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Now showing items 1-20 of 83

Intermolecular crosslinking of fatty acyl chains in phospholipids: Use of photoactivable carbene precursors

Gupta, C M; Radhakrishnan, Ramachandran; Gerber, Gerhard E; Olse, William L; Quay, Steven C; Khorana, H Govind (1979)

Phospholipids containing photolysable carhene precursors (beta-trifluoro-a-diazopropionoxy and m-diazirinophenoxy groups) in w-positions of sn-2 fatty acyl chains were prepared. Photolysis of their vesicles produced ...
Sites of intermolecular crosslinking of fatty acyl chains in phospholipids carrying a photoactivable carbene precursor

Gupta, C M; Costello, Catherine E; Khorana, H Govind (1979)

Sonicated vesicles of l-fatty acyl-2-w-(2-diazo-3.3,3-trifluoropropionoxy) fatty acyl sn-glycero-3-phosphorylcholines were shown recently to form intermolecular crosslinks by insertion of the photogenerated carbene into ...
Carbamyl Analogs of Phosphatidylcholines Synthesis, Interaction With Phospholipases and Permeability Behavior of their Liposomes

Gupta, C M; Bali, Anu (1981)

A novel class of phospholipase-resisting phosphatidylcholine analogs, in which the C-2 ester group or both C-1 and C-2 ester groups have been replaced by carbamyloxy functions (-NH-C-O-), have been synthesized. These lipids ...
Involvement of Malarial Proteases in the Interaction between the parasite and host erythrocyte in plasmodium knowlesi infections

Banyal, H S; Misra, G. C.; Gupta, C M; Dutta, G P (1981)

The effect of protease inhibitors obtained from the culture filtrates of actinomycetes(pepstatin, chymostatin, leupeptin, phosphoramidon and elastatinal)on the in vitro inbasion of erythrocytes from rhesus and assanese ...
Transbilayer Phospholipid Asymmetry in Plasmodium knowlesi- Infected Host Cell Membrane

Gupta, C M; Mishra, G C (1981)

The membranes from normal and Plasmodium knowlesi-infected rhemsus monkey erythrocytes (90 to 95 percent infected with early ring stage) were analyzed for transbilayer distribution of phosphatidylcholine (PC). ...
Modification of phospholipid structure results in greater stability of liposomes in Serum

Gupta, C M; Bali, Anu; Dhawan, Subhash (1981)

prevous studies have revealed that the replacement of the C-2 ester group in phoshatidylcholine by the carbamyloxy function renders the resulting lipids, without affecting the properties of the liposomes, resistant to ...
A new look at nonparasitized red cells of malaria-infected monkeys

Gupta, C M; Alam, A; Mathur, P N; Dutta, G P (1982)

Many reports have shown that malarial parasites can produce distinct morphological and molecular alterations in the membranes of the parasitized erythrocytes (l-8), but few studies have been carried out on nonparasitized ...
Effect of Altered Polar Headgroup of Phosphatidylethanolamines on Transbilayer Aminophospholipid Distribution in Sonicated Vesicles

Kumar, Ajay; Gupta, C M (1983)

The transbilayer aminophospholipid distributions in small unilamellar vesicles comprising of phosphatidylethanolamine or its analogs (bearing modifications in the polar headgroup) and egg hosphatidylcholine were ascertained ...
Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component

Bali, Anu; Dhawan, S; Gupta, C M (1983)

Replacement of the C-2 ester group in phosphatidylcholine by the carbamyloxy function rendered its liposomes completely stable and longer living in the circulation of rats.
Red cell membrane abnormalities in chronic myeloid leukaemia

Kumar, Ajay; Gupta, C M (1983)

Chronic myeloid leukaemia (CML) is a clonal neoplasm that arises in a stem cell common to granulocytes and erythrocytes (l-3). Several abnormalities have been identified in the plasma membranes of granulocytes of CML ...
Transbilayer Distributions of Red Cell Membrane Phospholipids in Unilamellar Vesicles

