Synthesis and evaluation of antithrombotic activity of benzocoumarin amide derivatives

Sashidhara, K V; Palnati, G R; Avula, S R; Singh, S; Jain, Manish; Dikshit, Madhu

dc.contributor.author	Sashidhara, K V
dc.contributor.author	Palnati, G R
dc.contributor.author	Avula, S R
dc.contributor.author	Singh, S
dc.contributor.author	Jain, Manish
dc.contributor.author	Dikshit, Madhu
dc.date.accessioned	2012-09-11T11:06:01Z
dc.date.available	2012-09-11T11:06:01Z
dc.date.issued	2012
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters2012, 22 (9), 3115–3121	en
dc.identifier.uri	http://hdl.handle.net/123456789/916
dc.description.abstract	A series of novel benzocoumarin amide derivatives have been synthesized and evaluated for their antithrombotic activity in an established model of mouse thrombosis. Compound 8 showed 45% protection, whereas, standard drug aspirin provided 37% protection. Furthermore, compounds 5, 7, and 8 were significantly shown anti-platelets and anti-coagulant action. In that way suggesting its potential as novel antithrombotic agents.	en
dc.format.extent	215685 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 8219	en
dc.subject	Pechmann condensation	en
dc.subject	1,5dihydroxynaphthalene	en
dc.subject	Benzocoumarins amide	en
dc.subject	Antithrombotic activity	en
dc.subject	Bleeding time	en
dc.subject	Anti-platelet	en
dc.subject	Anti-coagulant	en
dc.title	Synthesis and evaluation of antithrombotic activity of benzocoumarin amide derivatives	en
dc.type	Article	en