Abstract:
Covalent attachment of anti-rat erythrocyte F(ab')2 to liposomes specifically enhanced their binding to rat
erythrocytes in vivo and reduced their uptake by the liver. Furthermore, at least 20-30% of the cell-bound
liposomes delivered their contents to the cells. Besides, the liposome binding did not affect the survival time
of the target cells at least up to 3 h in the blood circulation. These results demonstrate for the first time
that liposomes can be successfully targeted to cells other than liver cells in vivo.
