Abstract:
Gene silencing by RNA interference has rapidly growing area of therapeutic for managing diseases. Besides research advances in this direction, the poor cellular uptake of synthetic small interfering RNAs is a major impediment for their clinical applications. Polymer and lipid-based systems are attractive carrier systems for delivery of siRNA and provides option of desirable engineering of carriers particles. In this review, a detailed discussion is done about RNAi delivery systems and recent advances in the field.
