CSIR-CDRI Publications: Recent submissions

Now showing items 281-300 of 1093

Potassium carbonate mediated unusual transformation of 2,3-dihydroquinazolinone via Cascade reaction

Sharma, Moni; Mahar, Rohit; Shukla, S K; Kant, Ruchir; Chauhan, P M S (2013)

An unusual potassium carbonate mediated transformation of 2,3-dihydroquinazolinone by a one-pot operation is reported under mild conditions. In addition, it is interesting to report the regioselective transformation of ...
Synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines via cascade imination/intramolecular decarboxylative coupling

Pandey, Garima; Bhowmik, Subhendu; Batra, Sanjay (2013)

A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines is described involving the implementation of a cascade imination/ intramolecular decarboxylative coupling between ...
Disorganized muscle protein-1 (DIM-1) of filarial parasite Brugia malayi: cDNA cloning, expression, purification, structural modeling and its potential as vaccine candidate for human filarial infection

Kushwaha, Vikas; Kumar, Vikash; Verma, S K; Sharma, Rolee; Siddiqi, M I; Murthy, P K (2014)

We have recently identified disorganized muscle protein-1 (DIM-1) in one of the proinflammatory fractions of the human filaria Brugia malayi adult worm. The present study was undertaken to characterize B. malayi DIM-1 ...
Indian Traditional Therapies and Bio-Prospecting: Their Role in Drug Development Research

Sharma, Chetan; Rajendar, Kandhikonda; Kumari, Tejaswita; Arya, K R (2014)

Exploration of biological diversity for identification of novel bioactive molecules or therapeutically more potential than the marketed products is a continuous ongoing process for drug development research. Indian traditional ...
Setaria Cervi Antigen Fraction For Serodiagnosis Of Human Lymphatic Filariasis By Dot-Elisa

Priyadarshi, Priyanka; Kaushal, D C; Tandon, Ashish; Ali, Shakir; Kaushal, N A (2014)

A partially purified antigen fraction of Setaria cervi was used in Dot-enzyme linked immunosorbent assay (Dot-ELISA) for detection for filaria–specific antibodies in W. bancrofti infected patient sera. The S. cervi adult ...
Inhalable Particles Containing Rapamycin for Induction of Autophagy in Macrophages Infected with Mycobacterium Tuberculosis

Gupta, Anuradha; Pant, Garima; Mitra, Kalyan; Madan, Jitender; Chourasia, M K; Misra, Amit (2014)

We investigated whether particles suitable for delivery to alveolar macrophages may provide a means of targeting rapamycin, an inducer of autophagy, to alveolar macrophages as a host-directed anti-tuberculosis agent. ...
Combination of Liposomal CpG Oligodeoxynucleotide 2006 and Miltefosine Induces Strong Cell-Mediated Immunity during Experimental Visceral Leishmaniasis

Shivahare, Rahul; Vishwakarma, Preeti; Parmar, Naveen; Yadav, P K; Haq, Wahajul; Srivastava, Mrigank; Gupta, Suman; Kar, Susanta (2014)

Immuno-modulators in combination with antileishmanial drug miltefosine is a better therapeutic approach for treatment of Visceral Leishmaniasis (VL) as it not only reduces the dose and toxicity of miltefosine but also ...
A unique dithiocarbamate chemistry during design & synthesis of novel sperm-immobilizing agents#

Jangir, Santosh; Bala, Veenu; Lal, Nand; Kumar, Lalit; Sarswat, Amit; Kumar, Lokesh; Kushwaha, Bhavana; Singh, Pratiksha; Shukla, P K; Maikhuri, J P; Gupta, Gopal; Sharma, V L (2014)

- substituted piperazinecarbodithioates were obtained by an unusual removal of CS2 in benzyl substituted dithiocarbamate derivatives under acid and basic conditions during design and synthesis of 1, 4-(disubstituted)pipe ...
Covalent functionalized Self-assembled Lipo-polymerosome bearing Amphotericin B for better management of leishmaniasis and its toxicity evaluation

Gupta, P K; Jaiswal, A K; Kumar, Vivek; Verma, Ashwni; Dwivedi, Pankaj; Dube, Anuradha; Mishra, P R (2014)

Amphotericin B remains the preferred choice for leishmanial infection, but has limited clinical applications due to substantial dose limiting toxicities. In the present work, AmB has been formulated in Lipo-polymerosome ...
Drug/drug interaction of common NSAIDs with antiplatelet effect of aspirin in human platelets

Saxena, Aaruni; Balaramnavar, V M; Hohlfeld, Thomas; Saxena, A K (2013)

Nonsteroidal anti-inflammatory drugs (NSAIDs) may interfere with the anti-platelet activity of aspirin at the level of the platelet cyclooxygenase-1 (COX-1) enzyme. In order to examine the interference of common NSAIDs ...
DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast

