The copper-catalyzed cascade reaction comprising of condensation/ α-arylation between 2-halobenzaldehydes and α-amino acid esters provides a straightforward methodology for the efficient synthesis of 2H-isoindole-1-carboxylates

A stereoselective synthesis of the C1-C15 fragment of a G-actin binding natural macrodiolide, rhizopodin was achieved using, as key steps, highly stereoselective acetate aldol reactions to build the C1-C7 fragment, one pot ...

Epitope tagging of yeast proteins has become an efficient tool for biochemical analysis of protein of interest. The epitope-tagged proteins can be used for western blotting, immunoprecipitation and immunofluorescence ...

Present study was undertaken to assess the chronology of major pathological events associated with high cholesterol (HC) diet and their modulation by anti-platelet drugs. Male Golden Syrian hamsters were fed HC diet up to ...

A Morita-Baylis-Hillman reaction mediated approach to formal total synthesis of Oseltamivir and total synthesis of Gabaculine is described. The strategy involves enantiocontrolled preparation of Corey's intermediate in 22% ...

The in vitro blood stage antiplasmodial activity of a series of allylated chalcones based on the licochalcone A as lead molecule was investigated against chloroquine (CQ) sensitive Pf3D7 and CQ resistant PfINDO strains of ...

Thiourea and guanidine substructural units are of significant importance as the compounds containing these core units either in the open or the cyclic form are known to display an array of pharmacological properties. This ...

Blood and plasma are the biomatrices traditionally used for drug monitoring and their pharmacokinetic profiling. Blood is the circulating fluid in contact with all organs and tissues of body and thus, is the most representative ...

Controlled Cascade. A divergent, diastereoselective and efficient synthesis of allocolchicinoids from allylamides prepared from Morita-Baylis-Hillman adducts, via a cascade Suzuki-Michael-Carbocyclization sequence is ...

An efficient iodine-mediated electrophilic tandem cyclization of substituted 2-alkynylbenzaldehydes with anthranilic acids under basic medium leading to iodo-1,2-dihydroisoquinoline-fused benzoxazinones is presented. Success ...