Kumar, Ajay; Gupta, C M (1984)

The phospholipid organization in unilamellar vesicles comprised of various purified phospholipid components of monkey erythrocyte membrane was ascertained using phospholipase A2 and trinitrobenzenesulfonic acid as external ...
Synthesis of Carbamyl and Ether Analogs of Phosphatldylchollnes

Agarwal, Kirti; Bali, Anu; Gupta, C M (1984)

A complete synthesis of I-O-hexadecyl-2-O-N-(heptadec-8-cis-enyl)carbamyl-sn-glycer0-3- phosphocholine. a novel analog of phosphatidylcholine, has been described. Each step is simple to perform and gives the desired ...
Transbilayer Phosphatidylcholine Distributions in Small Unilamellar Sphingomyelin-Phosphatidylcholine Vesicles: Effect of Altered Polar Head Group

Kumar, Ajay; Gupta, C M (1985)

The effect of the altered polar head group of phosphatidylcholine (PC) on its transbilayer distributions in small unilamellar vesicles containing sphingomyelin (SM) was ascertained with phospholipase A2 as the external ...
Protection of mice against Plasmodium berghei infection by a tuftsin derivative

Gupta, C M; Puri, Anju; Jain, Rakesh K; Bali, Anu; Anand, Nitya (1986)

In Plasmodium berghei infections, the mortality rate and parasitacmias were significantly reduced and the mean survival time was considerably enhanced by pretreating the animals with a tuftsin derivative, Thr-Lys- Pro- ...
Antibody-mediated targeting of liposomes to red cells in vivo

Singhal, Arun; Gupta, C M (1986)

Covalent attachment of anti-rat erythrocyte F(ab')2 to liposomes specifically enhanced their binding to rat erythrocytes in vivo and reduced their uptake by the liver. Furthermore, at least 20-30% of the cell-bound liposomes ...
Enhancement in anti-Semliki Forest virus activity of ds RNA by a muramyl dipeptide

George, C X; Jain, Rakesh K; Gupta, C M; Anand, Nitya (1986)

Antiviral activity of an interferon-inducing mycoviral ds RNA against Semliki Forest virus infection was considerably enhanced by N-palmitoylmuramyl-L-alanyl-D-isoglutamine (PMDP), a new muramyl dipeptide. This enhancement ...
Antibody-mediated targeting of Liposomes to erythocytes in whole blood

Singhal, Arun; Bali, Anu; Gupta, C M (1986)

F(ab)2 fragments derived from anti-rat erythocyte antibody or normal rabbit serum lgG were covalently attached to the surface of liposomes of equimolar amounts egg phoshatidylcholine and cholesterol. These liposomes were ...
Membrane phospholipid organization in calcium-loaded human erythrocytes

Chandra, R; Joshi, P C; Bajpai, V K; Gupta, C M (1987)

Intracellular Ca2+ levels in human erythrocytes were increased by incubating them with variable concentrations of Ca2+ in the presence of ionophore A23187. Experiments were done to confirm that the Ca2+ loading did induce ...
An intracellular simian malarial parasite (Plasmodium knowlesi) induces stage-dependent alterations in membrane phospholipid organization of its host erythrocyte

Joshi, Paritosh; Dutta, G P; Gupta, C M (1987)

The membrane phospholipid organization in monkey erythrocytes harbouring different developmental stages of the simian malarial parasite Plasmodium knowlesi was studied using phospholipase A2 from two different sources and ...
Abnormal erythrocyte membrane phospholipid organisation in chronic myeloid leukaemia

Kumar, Ajay; Daniel, S; Agarwal, S S; Gupta, C M (1987)

The membrane phospholipid organisation in the red cells of humans suffering from chronic myeloid leukaemia has been analysed using the amino-group labelling reagent trinitrobenzenesulphonic acid and the nuid-sensing ...

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