; Verma, R K; Mohan, Mradul; Agrawal, A K; Misra, A (2011)

Factors that are inimical to the success of inhaled therapies for tuberculosis (TB) include: (i) lack of access of inhaled therapies to poorly-aerated areas of the tubercular lung; (ii) limited ability to penetrate biofilms ...
Chitosan based macrophage mediated drug targeting for the treatment of experimental visceral leishmaniasis

Kunjachan, Sijumon; Gupta, Swati; Dwivedi, A K; Dube, Anuradha; Chourasia, M K (2011)

The potential of chitosan microparticles as a carrier of doxorubicin for the treatment of visceral leishmaniasis was evaluated by macrophage mediated drug targeting approach. Cationic charge of doxorubicin was masked by ...
SiRNA Delivery Challenges and Role of carrier Systems

Shegokar, R; Al Shaal, L; Mishra, P R (2011)

Gene silencing by RNA interference has rapidly growing area of therapeutic for managing diseases. Besides research advances in this direction, the poor cellular uptake of synthetic small interfering RNAs is a major impediment ...
Untitled

Unknown author (2011-08-18)

Gene silencing by RNA interference has rapidly growing area of therapeutic for managing diseases. Besides research advances in this direction, the poor cellular uptake of synthetic small interfering RNAs is a major impediment ...
Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to Rhesus macaques

Verma, R K; Mukker, J K; Singh, R S P; Kumar, Kaushlendra; Verma, P R P; Misra, Amit (2012)

Dry powder inhalations (DPI) of microparticles containing isoniazid (INH) and rifabutin (RFB) are under preclinical development for use in pulmonary tuberculosis. Microparticles containing 0.25, 2.5 or 25 mg of each drug ...
Investigations on Alternate Approach to Target Mannose Receptors on Macrophages using 4-Sulfated N-Acetyl Galactosamine more Efficiently as Compared to Mannose Decorated Liposomes: an Application in Drug Delivery

Singodia, Deepak; Verma, Ashwni; Verma, R K; Mishra, P R (2012)

In the present study the targeting potential of two different ligands i.e palmitoyl mannose (Man-Lip) and 4-SO4GalNAc (Sulf-Lip) to resident macrophages have been investigated after having decorated on the surface of ...
Industrial Perspective of Gastroretentive Drug Delivery Systems: Physiochemical, Biopharmaceutical, Technological and Regulatory Consideration

Pawar, V K; Kansal, Shaswat; Asthana, Shalini; Chourasia, M K (2012)

Introduction: Concerning patient compliance, oral route is the most promising drug delivery route. Gastroretentive drug delivery systems (GRDDS) can overcome drawbacks associated with oral drug delivery by defeating natural ...
Exploiting 4-sulphate N-acetyl galactosamine decorated gelatin nanoparticles for effective targeting to professional phagocytes in vitro and in vivo

Dwivedi, Pankaj; Kansal, Shaswat; Sharma, Monika; Shukla, Rahul; Verma, Ashwini; Shukla, Prashant; Tripathi, Priyanka; Gupta, Pramod; Saini, Deepika; Khandelwal, Kiran; Verma, Rahul; Dwivedi, A K; Mishra, P R (2012)

The present study was focused on the development of surface modified gelatin nanoparticles (SGNPs) using novel ligand 4-sulfated N-acetyl galactosamine (4-SO4GalNAc) for specific targeting to macrophages. The gelatin has ...
Immunoadjuvant chemotherapy of visceral leishmaniasis in hamsters using Amphotericin B encapsulated nano-emulsion template based chitosan nanocapsules

Asthana, Shalini; Jaiswal, A K; Gupta, P K; Pawar, V K; Dube, Anuradha; Chourasia, M K (2013)

The accessible treatment options for life-threatening neglected visceral leishmaniasis (VL) disease have problems regarding efficacy, stability, adverse effects and cost, making treatment a complex issue. Herein, we ...
Access to di- and tri-Substituted Oxazoles via an NBS-Mediated Oxidative Cyclisation of N-acylaminoacid Derivatives†

Bathula, S R; Reddy, M P; Viswanadham, K K D R; Sathyanarayana, Pochampalli; Reddy, M S (2013)

A remarkably simple method for the synthesis of various di- and tri-substituted functionalized oxazoles is described in metal or any catalyst free conditions. An iterative bromination and debromination of N-acylated aminoacid ...
Chitosan Coated Hydroxypropyl Methylcellulose- Ethylcellulose Shell Based Gastroretentive Dual Working System to Improve the Bioavailability of Norfloxacin

Pawar, V K; Asthana, Shalini; Mishra, Neelam; Chaurasia, Mohini; Chourasia, M K (2013)

This investigation was aimed to formulate, evaluate and optimize a gastroretentive dual working system based on mucoadhesion and floating mechanisms to improve bioavailability of norfloxacin (NFX). Floating microballoons ...
Polymeric Colloidal Particulate Systems: Intelligent Tools for Intracellular Targeting of Antileishmanial Cargos

Asthana, Shalini; Gupta, P K; Chaurasia, Mohini; Dube, Anuradha; Chourasia, M K (2013)

Introduction: Targeted cargo delivery systems can overcome drawbacks associated with antileishmanials delivery, by defeating challenges of physiological barriers. Various colloidal particulate systems have been developed ...

Now showing items 1-20 of 48

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