Cu(I)-Catalyzed Tandem Decarboxylative/C-H Activation Coupling reaction of Cyclic diketone, Proline and Alkyne: Synthesis of α-alkynylated pyrrolidine-oxyindoles

Abstract

An efficient ligand/base and oxidant-free copper(I) catalyzed intermolecular direct alkynylation (IDA) strategy has been developed for the synthesis of α-alkynylated pyrrolidine-oxindole derivatives using cyclic diketones, amino acid and alkyne via tandem decarboxylative/C-H activation and reductive-amination strategy.