CSIR-CDRI Publications: Recent submissions

Now showing items 121-140 of 1093

Amphiphile catalysed selective synthesis of 4-Amino alkylated-1H-pyrazol-5-ol via Mannich-aromatization prefer over Knoevenagel-Michael type reaction in water

Kumar, Atul; Maurya, Shivam; Gupta, M K; Shukla, R D (2014)

An economic and efficient amphiphile (SDS) catalysed one pot synthesis of the aromatized 4-amino alkylated-1H-pyrazol-5-ol via a Mannich type reaction that is preferable compared to a Knoevenagel–Michael type reaction, ...
Molecular insights of protein contours recognition with ligand pharmacophoric sites through combinatorial library design and MD simulation in validating HTLV-1 PR inhibitors

Selvaraj, Chandrabose; Omer, Ankur; Singh, Poonam; Singh, S K (2015)

In Retroviruses HIV-1 and HTLV-1 are most dangerous pathogens, which cause much damage to the Homo sapiens. Both viruses are having protease enzyme which common for its replication mechanism besides its structural unique ...
Targeting of Gastrointestinal Tract for Amended Delivery of Proteins/Peptides Therapeutics: Strategies and Industrial Perspectives

Pawar, V K; Meher, J G; Singh, Yuvraj; Chaurasia, Mohini; Reddy, B S; Chourasia, M K (2014)

Delivery of proteins/peptides in gastrointestinal (GI) tract via peroral/oral route involves tremendous challenges due to unfavorable environmental conditions like harsh pH, presence of proteolytic enzymes and absorption ...
Identification of quinoline-chalcone hybrids as potential antiulcer agents

Sashidhara, K V; Avula, S R; Mishra, Vaibhav; Palnati, G R; Singh, L R; Singh, Neetu; Chhonker, Y S; Swami, Priyanka; Bhatta, R S; Palit, Gautam (2015)

Antiulcer activity of novel quinoline-chalcone hybrids (13-37) was investigated. Among them, eight compounds (14, 16, 17, 23, 29, 31, 32 and 35) were found to be active in various ulcer models in Sprague-Dawley (SD) rats. ...
Immunotherapeutic Vitamin E Nanoemulsion Synergies the Antiproliferative Activity of Paclitaxel in Breast Cancer Cells via Modulating Th1 and Th2 Immune Response

Pawar, V K; Panchal, S B; Singh, Yuvraj; Meher, J G; Sharma, Komal; Singh, Pankaj; Bora, H K; Singh, Akhilesh; Datta, Dipak; Chourasia, M K (2014)

Paclitaxel (PTX) is used as first line treatment for metastatic breast cancer but the relief comes at a heavy cost in terms of accompanying adverse effects. The pharmaceutical credentials of PTX are further dampened by the ...
Chemical and Medicinal Versatility of Dithiocarbamates: An Overview

Bala, Veenu; Gupta, Gopal; Sharma, V L (2014)

Dithiocarbamates are considered as the simplest occurring organosulfur compounds exhibiting diverse chemical and medicinal versatility. Dithiocarbamates have been used as pesticide in the 20th century but thereafter they ...
Nitroimidazo-oxazole Compound (DNDI-VL-2098) - An Orally Effective Preclinical Drug Candidate for the Treatment of Visceral Leishmaniasis

Gupta, Suman; Yardley, Vanessa; Vishwakarma, Preeti; Shivahare, Rahul; Sharma, Bhawna; Launay, Delphine; Martin, Denis; Puri, S K (2015)

Objective: Identification of a nitroimidazo-oxazole lead molecule for the treatment of visceral leishmaniasis (VL). Methods: A library of 72 nitroimidazo-oxazoles was evaluated in vitro for their antileishmanial activity ...
Curcumal Oil Attenuates Accelerated Atherosclerosis and Macrophage Foam Cell Formation by Modulating Genes Involved in Plaque Stability, Lipid Homeostasis and Inflammation

Singh, Vishal; Rana, Minakshi; Jain, Manish; Singh, Niharika; Naqvi, Arshi; Malasoni, Richa; Dwivedi, A K; Dikshit, Madhu; Barthwal, M K (2015)

In the present study, the anti-atherosclerotic effect and underlying mechanism of curcuma oil (C.oil), a lipophilic fraction from turmeric (Curcuma longa L.), was evaluated in a hamster model of accelerated atherosclerosis ...
Moxifloxacin Loaded Nanoemulsions having Tocopheryl Succinate as Integral Component Improves Pharmacokinetics and Enhances Survival in E Coli Induced Complicated Intra-Abdominal Infection

Shukla, Prashant; Verma, A K; Dwivedi, Pankaj; Yadav, Arti; Gupta, P K; Rath, S K; Mishra, P R (2014)

In the present work a novel nanoemulsion laden with moxifloxacin has been developed for effective management ofcomplicated Intra-abdominal infections.Moxifloxacin nanoemulsion fabricated using high pressure homogenization ...
Time Course of the Changes in Novel Trioxane Antimalarial 99/411 Pharmacokinetics upon Antiepileptic Drugs co-administration in SD Rats

Singh, Yeshwant; Kushwaha, H N; Misra, Anamika; Hidau, M K; Singh, S K (2014)

