CSIR-CDRI Publications: Recent submissions

Now showing items 341-360 of 1093

Synthesis of 1,2,4- trioxepanes and 1,2,4-trioxanes via H2O2 me-diated reaction of tertiary carbinols

Ravi, Makthala; Anand, Devireddy; Maurya, Ranjani; Chauhan, Parul; Naikade, N K; Shukla, S K; Yadav, P P (2013)

A facile and efficient method for the synthesis of 1, 2, 4-trioxepanes and 1, 2, 4-trioxanes from differ-ent carbinols having cyclopropyl and phenyl substituents have been explored. The corresponding hy-droxyhydroperoxides ...
A highly efficient ultrasound-promoted synthesis of 2,3-disubstituted benzo[b]furans via intramolecular C-C bond formation in ionic liquid[bmim]BF4 at room temperature

Yadav, Nisha; Hussain, M K; Ansari, M I; Gupta, P K; Hajela, Kanchan (2013)

An efficient ultrasound promoted synthesis of 2, 3-disubstituted benzo[b]furans in the ionic liquid, [bmim]BF4 at room temperature is reported. 5-exo-dig carbanion-yne intramolecular cyclization is mediated using anhydrous ...
Antifilarial diarylheptanoids from Alnus nepalensis leaves growing in high altitude areas of Uttarakhand, India

Yadav, Deepti; Singh, S C; Verma, R K; Saxena, Kirti; Verma, Richa; Murthy, P K; Gupta, M M (2013)

Lymphatic filariasis continues to be a major health problem in tropical and subtropical countries. A macrofilaricidal agent capable of eliminating adult filarial parasites is urgently needed. Platyphyllenone (A), alusenone ...
DART MS Based Chemical Profiling for Therapeutic Potential of Piper betle Landraces

Bajpai, Vikas; Pandey, Renu; Negi, M P S; Kumar, Nikhil; Kumar, Brijesh (2013)

Piper betle Linn.leaves are traditionally used as a folk medicine in India and other Asiatic countries. Twenty-one P. betle landraces were analyzed using a Direct Analysis in Real Time (DART) mass spectral technique and ...
Rotenone induced neurotoxicity in rat brain areas: A study on neuronal and neuronal supportive cells

Swarnkar, Supriya; Goswami, Poonam; Kamat, P K; Patro, I K; Singh, Sarika; Nath, Chandishwar (2013)

The present study was conducted to correlate rotenone-induced neurotoxicity with cellular and molecular modifications in neuronal and neuronal supportive cell in rat brain regions. Rotenone was administered (3, 6 and ...
Diastereomeric mixture of calophyllic acid and isocalophyllic acid stimulates glucose uptake in skeletal muscle cells: Involvement of PI-3-Kinase- and ERK1/2-dependent pathways

Prasad, Janaki; Maurya, C K; Pandey, Jyotsana; Jaiswal, Natasha; Madhur, Gaurav; Srivastava, A K; Narender, Tadigoppula; Tamrakar, A K (2013)

The diastereomeric mixture of calophyllic acid and isocalophyllic acid (F015) isolated from the leaves of Calophyllum inophyllum was investigated for the metabolic effect on glucose transport in skeletal muscle cells. In ...
Conjugation Driven Cascade Approach to Enantiopure Pyrano-Fused 1,5-Benzodiazepines by Tandem Condensation-[3,3] Sigmatropic Rearrangement-Aza-Michael Addition-Elimination

Husain, Irfan; Saquib, Mohammad; Shaw, A K (2013)

Sugar based Morita-Baylis-Hillman (MBH) acetates easily obtained from commercially available D-glucal underwent rapid reaction with different o-phenylenediamines to afford a series of novel enantiomerically pure tricyclic ...
Iodine-mediated intramolecular electrophilic aromatic cyclization in allylamines: A general route to synthesis of quinolines, pyrazolo[4,3-b]pyridines and thieno[3,2-b]pyridines§

Batchu, Harikrishna; Bhattacharyya, Soumya; Batra, Sanjay (2012)

An unprecedented synthesis of aromatic ring annulated pyridines from suitably substituted primary allylamines via intramolecular electrophilic aromatic cyclization mediated by molecular iodine under mild conditions is described.
Callus culture and in vitro biosynthesis of cardiac glycosides from Calotropis gigantea (L.) Ait.

