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Now showing items 861-880 of 1288

Versatile synthesis of 2-(substituted)phenyl-6,7-dihydro-1H-indol-4(5H)-ones from MBH acetates of 2-oxo-(substituted)phenyl acetaldehydes§

Harikrishna, B; Batra, Sanjay (2012)

A versatile synthesis of 2-(substituted)phenyl-6,7-dihydro-1H-indol-4(5H)-ones from adducts of the Morita-Baylis-Hillman reaction between 2-oxo-(substituted)phenylacetaldehydes and cyclohex-2-enone under mild conditions ...
Industrial Perspective of Gastroretentive Drug Delivery Systems: Physiochemical, Biopharmaceutical, Technological and Regulatory Consideration

Pawar, V K; Kansal, Shaswat; Asthana, Shalini; Chourasia, M K (2012)

Introduction: Concerning patient compliance, oral route is the most promising drug delivery route. Gastroretentive drug delivery systems (GRDDS) can overcome drawbacks associated with oral drug delivery by defeating natural ...
In-vitro and in-vivo antifilarial potential of marine sponge, Haliclona exigua (Kirkpatrick) against human lymphatic filarial parasite Brugia malayi

Lakshmi, Vijay; Srivastava, Shishir; Mishra, S K; Misra, Sweta; Verma, Meenakshi; Bhattacharya-Misra, Shailja (2009)

The present study reports on the antifilarial activity of a marine sponge Haliclona exigua (phylum-Porifera). The crude methanol extract and n-butanol soluble fraction killed adult B. malayi at 31.25μg/ml concentration ...
A New Synthesis of γ-Butyrolactones via AuCl3 or Hg (II)-Catalyzed Intramolecular Hydroalkoxylation of 4-Bromo-3-yn-1-ols†

Reddy, M S; Kumar, Y K; Thirupathi, Nuligonda (2012)

The article describes an efficient conversion of 4-bromo-3-yn-1-ols to γ-butyrolactones via AuCl3 catalyzed electrophilic cyclization (hydroxyl assisted regioselective hydration) in wet toluene. Various 2o and 3o alcohols ...
A radical mediated approach to the stereoselective formal total synthesis of (+)-Sch 642305

Chakraborty, Tushar Kanti; Samanta, Rajarshi; Pulukuri, K K (2009)

Abstract – A formal total synthesis of (+)-Sch-642305 is described. The synthesis, which commenced from a simple chiral synthon (5S)-5-(hydroxymethyl)dihydrofuran-2(3H)-one, employed, as a key step, a radical mediated ...
Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to Rhesus macaques

Verma, R K; Mukker, J K; Singh, R S P; Kumar, Kaushlendra; Verma, P R P; Misra, Amit (2012)

Dry powder inhalations (DPI) of microparticles containing isoniazid (INH) and rifabutin (RFB) are under preclinical development for use in pulmonary tuberculosis. Microparticles containing 0.25, 2.5 or 25 mg of each drug ...
Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer†

Kumar, Shailesh; Deshpande, Shreekant; Kitchlu, Shakti; Chandra, Vishal; Dwivedi, Anila; Nayak, V L; Konwar, Rituraj; Prabhakar, Y S; Sahu, D P (2009)

A novel class of 2,3,4-triarylbenzopyrans has been synthesized and were evaluated for their selective estrogen receptor rmodulation and anti-proliferative activities. 10a and 11c exhibited 73.91 and 69.24 % inhibition as ...
ANTIDYSLIPIDEMIC AND ANTIOXIDANT ACTIVITY OF PINUS ROXBERGHII NEEDLES

Puri, Anju; Srivastava, A K; Singhal, Barkha; Mishra, S K; Srivastava, S; Lakshmi, Vijay (2009)

Pinus roxburghii commonly known as Chir pine contains a substance turpene in abundance and is known for several medicinal properties. The needles were investigated for antidyslipidemic activity in high fat diet (HFD) fed ...
A functionally active dimer of Mycobacterium tuberculosis Malate synthase G

Kumar, Ranjeet; Bhakuni, Vinod (2010)

Malate synthase G an important housekeeping enzyme of glyoxylate shunt in mycobacterium tuberculosis is involved in persistence. The pleotropicity in its function is enigmatic acting as adhesins, virulence factor and being ...
Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson’s disease

Jadiya, Pooja; Khan, Asif; Sammi, Shreesh Raj; Kaur, Supinder; Mir, Snober S; Nazir, Aamir (2011)

