Actin related proteins are ubiquitous actin-like proteins that show high similarity with actin in terms of their amino acid sequence and three-dimensional structure. However, in lower eukaryotes, such as trypanosomatids, ...

Structural information on the anhydrous forms of levofloxacin, a broad spectrum fluoroquinolone antibiotic drug is limited as it readily converts into the more stable hemi-hydrate form. Obtaining, single crystals of the ...

The sliding b-clamp, an important component of the DNA replication and repair machinery, is drawing increasing attention as a therapeutic target. We report the crystal structure of the M. tuberculosis b-clamp (Mtbb-clamp) ...

The Molybdenum cofactor (Moco) biosynthesis pathway is an evolutionary conserved pathway seen in almost all eukaryotes including the pathogenic species Mycobacterium tuberculosis. This pathway comprises of several novel ...

Site directed mutagenesis study was performed to elucidate the role of conserved tryptophan-101 present at the active site of phosphoserine aminotransferase from an enteric human parasite Entamoeba histolytica. Fluorescence ...

HIV-1 Nef modulates disease progression through interactions with over 30 host proteins. Individual chains fold into membrane-interacting N-terminal and C-terminal core (Nefcore) domains respectively. Nef exists as small ...

Cytotoxicity, a major obstacle in therapeutic application of antimicrobial peptides, is controlled by leucine zipper like sequences in melittin and other naturally-occurring antimicrobial peptides. Magainin 2 shows ...

Post-translational modifications of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) specify a code that is deciphered by proteins involved in RNA biogenesis. The CTD is comprised ...

Hemolysin E (HlyE), a pore-forming protein-toxin and a potential virulence factor of Escherichia coli, exhibits cytotoxic activity to mammalian cells. However, very little is known about how the different individual ...

Aminophospholipid movements in the plasma membrane of higher eukaryotic cells seem to be regulated by an ATP-dependent, protein-mediated process. To examine whether similar mechanisms exist in yeast cells, we have analysed ...