CSIR-CDRI Publications: Recent submissions

Now showing items 101-120 of 1093

Curcuma Oil ameliorates insulin resistance and associated thrombotic complications in hamster and rat

Singh, Vishal; Jain, Manish; Misra, Ankita; Khanna, Vivek; Prakash, Prem; Malasoni, Richa; Dwivedi, A K; Dikshit, Madhu; Barthwal, M K (2015)

Background and objectives: Curcuma Oil (C. Oil) isolated from Turmeric (Curcuma longa L.) has shown neuroprotective, anti-cancer, anti-oxidant and anti-hyperlipidemic effect in experimental animal models, yet its effect ...
Antidiabetic and Antidyslipidemic Activity of Ethyl Acetate Fractions Xylocarpus Granatum and Xylocarpus Molluccensis on High Fructose High Fat and High Sucrose High Fat Fed-Low Dosed Streptozotocin Treated Diabetic Rats

Srivastava, S P; Mishra, Akansha; Lakshmi, Vijai; Tamrakar, A K; Srivastava, M N; Srivastava, A K (2015)

Objectives: The present study was carried out to investigate the antidiabetic and antidyslipidemic effect of standardized fractions of X. granatum (CDR-134 F194) and X. molluccensis (CDR-267F018) by measuring the status ...
4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway

Rawat, A K; Korthikunta, Venkateswarlu; Gautam, Sudeep; Pal, Savita; Tadigoppula, Narender; Tamrakar, A K; Srivastava, A K (2014)

4-Hydroxyisoleucine (4-HIL) is an unusual amino acid isolated from Fenugreek seeds (Trigonella foenum graecum L). Various studies have shown that it acts as an antidiabetic agent yet its mechanism of action is not clear. ...
Functionalized Biaryls as Potent Antihyperglycemic Agents: Synthesis, Molecular Modeling and Biological Evaluation

Goel, Atul; Nag, Pankaj; Rahuja, Neha; Srivastava, Rohit; Chaurasia, Sumit; Gautam, Sudeep; Chandra, Sharat; Siddiqi, M I; Srivastava, A K (2014)

A novel series of functionalized biaryls was designed and synthesized using ketene-S,S-acetal as useful synthon followed by carbanion-induced ring transformation of functionalized lactones. Among various synthesized ...
Molecular Iodine Catalysed One-Pot Synthesis of Chromeno[4,3-b]quinolin-6-ones under Microwave Irradiation

Sashidhara, K V; Palnati, G R; Singh, L R; Upadhyay, Amit; Avula, S R; Kumar, Abdhesh; Kant, Ruchir (2015)

We demonstrate a facile one pot approach for the regioselective synthesis of chromeno[4,3-b] quinoline derivatives in excellent yields under microwave (MW) irradiation. This transformation presumably proceeds via a ...
Identification of Novel Inhibitors of Mycobacterium tuberculosis PknG using Pharmacophore based Virtual Screening, Docking, Molecular Dynamics Simulation and their Biological Evaluation

Nidhi, Singh; Tiwari, Sameer; Srivastava, K K; Siddiqi, M I (2015)

PknG is a Ser/thr protein kinase that plays crucial role in regulatory processes within mycobacterial cell and signalling cascade of infected host cell. Essentiality of PknG in mycobacterial virulence by blocking ...
Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice

Dwivedi, Pankaj; Khatik, Renuka; Khandelwal, Kiran; Srivastava, Richa; Taneja, Isha; Raju, K S R; Dwivedi, Hemlata; Shukla, Prashant; Gupta, Pramod; Singh, Sarika; Tripathi, Renu; Paliwal, S K; Wahajuddin; Dwivedi, A K; Mishra, P R (2014)

Objective: The aim of the study was to develop oral arteether (AE) nano formulations and to investigate its effects in rats; for complete and effective treatment of Plasmodium yoelii nigeriensis infected mice at reduced ...
Reinvestigations into synthesis of allyldithiocarbamates and their intramolecular cyclization: Synthesis and antihyperglycemic activity of 2-thioxothiazolidine-4-alkanoates

Dighe, S U; Yadav, V D; Srivastava, Rohit; Mishra, Akanksha; Gautam, Sudeep; Srivastava, A K; Balaramnavar, V M; Saxena, A K; Batra, Sanjay (2014-09-23)

Reinvestigating the synthesis of allylthiocarbamates from MBH derivatives revealed that they are obtained more efficiently from allylbromides in isopropanol rather than acetates in water. Further unlike reported, the ...
Significant association of metabolic indices, lipid profile, and androgens levels with prostate cancer

Tewari, Reshu; Chhabra, Mohini; Natu, S M; Goel, Apul; Dalela, Divakar; Goel, M M; Singh, Rajender (2014)

Aim: To compare the levels of metabolic indices, lipid profile, androgens, and prostate specific antigen between prostate cancer and BPH and between the grades of prostate cancer in a cross-sectional study. Materials and ...
Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells

Jaiswal, Natasha; Gunaganti, Naresh; Maurya, C K; Narender, Tadigoppula; Tamrakar, A K (2015)

