Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer†

Kumar, Shailesh; Deshpande, Shreekant; Kitchlu, Shakti; Chandra, Vishal; Dwivedi, Anila; Nayak, V L; Konwar, Rituraj; Prabhakar, Y S; Sahu, D P

Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer†

Kumar, Shailesh; Deshpande, Shreekant; Kitchlu, Shakti; Chandra, Vishal; Dwivedi, Anila; Nayak, V L; Konwar, Rituraj; Prabhakar, Y S; Sahu, D P

URI: http://hdl.handle.net/123456789/758

Date: 2009

Abstract:

A novel class of 2,3,4-triarylbenzopyrans has been synthesized and were evaluated for their selective estrogen receptor rmodulation and anti-proliferative activities. 10a and 11c exhibited 73.91 and 69.24 % inhibition as estrogen antagonistic activity respectively. 11a showed lowest MIC at 6.971µM against MCF-7 cell line and 10h showed lowest MIC at 6.971µM against MDA-MB-231 cell line

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