Metronidazole (MTZ), the FDA approved drug against Trichomonas vaginalis (TV), is being challenged seriously by drug resistance; while its inertness to sperm makes it ineffective as a vaginal contraceptive. Thirteen ...

Syntheses of a variety of aza-polycycles employing 2-(N-allylaminomethyl)cinnamaldehydes derived from Morita-Baylis-Hillman adducts of acrylates via intramolecular 1,3-dipolar cycloaddition, or Aza-Diels-Alder or domino ...

A simple, sensitive and specific reversed phase high performance liquid chromatographic (RP-HPLC) method for simultaneous determination of atenolol, paracetamol, hydrochlorothiazide, caffeine, cephalexin, metoprolol, ...

The aim of this study was to prepare natamycin encapsulated lecithin/chitosan mucoadhesive nanoparticle (NPs) for prolonged ocular application. These NPs were characterized by their mean particle size 213 nm, encapsulation ...

Breast cancer is the most common cancer diagnosed in women and the second most common cause of female cancer related deaths with more than one million new cases diagnosed per year throughout the world. With the recent ...

Hypaphorine, an α-N,N,N-trimethyltryptophan betaine, is isolated as major constituent from Impatiens niamniamensis seeds (Balsaminaceae) for the first time. The structure of the compound was established by spectroscopic ...

The present study was designed to evaluate the anti-ulcerogenic properties of an alkaloid chromane, rohitukine from Dysoxylum binecteriferum. Anti-ulcer potential of rohitukine was assessed in cold restrained, pyloric ...

Following a lead obtained from stem-bark extract of Butea monosperma, two structurally related methoxyisoflavones; cajanin and isoformononetin were studied for their effects in osteoblasts. Cajanin had strong mitogenic as ...

1, 4-disubstituted -1, 2, 3-triazoles (3-27) have been synthesized by [3+2] cycloaddition of different 2-(azidomethyl)- dihydronaptho (benzo)furans (2a, 2b, 2c and 2d) with different alkynes. All the compounds were screened ...

A new chemical access has been developed for the synthesis of 3′-acetyl-4′-hydroxychalcones from 1-(5-acetyl-2-hydroxy-phenyl)-ethanone and various substituted benzaldehydes via a regioselective Claisen-Schmidt condensation ...