Abstract:
We have developed an efficient non-ionic surfactant catalysed multicomponent synthesis of novel Benzylamino coumarin derivatives from secondary amines, aromatic aldehyde and 4-hydroxy coumarin via Mannich type reaction in water. In this Mannich type reaction, surfactant forms stable colloidal medium to stabilised iminium ion which undergoes nucleophilic addition of 4-hydroxy coumarin to give Benzylamino coumarin in very good yields.