Elevated fatty acid levels play pathogenic role in the development of insulin resistance, associated with type 2 diabetes. Interventions with ability to ameliorate fatty acid-induced insulin resistance might be useful for ...
The prophage encoded hyaluronate lyase has broad substrate specificity and regulated by the N-terminal domain

Singh, S K; Bharati, A P; Singh, Neha; Pandey, Praveen; Joshi, Pankaj; Singh, Kavita; Mitra, Kalyan; Gayen, J R; Sarkar, Jayanta; Akhtar, M S (2014)

Streptococcus equi (S. equi) is the causative agent of the highly contagious disease ‘strangles’ in equines and zoonotic meningitis in human. Spreading of infection in host tissues is thought to be facilitated by the ...
Ida-1, the Caenorhabditis elegans Orthologue of Mammalian Diabetes Autoantigen IA-2, Potentially Acts as a Common Modulator between Parkinson’s Disease and Diabetes: Role of Daf-2/Daf-16 Insulin Like Signalling Pathway

Fatima, Soobiya; Haque, Rizwanul; Jadiya, Pooja; Shamsuzzama; Kumar, Lalit; Nazir, Aamir (2014)

The lack of cure to age associated Parkinson’s disease (PD) has been challenging the efforts of researchers as well as health care providers. Recent evidences suggest that diabetic patients tend to show a higher future ...
Synthesis, 1H NMR and X-ray crystallographic studies of three isomeric butylidene linker protophanes

Avasthi, Kamlakar; Shukla, Lakshmi; Kant, Ruchir (2014)

In this study, the synthesis of isomeric butylidene linker protophanes by the reaction of butylidene linker bis-lactam with n-propyl iodide in K2CO3/DMF is reported. All the three isomers showed folded (syn) conformation ...
Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity

Sashidhara, K V; Modukuri, R K; Singh, Seema; Rao, K B; Teja, G A; Gupta, Sampa; Shukla, Shubha (2015)

A new series of coumarin based aminopyran derivatives were designed, synthesized and evaluated for their preclinical antidepressant effect on Swiss albino mice. Among the series, compounds 21, 25, 26, 27, 32 and 33 exhibited ...
Synthesis of the pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4

Mandal, P K (2014)

The pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4 strainhas been synthesizedusing a combination of sequential glycosylations and [3+2] block synthetic strategyfrom the suitably protected monosaccharide ...
Regioselective Metal-free Decarboxylative Multicomponent Coupling of -Amino acids, Aldehydes and Isonitriles leading to N-substituted azacyclic-2-carboxamideswith Antithrombotic activity

Dighe, S U; Kumar, A K S; Srivastava, Smriti; Shukla, Pankaj; Singh, Surendra; Dikshit, Madhu; Batra, Sanjay (2015)

An atom-economical regioselective synthesis of N-substituted prolinamides or N-substituted pirperidine-2-carboxamides via a metal-free decarboxylative multicomponent coupling between L-proline or pipecolic acid, aldehydes ...
Total synthesis of 3-epi-(+)-lycoricidine from Garner aldehyde via intramolecular aldol cyclization

Bera, Saurav; Das, S K; Saha, Tiash; Panda, Gautam (2015)

A highly efficient total synthesis of 3-epi-(+)-lycoricidine has been described for the first time from easily available (S)-Garner aldehyde with an overall yield of 7% in 20 steps. Stereoselective nucleophilic addition, ...
Novel β-carboline-quinazolinone hybrid as inhibitor of Leishmania donovani Trypanothione Reductase: Synthesis, molecular docking and bioevaluation

Chauhan, S S; Pandey, Shashi; Shivahare, Rahul; Ramalingam, Karthik; Krishna, Shagun; Vishwakarma, Preeti; Siddiqi, M I; Gupta, Suman; Goyal, Neena; Chauhan, P M S (2015)

Trypanothione reductase (TR) is a vital enzyme in the trypanothione based redox metabolism of trypanosomatid parasites. It is one of only a handful number of chemically validated targets for Leishmania. Herein, we report ...
4-Aminoquinoline-Schiff base Hybrid: Rational Drug Design Approach for Overcoming Chloroquine Resistance in Malaria

Sharma, Rashmi; Pandey, A K; Srivastava, Kumkum; Puri, S K; Singh, S V; Saxena, J K; Chauhan, P M S (2014)

Antimalarials based on the 4-aminoquinoline-schiff base hybrid coupled with oxalamide functionality as linker are designed and synthesized. The molecules were evaluated for their antiplasmodial activity against ...
Quantitative Analysis of Bioactive Carbazole Alkaloids in Murraya koenigii

Joshi, Trapti; Mahar, Rohit; Singh, S K; Srivastava, Piush; Shukla, S K; Mishra, D K; Bhatta, R S; Kanojiya, Sanjeev (2015)

Carbazole alkaloids induce apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway and they are targeted as potential anticancer agents. Thus, the naturally occurring carbazole alkaloids become ...

Now showing items 101-120 of 1093

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