CSIR-CDRI Publications: Recent submissions

Now showing items 81-100 of 1093

A twinfilin-like protein coordinates karyokinesis by influencing mitotic spindle elongation and DNA replication in Leishmania

Kumar, Gaurav; Kajuluri, L P; Gupta, C M; Sahasrabuddhe, A A (2016)

Twinfilin is an evolutionarily conserved actin-binding protein, which regulates actin-dynamics in eukaryotic cells. Homologs of this protein have been detected in the genome of various protozoan parasites causing diseases ...
EVALUATION OF ANTIDYSLIPIDEMIC EFFECT OF MANGIFERIN AND AMAROGENTIN FROM SWERTIA CHIRAYITA EXTRACT IN HFD INDUCED CHARLES FOSTER RAT MODEL AND THEIR DOCKING STUDIES

Asthana, R K; Gupta, Rasna; Agrawal, Nidhi; Srivastava, Atul; Chaturvedi, Upma; Kannojiya, Sanjeev; Khanna, A K; Bhatia, Gitika; Sharma, V L (2014)

In continuation of our research programs on bio evaluation of medicinal plants in India, we have investigated antidyslipidemic and antioxidant potential of Swertia chirayita (SC) plant, a potent antidiabetic and its ...
Linearization of carbohydrate derived polycyclic frameworks

Singh, Priyanka; Panda, Gautam (2014)

We report an easy access to carbohydrate derived diverse tricyclic skeletons which could be beneficial for exploring polyfunctionalized chiral alicycles. The key reaction to assemble sugar fused tricyclic core is intermolecular ...
Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I

Yadav, Nisha; Khanam, Taran; Shukla, Ankita; Rai, Niyati; Hajela, Kanchan; Ramachandran, Ravishankar (2015)

DNA ligases are critical players of DNA metabolism in all organisms. NAD+-dependent DNA ligases (LigA) found exclusively in bacteria and certain entomopoxviruses are drawing increasing attention as therapeutic targets as ...
Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6- Gingerol in cervical cancer cells

Rastogi, Namrata; Duggal, Shivali; Singh, S K; Porwal, Konica; Srivastava, V K; Maurya, Rakesh; Bhatt, M L B; Mishra, D P (2015)

Human papilloma virus (HPV) expressing E6 and E7 oncoproteins, is known to inactivate the tumor suppressor p53 through proteasomal degradation in cervical cancers. Hence, a possible approach to p53 reactivation and induction ...
Sulphur mobilisation for [Fe-S] cluster assembly by the essential SUF pathway in the Plasmodium falciparum apicoplast and its inhibition

Charan, Manish; Nidhi; Kumar, Bijay; Srivastava, Kumkum; Siddiqi, M I; Habib, Saman (2014)

The plastid of the malaria parasite- the apicoplast is essential for parasite survival. It houses several pathways of bacterial origin that are considered as attractive sites for drug intervention. Among these is the SUF ...
A Rapid Analytical Method for Characterization and Simultaneous Quantitative Determination of Phytoconstituents in Piper betle landraces Using UPLC-ESI-MS/MS

Pandey, Renu; Chandra, Preeti; Srivastva, Mukesh; Arya, K R; Shukla, P K; Kumar, Brijesh (2014)

A rapid ultra performance liquid chromatography electrospray ionisation tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed and validated for identification and characterization of phytoconstituents with ...
Facile ligand-free Pd-catalyzed tandem C-C/C-N coupling reaction: A novel access to highly diverse tetrazole tag isoindoline derivatives

Sharma, Moni; Khan, Irfan; Khan, Shahnawaz; Mahar, Rohit; Shukla, S K; Kant, Ruchir; Chauhan, P M S (2015)

A novel and robust route for the synthesis of diversely substituted isoindoline skeletons through ligand-free Pd-catalyzed cascade consisting of isocyanide insertion into Ugi-tetrazole has been developed. The tetrazole ...
Curcumin Affords Protection against Valproic Acid Induced Teratogenicity by Curtailing Oxidative Stress and Inhibiting CYP2C9 activity

Kumar, Akhilesh; Chandasana, Hardik; Bhatta, R S; Sethi, Nikunj; Yadav, Sudhaker; Sinha, Neeraj (2015)

Administration of drugs during pregnancy is always done with immense caution however, multiple neurological ailments including epilepsy and depression warrant medical treatments even during pregnancy. This exposes unborn ...
Substrate-controlled product-selectivity in the reaction of Bestmann-Ohira reagent with N-unprotected isatin-derived olefins

Gupta, A K; Ahamad, Shakir; Gupta, Ekta; Kant, Ruchir; Mohanan, Kishor (2015)

A mild and efficient reaction of Bestmann-Ohira reagent with N-unprotected isatin-derived olefins has been developed for the selective synthesis of spiro-pyrazoline-oxindoles and tricyclic pyrazoles. The reaction features ...
Novel Glycoconjugate of 8-Fluoro Norfloxacin Derivativesas Gentamycin Resistant Staphylococcus aureus Inhibitors: Synthesis and Molecular Modeling Studies