Objective: The study aimed to evaluate the influences of co-administration of antiepileptic drugs (AEDs) on an anti-malarial candidate 99/411 pharmacokinetic (PK) profile. Method: For this, single oral dose PK drug ...
In vitro Anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives

Korthikunta, Venkateswarlu; Pandey, Jyotsana; Singh, Rohit; Srivastava, Rohit; Srivastava, A K; Tamrakar, A K; Tadigoppula, Narender (2015)

The nonproteinogenic amino acid, 4-hydroxyisoleucine (1) has been isolated in large quantities from the fenugreek (T. foenum-graecum) seeds. Few novel derivatives (3-11 and 13-18) were prepared from the naturally occurring ...
Identification of novel inhibitors of human Chk1 using pharmacophore-based virtual screening and their evaluation as potential anti-cancer agents

Kumar, Vikash; Khan, Saman; Gupta, Priyanka; Rastogi, Namrata; Mishra, D P; Ahmed, Shakil; Siddiqi, M I (2014)

Kinases are one of the major players in cancer development and progression. Serine threonine kinases such as human checkpoint kinase-1(Chk1), Mek1 and cyclin-dependent kinases (CDKs) have been identified as promising targets ...
Design, synthesis and molecular docking of substituted 3-hydrazinyl-3-oxo-propanamides as anti-tubercular agents

Naqvi, Arshi; Malasoni, Richa; Srivastava, Akansha; Pandey, R R; Dwivedi, A K (2014)

Based on the anti-mycobacterial activity of various acid hydrazides, a series of substituted 3-hydrazinyl-3-oxo-propanamides has been designed. The target compounds have been synthesized from diethylmalonate using substituted ...
Alteration in endometrial proteins during early- and mid-secretory phases of the cycle in women with unexplained infertility

Manohar, Murli; Khan, Huma; Sirohi, V K; Das, Vinita; Agarwal, Anjoo; Pandey, Amita; Siddiqui, W A; Dwivedi, Anila (2014)

Background: Compromised receptivity of the endometrium is a major cause of unexplained infertility, implantation failure and subclinical pregnancy loss. In order to investigate the changes in endometrial protein profile ...
Chemotherapy of leishmaniasis part XIII: Design and synthesis of novel heteroretinoid-bisbenzylidine ketone hybrids as antileishmanial agents

Tiwari, Avinash; Kumar, Santosh; Shivahare, Rahul; Kant, Padam; Gupta, Suman; Suryawanshi, S N (2015)

Some novel heteroretinoid-bisbenzylidine ketone hybrids have been synthesized and evaluated for their in vitro antileishmanial activity against intramacrophagic amastigotes of Leishmania donovani. Among all the nine ...
Solution Structures and Dynamics of ADF/cofilinsUNC-60A and UNC-60B from Caenorhabditiselegans

Shukla, V K; Kabra, Ashish; Maheshwari, Diva; Yadav, Rahul; Jain, Anupam; Tripathi, Sarita; Ono, Shoichiro; Kumar, Dinesh; Arora, Ashish (2015)

The nematode Caenorhabditiselegans has two ADF/cofilin isoforms, UNC-60A and UNC-60B, which are expressed from theunc60 gene by alternative splicing.UNC-60A has higher activity to cause net depolymerization, and to inhibit ...
Synthesis of Fluorescent C2-Bridged Teraryls and Quateraryls for Blue, Skyblue and Green Color Light Emitting Devices

Goel, Atul; Sharma, Ashutosh; Rawat, Madhu; Anand, R S; Kant, Ruchir (2014)

Highly fluorescent, stable blue, skyblue and green color light emitting teraryls and quateraryls were prepared from a ketene-S,S-acetal under mild conditions. These compounds exhibited photoluminescence both in solid state ...
Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application

Chhonker, Y S; Prasad, Y D; Chandasana, Hardik; Vishvkarma, Akhilesh; Mitra, Kalyan; Shukla, P K; Bhatta, R S (2015)

Fungal keratitis is the major cause of vision loss worldwide. Amphotericin-B is considered as the drug of choice for fungal infections. However, its use in ophthalmic drug delivery is limited by the low precorneal residence ...
Osteogenic activity of natural diterpenoids in calvarial derived osteoblast cells via differentiation and mineralization

Khan, M F; Dev, Kapil; Lahiri, Shibani; Dixit, Manisha; Trivedi, Ritu; Singh, Divya; Maurya, Rakesh (2014)

The aim of the present study was to investigate the antiosteoporotic activity of four structurally related diterpenoids: sugiol (1), trans-communic acid (2), 15-acetoxy imbricatolic acid (3) and imbricatolic acid (4). Their ...
Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity

Thakur, R K; Mishra, Akansha; Ramakrishna, K K G; Mahar, Rohit; Shukla, S K; Srivastava, A K; Tripathi, R P (2014)

A series of novel nucleoside analogues having dual bases (pyrimidine and triazole) and sugars have been synthesized by CuAAC reaction of azido sugars with propynylated pyrimidines. These compounds were evaluated for their ...

Now showing items 121-140 of 1093

Search DSpace

Advanced Search

Browse

All of DSpace
This Community
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

CSIR-CDRI Publications: Recent submissions

Search DSpace

Browse

All of DSpace

This Community

My Account