Studies in Metabolism, Absorption, Distribution & the Mode of Excretion of 4: 4'-Diaminodiphenyl Sulfide

Khosla, M C; Kohli, J D; Anand, Nitya

dc.contributor.author	Khosla, M C
dc.contributor.author	Kohli, J D
dc.contributor.author	Anand, Nitya
dc.date.accessioned	2012-10-22T11:13:32Z
dc.date.available	2012-10-22T11:13:32Z
dc.date.issued	1959
dc.identifier.citation	Journal of Scientific and Industrial Research 1959, 18C, 51-56	en
dc.identifier.uri	http://hdl.handle.net/123456789/961
dc.description.abstract	Conditions have been standardized for the estimation of 4 : 4' -diaminodiphenyl sulfide in the presence of biological materials and its metabolism has been studied. The drug is absorbed gradually over a long period and is distributed fairly uniformly in all the tissues, except the brain, and it does not seem to be able to cross the blood-brain barrier. The main route of excretion is the kidneys. The drug circulates in the blood mainly in the form of a polar conjugate of 4 : 4'diaminodiphenyl sulfide. The major metabolites in the rabbit and human urine were 4: 4' -diaminodiphenyl sulfide, the corresponding sulfoxide, sulfone and a polar unidentified compound. A method has been standardized for the salting out chromatography of 4: 4'diaminodiphenyl sulfide, sulfoxide and sulfone; and the method is particularly suitable for sulfides, since these give rather high and unpredictable Rf values by conventional paper partition chromatography.·	en
dc.format.extent	669577 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Diaminodiphenyl	en
dc.subject	Sulfide	en
dc.subject	Metabolism	en
dc.subject	Excretion	en
dc.title	Studies in Metabolism, Absorption, Distribution & the Mode of Excretion of 4: 4'-Diaminodiphenyl Sulfide	en
dc.type	Article	en