Yadav, Sudhanshu; Verma, S K; Ahmed, Shakil (2011)

DNA topoisomerases are specialized nuclear enzymes that perform topological modifications on double stranded DNA and hence are essential for DNA metabolism such as replication, transcription, recombination, condensation ...
Cloning, overexpression, purification and preliminary X-ray analysis of a Feast/famine regulatory protein (Rv2779c) from Mycobacterium tuberculosis H37Rv

Dey, Abhishek; Ramachandran, Ravishankar (2014)

Rv2779c from M. tuberculosis is a Feast/Famine regulatory protein also known as Leucine responsive regulatory protein/Asparagine synthase C- family (Lrp/AsnC) of transcriptional regulators. This class of proteins is known ...
Cu-Catalyzed Conversion of Propargyl Acetates to E-α,β-Unsaturated Amides via Ketenimine Formation with Sulfonyl Azides

Kumar, Y K; Kumar, G R; Reddy, M S (2014)

The reaction between readily accessible propargyl acetates and sulfonyl azides in presence of CuI catalyst yielded trans α, β-unsaturated N-tosylamides via N-sulfonyl ketimine formation followed by a probable 1,3-OAc ...
Some Indian Traditional Medicinal Plants with Antioxidant Activity: A Review

Katiyar, Shikhar; Patidar, Devendra; Gupta, Shailja; Singh, R K; Singh, Poonam (2013)

Since the beginning of human civilization, a number of Indian medicinal plants have been used in the traditional system of medicine (Ayurveda), aiming to maintain health and to cure diseases. Oxidative stress has emerged ...
An actin-like protein is involved in regulation of mitochondrial and flagellar functions as well as in intramacrophage survival of Leishmania donovani

Singh, Kuldeep; Veluru, N K; Trivedi, Vishal; Gupta, C M; Sahasrabuddhe, A A (2014)

Actin related proteins are ubiquitous actin-like proteins that show high similarity with actin in terms of their amino acid sequence and three-dimensional structure. However, in lower eukaryotes, such as trypanosomatids, ...
Triazino indole-Quinoline hybrid: A novel approach to Antileishmanial agents

Sharma, Rashmi; Pandey, A K; Shivahare, Rahul; Srivastava, Khushboo; Gupta, Suman; Chauhan, P M S (2014)

A novel series of 1,2,4-triazino-[5,6b]indole-3-thione covalently linked to 7-chloro-4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular ...
Synthesis of polyhydroxylated indolizidines and piperidines from Garner’s aldehyde: Total synthesis of (-)-Swainsonine, (+)-1,2-Di-epi-swainsonine, (+)-8,8a-Di-epi-castanospermine, Pentahydroxy Indolizidines, (-)-1-Deoxynojirimycin, (-)-1-Deoxy-altro-nojirimycin and related diversity

Singh, Priyanka; Manna, S K; Panda, Gautam (2014)

Diastereoselective and diverse synthesis of polyhydroxylated indolizidines and piperidines have been described, where a common chiral intermediate 2-(hydroxymethyl) piperidine-3-ol is converted into (-)-Swainsonine, ...
miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation

Kureel, J.; Dixit, M.; Tyagi, A M; Mansoori, M N; Srivastava, K; Raghuvanshi, A; Maurya, R; Trivedi, R; Goel, A; Singh, Divya (2014)

MicroRNAs (miRNAs) are short non-coding RNAs that interfere with translation of specific target mRNAs and thereby regulate diverse biological processes. Recent studies have suggested that miRNAs might play a role in ...
Modulation of host’s immune responses and parasite load in Mastomys coucha immunized with recombinant mitochondrial HSP60 of human lymphatic filarial parasite Brugia malayi

Verma, A K; Verma, S K; Kushwaha, Vikas; Verma, Richa; Siddiqui, W A; Murthy, P K (2013)

Recently we have shown that mitochondrial HSP60 of Brugia malayi (mtHSP60bm) shows high degree of homology with Escherichia coli GroEL/ES and that the ATP binding pockets of HSP60 in humans, E. coli and B. malayi were ...
Combining a synthetic spermicide with a natural trichomonacide for safe, prophylactic contraception

Jain, Ashish; Kumar, Lokesh; Kushwaha, Bhavana; Sharma, Monika; Pandey, Aastha; Verma, Vikas; Sharma, Vikas; Singh, Vishal; Rawat, Tara; Sharma, V L; Maikhuri, J P; Gupta, Gopal (2014)

Study question: Can a specifically acting synthetic spermicide (DSE-37) be combined with a natural microbicide (saponins) for safe, prophylactic contraception? Summary answer: A 1:1 (w/w) combination of DSE-37 and Sapindus ...

Now showing items 281-300 of 1093

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