Antibody-mediated targeting of liposomes to red cells in vivo

Singhal, Arun; Gupta, C M

dc.contributor.author	Singhal, Arun
dc.contributor.author	Gupta, C M
dc.date.accessioned	2008-03-26T07:37:48Z
dc.date.available	2008-03-26T07:37:48Z
dc.date.issued	1986
dc.identifier.citation	FEBS Letters (1986), 201, 321-326	en
dc.identifier.uri	http://hdl.handle.net/123456789/126
dc.description.abstract	Covalent attachment of anti-rat erythrocyte F(ab')2 to liposomes specifically enhanced their binding to rat erythrocytes in vivo and reduced their uptake by the liver. Furthermore, at least 20-30% of the cell-bound liposomes delivered their contents to the cells. Besides, the liposome binding did not affect the survival time of the target cells at least up to 3 h in the blood circulation. These results demonstrate for the first time that liposomes can be successfully targeted to cells other than liver cells in vivo.	en
dc.format.extent	2314844 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 3847	en
dc.subject	Drug targeting	en
dc.subject	Liposome	en
dc.subject	Cell-specific antibody	en
dc.subject	F( ab') 2 fragment	en
dc.subject	Erythrocyte	en
dc.title	Antibody-mediated targeting of liposomes to red cells in vivo	en
dc.type	Article	en