Abstract:
An operationally simple and efficient cascade strategy to access substituted isoindolo[2,1-a]quinoxalines via one step copper-catalysed C-N coupling of substituted 2H-isoindole-1-carbaldehyde and substituted 2-halophenylamines has been developed. Another straightforward procedure to prepare substituted isoindolo[2,1-a]quinoxalin-6(5H)-ones involving transformation of substituted 2H-isoindole-1-carboxylic acids to acid chloride, coupling with substituted 2-iodophenylamines and copper-catalysed C-N coupling is described.
