Abstract:
Antimalarials based on the 4-aminoquinoline-schiff base hybrid coupled with oxalamide functionality as linker are designed and synthesized. The molecules were evaluated for their antiplasmodial activity against choroquine-resistant (CQ-R) K1 and choroquine-sensitive (CQ-S) 3D7 of Plasmodium falciparum strains. Some of the novel compounds were found to be more potent than Chloroquine in vitro against CQ-R strain. Furthermore several molecules also showed promising β-hematin inhibitory activity.