Neurodegenerative Parkinson’s Disease (PD) is associated with aggregation of protein alpha synuclein and selective death of dopaminergic neurons, thereby leading to cognitive and motor impairment in patients. The disease ...
Clarithromycin, a cytochrome P450 inhibitor, can reverse mefloquine resistance in Plasmodium yoelii nigeriensis infected Swiss mice

Tripathi, Renu; Pandey, S K; Rizvi, A (2011)

During the last 2 decades there have been numerous reports of the emergence of mefloquine resistance in Southeast Asia and nearly 50% resistance is reported in Thailand. A World Health Organization report (2001) considers ...
Role of Arene Interactions and Substituents Effect in Conformational (syn/anti) Control of 1,2-Diarylethanes†‡

Avasthi, Kamlakar; Kumar, Amar; Aswal, Sangeeta; Kant, Ruchir; Raghunandan, Resmi; Maulik, P R; Khanna, R S; Ravikumar, Krishnan (2012)

Conformational analysis of nine designed flexible 1,2-diarylethanes with different substituents show syn conformation due to π–π interactions by 1H NMR in solution, this carries over to the solid state for three compounds ...
Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4–aminoquinoline with potent antiplasmodial activity

Sunduru, Naresh; Sharma, Moni; Srivastava, Kumkum; Rajakumar, S; Puri, S K; Saxena, J K; Chauhan, P M S (2009)

Frequency of malaria and its resistance to chemotherapeutic options are emerging rapidly. To counter this problem, a series of 4–aminoquinolines having oxalamide and triazine functionalities in the side chain were synthesized ...
Novel Aryloxy azolyl chalcones with Potent Activity against Mycobacterium tuberculosis H37Rv

Marrapu, V K; Chaturvedi, Vinita; Singh, Shubhra; Singh, Shyam; Sinha, Sudhir; Bhandari, Kalpana (2011)

A series of twenty seven novel aryloxy azolyl chalcones were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Ten compounds from this series exhibited good activity with MIC ...
A QSAR study on 2-(4-Methylpiperazin-1-yl) quinoxalines as human histamine H4 receptor ligands

Sharma, B K; Pilania, Pradeep; Singh, P; Prabhakar, Y S (2011)

The histamine H4 receptor binding affinity of 2-(4-Methylpiperazin-1-yl)quinoxaline derivatives have been quantitatively analyzed in terms of Dragon descriptors. The derived QSAR models have provided rationales to explain ...
2D Gel Electrophoresis based Proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK mediated apoptosis in chronic myeloid leukemia cells K562

Pal, Pooja; Kanaujiya, J K; Lochab, Savita; Tripathi, S B; Bhatt, M L B; Singh, P K; Sanyal, Sabyasachi; Trivedi, A K (2011)

Ormeloxifen is a non-steroidal selective estrogen receptor modulator (SERM) and has been shown to possess anticancer activities in breast and uterine cancer. Here, we show that ormeloxifen induces apoptosis in dose dependent ...
Liquid chromatography–mass spectrometry method for the quantification of tamoxifen and its metabolite 4-hydroxytamoxifen in rat plasma: Application to interaction study with biochanin A (an isoflavone)

Singh, S P; Wahajuddin; Ali, M M; Kohli, Kanchan; Jain, G K (2011)

Tamoxifen is the agent of choice for the treatment of estrogen receptor-positive breast cancer. Tamoxifen is a substrate of P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A, and biochanin A (BCA) is an inhibitor ...
An efficient non-ionic surfactant catalysed multicomponent synthesis of novel Benzylamino coumarin derivative via Mannich type reaction in water

Kumar, A; Gupta, Manish K; Kumar, Mukesh (2011)

We have developed an efficient non-ionic surfactant catalysed multicomponent synthesis of novel Benzylamino coumarin derivatives from secondary amines, aromatic aldehyde and 4-hydroxy coumarin via Mannich type reaction in ...
A novel stereoselective one-pot synthesis of 2-susbstituted amino-5,6-dihydro-4H-1,3-thiazines via primary allylamines afforded from Morita-Baylis-Hillman acetates

Bhowmik, Subhendu; Mishra, Amita; Batra, Sanjay (2011)

A new stereoselective synthesis of 2-susbstituted amino-5,6-dihydro 4H-1,3-thiazines using primary allylamines obtained from the Morita-Baylis-Hillman (MBH) acetates is described. The primary allylamines react with aryl ...
Sufficiency of a single administration of filarial antigens adsorbed on polymeric lamellar substrate particles of poly (l-lactide) for immunization

Sainia, Vinay; Verma, S K; Sahoo, M K; Kohlia, D V; Murthy, P K (2011)

A majority of antigens require repeated administration to ensure development of adequate humoral and cell mediated immune response. To minimize the number of administrations required, we investigated the utility of ...

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