Tripathi, P K; Awasthi, Shikha; Kanojiya, Sanjeev; Tripathi, Vineeta; Mishra, D K (2013)

Calotropis gigantea (L.) Ait. belonging to the family Asclepiadaceae, is a source of many cardiac glycosides (CGs) and their steroidal moieties (genins). These CGs have been reported to have anti-proliferative activity on ...
Chemoselective synthesis of polyfunctional aminophenyl 2-oxobut-3-enyl - and quinoline-methyl-C-glycopyranosides from nitrophenyl 2-oxobut-3-enyl C-glycopyranosides under ultrasonic vibrationф

Ramakrishna, K K G; Ajay, Arya; Sharma, Anindra; Tripathi, R P (2013)

Chemoselective reduction of nitro group in polyfunctional nitrophenyl 2-oxobut-3-enyl C-glycopyranosides to the respective aminophenyl 2-oxobut-3-enyl glycopyranosides with SnCl2.2H2O under ultrasonic vibration in good ...
Synthesis and Insight into the Structure – Activity Relationships of Chalcones as Antimalarial Agents

Tadigoppula, Narender; Korthikunta, Venkateswarlu; Gupta, Shweta; Kancharla, Papireddy; Khaliq, Tanvir; Soni, Awakash; Srivastava, R K; Srivastava, Kumkum; Puri, S K; Raju, K S R; Wahajuddin; Sijwali, P S; Kumar, Vikash; Siddiqi, M I (2013)

Licochalcone A (I) isolated from the roots of Chinese licorice, is the most promising antimalarial compound reported so far. In continuation of our drug discovery program, we isolated two similar chalcones, medicagenin ...
Confirmation towards establishing antidiabetic activity in heart wood of Pterocarpus marsupium and analysis of phytoconstituents

Mishra, Akansha; Srivastava, Rohit; Srivastava, S P; Gautam, Sudeep; Maurya, Rakesh; Tamrakar, A K; Srivastava, A K (2013)

The crude powder, ethanolic extract and aqueous, chloroform, hexane and n-butanol soluble fractions of ethanolic extract of heart wood of Pterocarpus marsupium (Family: Fabaceae) showed marked improvement on oral glucose ...
Silica supported perchloric acid catalysed rapid N-formylation under solvent free conditions

Ansari, M I; Hussain, M K; Yadav, Nisha; Gupta, P K; Hajela, Kanchan (2012)

A rapid and chemoselective method for the N-formylation of structurally diverse amines using silica supported perchloric acid (HClO4-SiO2) at room temperature and under solvent free conditions has been developed. The ...
Copper-catalysed synthesis of substituted isoindolo[2,1-a]quinoxalines and isoindolo[2,1-a]quinoxalin-6(5H)-ones§

Biswas, Subhasish; Batra, Sanjay (2013)

An operationally simple and efficient cascade strategy to access substituted isoindolo[2,1-a]quinoxalines via one step copper-catalysed C-N coupling of substituted 2H-isoindole-1-carbaldehyde and substituted 2-halophenylamines ...
Accessing a small library of pluripotent 1,4,5-trisubstituted 1H-1,2,3-triazoles via diversity oriented synthesis

Ajay, Arya; Gupt, M P; Devender, N; Tripathi, R P (2012)

Diversity oriented synthesis of structurally diverse, novel and small drug like molecules based on 1,4,5-trisubstituted 1,2,3-triazoles is developed in a streamlined sequence of different sets of reactions. The method ...
Potent Natural Aphrodisiacs For The Management Of Erectile Dysfunction And Male Sexual Debilities

Singh, A P; Singh, Rajender (2012)

Drugs derived from natural resources have always been considered safe and overall health promoting, since in addition to the active ingredients required for treating the disorder, they also provide various nutritional ...
I2-mediated diversity oriented diastereoselective synthesis of amino acids derived trans-2,5-disubstituted morpholines, piperazines and thiomorpholines

Bera, Saurav; Panda, Gautam (2012)

Diastereoselective trans-2,5-disubstituted amino acids derived diverse morpholines, piperazines and thiomorpholines were prepared in 30 min-1 h with high yields through iodine-mediated 6-exo-trig type cyclization from a ...
Engineering of indole-based tethered biheterocyclic alkaloid Meridianin into -carboline derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization.

Agarwal, P K; Dathi, M D; Saifuddin, Mohammad; Kundu, Bijoy (2012)

A mild, efficient and versatile method has been developed for the construction of functionalized natural product (Meridianin) and its post conversion to pyrimido-β-carboline using cationic π- cyclization. The strategy ...
Intravenous Pharmacokinetics and Oral Bioavailability of Biochanin A in Female Rats

Singh, S P; Wahajuddin; Jain, G K (2011)

Biochanin A (BCA) is a methoxylated isoflavone which is the major constituent in red clover and in commercially available extracts of this plant. The objective of the present study was to evaluate the bioavailability and ...
Gedunin and Photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host

Misra, Sweta; Verma, Meenakshi; Mishra, S K; Srivastava, Shishir; Lakshmi, Vijai; Bhattacharya-Misra, Shailja (2011)

The present study is aimed to evaluate antifilarial activity of Xylocarpus granatum (fruit from Andaman) against human lymphatic filarial parasite Brugia malayi in vivo. The in vitro antifilarial activity has already been ...

Now showing items 341-360 of 1093

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