Morita-Baylis-Hillman Approach toward Formal Total Synthesis of Tamiflu and Total Synthesis of Gabaculine§

Abstract

A Morita-Baylis-Hillman reaction mediated approach to formal total synthesis of Oseltamivir and total synthesis of Gabaculine is described. The strategy involves enantiocontrolled preparation of Corey's intermediate in 22% yields starting from N-Boc L-serine methyl ester over 11 steps