Azad, C S; Bhunia, S S; Krishna, Atul; Shukla, P K; Saxena, A K (2015)

Antibiotic resistance has been the subject of interest in clinical practice due to high prevalence of antibiotic-resistant pathogenic organisms. In view of the prevalence of lesser resistance in antibiotics belonging to ...
Immunological evaluation of an rsmD-like rRNA methyltransferase from Wolbachia endosymbiont of Brugia malayi

Rana, A K; Kushwaha, Susheela; Singh, P K; Bhattacharya-Misra, Shailja (2016)

Wolbachia is a wonderful anti-filarial target with many of its enzymes and surface proteins (WSPs) representing potential drug targets and vaccine candidates. Here we report on the immunologic response of a drug target, ...
Pharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits

Saxena, Amrita; Valicherlaa, G R; Joshi, Pankaj; Saxena, Rohit; Cheruvu, S H; Bhunia, S S; Jain, G K; Siddiqui, H H; Saxena, A K; Gayen, J R (2015)

1. S002-333 [(2-(4'-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-pyrido (3,4-b) indole-3-carboxylic acid amide)] is a novel and potent antithrombotic active agent. The present work investigates the pharmacokinetics, ...
Copper-catalyzed highly efficient oxidative amidation of aldehydes with 2-aminopyridines in an aqueous micellar system

Patel, O P S; Anand, Devireddy; Maurya, R K; Yadav, P P (2015)

An environmentally benign and atom economical protocol has been developed for the synthesis of N-(pyridine-2-yl)amides from aldehydes and 2-aminopyridines under mild condition. This approach required Cu(OTf)2 as a catalyst, ...
9-Demethoxy-medicarpin promotes peak bone mass achievement and has bone conserving effect in ovariectomized mice: positively regulates osteoblast functions and suppresses osteoclastogenesis

Goel, Atul; Raghuvanshi, Ashutosh; Kumar, Amit; Gautam, Abnish; Srivastava, Kamini; Kureel, Jyoti; Singh, Divya (2015)

We report a new bone anabolic and anti-catabolic pterocarpan 9-demethoxy-medicarpin (DMM) for the management of postmenopausal osteoporosis. DMM promoted osteoblast functions via activation of P38MAPK/BMP-2 pathway and ...
Isocitrate lyase of Mycobacterium tuberculosis is inhibited by quercetin through binding at N-terminus

Shukla, Harish; Kumar, Vikash; Singh, A K; Rastogi, Shivangi; Khan, S R; Siddiqi, M I; Krishnan, M Y; Akhtar, M S (2015)

Combating tuberculosis requires new therapeutic strategies that not only target the actively dividing bacilli but also the dormant bacilli during persistent infection. Isocitrate lyase (ICL) is a key enzyme of the glyoxylate ...
Sensitive and high-throughput bioanalysis of fluoxetine and nor-fluoxetine in rabbit and human plasma using SPE-LC-MS/MS

Prasad, Y D; Chhonker, Y S; Chandasana, Hardik; Laxman, T S; Bala, Veenu; Kanojiya, Sanjeev; Ghatak, Sandeep; Bhatta, R S (2015)

Fluoxetine is a commonly prescribed antidepressant agent in psychotherapy. A rapid, selective and sensitive LC-MS/MS method was developed and validated for simultaneous estimation of fluoxetine and its metabolite ...
Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models

Verma, Meenakshi; Pathak, Manisha; Shahab, Mohd; Singh, Kavita; Mitra, Kalyan; Bhattacharya-Misra, Shailja (2014)

Moxidectin is a macrocyclic lactone belonging to milbemycin family closely related to ivermectin and is currently progressing towards Phase III clinical trial against human infection with the filaria Onchocerca volvulus ...
HPLC analytical method for simultaneous estimation of Mefloquine and Clarithromycin

Ahmad, Hafsa; Khandelwal, Kiran; Pachauri, S D; Gunjan, Sarika; Tripathi, Renu; Dwivedi, A K (2014)

Abstract Clarithromycin is a semi-synthetic macrolide anti-biotic exhibiting good antimicrobial activity over erythromycin and mefloquine is an anti-malarial agent against falciparum malaria. Clarithromycin, a cytochrome ...
Do Blood Sampling Sites Affect Pharmacokinetics?

Rangaraj, Nagarjun; Vaghasiya, Kalpesh; Jaiswal, Swati; Sharma, Abhisheak; Shukla, Mahendra; Lal, Jawahar (2014)

Preclinical and clinical pharmacokinetic (PK) profiling is the bottleneck of the drug development process. PK involves assessment of plasma/serum/blood drug concentration at different time points post drug administration. ...

Now showing items 81-100 of 1093

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